Abstract：
:Plasma γ-globulin fraction proteins, copper and zinc cations, and metal complexes formed by these cations and human serum γ-globulin induce blast transformation of splenocytes from BALB/c mice at a level comparable to that induced by concanavalin A. Zinc bound to γ-globulin reduces by 25% and copper in complex with this protein stimulates by 1.6 times its capacity to induce blast transformation. Combinations with concanavalin A reproduce the effects of γ-globulin-metal complex under conditions of mitogen induction. Incorporation of(3)H-thymidine in splenocytes incubated with combinations of γ-globulin-copper metalcomplex, copper cations, and control protein with concanavalin A was by 1.4, 1.3 (p<0.1), and 1.25 times higher (p<0.05), respectively, than after incubation with concanavalin A alone.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Cheknev SB,Grigorjeva EA,Nikolaeva TN,Pronin AVdoi
10.1007/s10517-011-1206-2subject
Has Abstractpub_date
2011-03-01 00:00:00pages
624-6issue
5eissn
0007-4888issn
1573-8221journal_volume
150pub_type
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