Metabolic activity of cells in brain cortex after alcohol intoxication and correction of changes with Dolivin.

Abstract:

:Metabolic processes in the brain cortex of albino rats with prenatal and postnatal alcohol intoxication were studied by the method of electron paramagnetic resonance. Accumulation of superoxide radical-generating agents, inactivation of superoxide dismutase, and increase in nitric oxide concentration were detected. Activation of free radical processes was associated with accumulation of Mn(2+)and Fe(2+). The parameters of electron paramagnetic resonance returned to normal after Dolivin treatment. These changes were accompanied by a decrease in the intensity of oxidative metabolism.

journal_name

Bull Exp Biol Med

authors

Museridze DP,Sanikidze TV,Svanidze IK

doi

10.1007/s10517-006-0347-1

subject

Has Abstract

pub_date

2006-09-01 00:00:00

pages

283-5

issue

3

eissn

0007-4888

issn

1573-8221

pii

doi

journal_volume

142

pub_type

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