Interaction between dopamine D1 and D2 receptors in modulation of the immune response.

Abstract:

:The interaction between dopamine D1 and D2 receptors plays a role in immunomodulation. The results of thus interaction depends on the degree of receptor activation with selective agonists in different doses. Combined treatment with agonists of D1 and D2 receptors in high doses had a synergistic effect in the mechanisms of immunomodulation. Receptor agonists in low doses suppressed the immune response. Our results suggest that weak activation of one of these receptors is accompanied by inactivation of the other receptor type.

journal_name

Bull Exp Biol Med

authors

Devoino LV,Al'perina EL,Gevorgyan MM,Cheido MA

doi

10.1007/s10517-006-0218-9

subject

Has Abstract

pub_date

2006-05-01 00:00:00

pages

553-5

issue

5

eissn

0007-4888

issn

1573-8221

journal_volume

141

pub_type

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