Abstract：
:The glucocorticoid status and activities of ALT, AST, and tyrosine aminotransferase in the liver are studied in rats with streptozotocin-induced diabetes mellitus in response to repeated intraperitoneal injections of mifepristone. Diabetic rats develop an increase of the blood corticosterone and liver aminotransferase levels in response to mifepristone. These results indicate that in diabetic animals the glucocorticoid hormones with high blood concentrations, increasing still more in response to mifepristone, overcome the receptor blockade, and realize their regulatory functions in hepatocytes. The effects of mifepristone on ALT activity are the most manifest. In normal rats, only ALT activity is increasing in response to mifepristone, while in rats with streptozotocin-induced diabetes mellitus, ALT activity increases more intensely than activities of tyrosine aminotransferase and AST.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Pal'chikova NA,Selyatitskaya VG,Kuz'minova OI,Pasechnaya KVdoi
10.1007/s10517-018-4197-4subject
Has Abstractpub_date
2018-08-01 00:00:00pages
474-477issue
4eissn
0007-4888issn
1573-8221pii
10.1007/s10517-018-4197-4journal_volume
165pub_type
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