Role of variations in pulmonary and cardiac hemodynamics in the reduction of the venous return during experimental ischemia of the left ventricular myocardium.

abstract：:We studied the effects of lithium carbonate on the cell cycle, apoptosis, and autophagy in hepatocellular carcinoma-29 cells (HCC-29) in vitro. Flow cytofluorometry analysis revealed accumulation of G2/M-phase HCC-29 cells and increase in the number of apoptotic cells in 48 h after administration of 5 mM lithium carbo...

journal_title：Bulletin of experimental biology and medicine

authors： Taskaeva YS,Bgatova NP,Dossymbekova RS,Solovieva AO,Miroshnichenko SM,Sharipov KO,Tungushbaeva ZB

更新日期：2020-12-01 00:00:00

abstract：:Administration of granulocyte CSF preparation to patients with chronic heart failure produced a hemostimulating effect and increased the content of leukocytes and neutrophils in the peripheral blood. Granulocyte CSF induced mobilization of bone marrow progenitor cells into the peripheral blood. The content of hemopoie...

journal_title：Bulletin of experimental biology and medicine

authors： Konenkov VI,Pokushalov EA,Poveshchenko OV,Kim II,Romanov AB,Guleva NA,Bernvald VV,Soloviova AO,Yankayte EV,Poveshchenko AF,Karaskov AM

更新日期：2012-05-01 00:00:00

abstract：:We studied the expression of genes encoding angiotensinogen (Agt), renin (Ren), angiotensin-converting enzyme (ACE), and type 1 angiotensin receptor (AT1A) in the hypothalamus and medulla oblongata of hypertensive ISIAH rats and normotensive WAG rats. The amount of Agt mRNA in the hypothalamus of young ISIAH rats was ...

journal_title：Bulletin of experimental biology and medicine

authors： Klimov LO,Fedoseeva LA,Ryazanova MA,Dymshits GM,Markel AL

更新日期：2013-01-01 00:00:00

abstract：:The degree of oxygen consumption in rats was determined after intraperitoneal injection of morphine in a single dose of 5 mg/kg. Some animals were injected with morphine and perorally received morphine or antibodies to mu-opiate receptors in ultralow doses obtained by the technology of potentiation. Potentiated substa...

journal_title：Bulletin of experimental biology and medicine

authors： Pavlov IF,Epstein OI

更新日期：2003-01-01 00:00:00

abstract：:Morphological and proliferative characteristics of cultured Vero and MDCK cells were compared after growth in nutrient media of the basis of enzymatic hydrolysates of rice flour proteins and soybean flour proteins or control media (DMEM and Axcevir-MDCK). These media had a strong stimulatory effect on the growth of cu...

journal_title：Bulletin of experimental biology and medicine

authors： Mazurkova NA,Ryabchikova EI,Troshkova GP,Getmanova TN,Sumkina TP,Shishkina LN,Sergeev AN

更新日期：2009-04-01 00:00:00

abstract：:Here we present the results of histochemical detection of 3β-hydroxysteroid dehydrogenase in neurons of the neocortex, cerebellum, and brainstem. The positive reaction was observed in a low number of neocortical, midbrain, and pontine neurons. The maximum number of positive neurons was detected in the cerebellar corte...

journal_title：Bulletin of experimental biology and medicine

authors： Ryzhavskii BY,Litvintseva VM

更新日期：2012-01-01 00:00:00

abstract：:Peroral administration of alpha-tocopherol in a daily dose of 150 mg/kg for 1, 4, 8, and 12 days leads to induction of cytochromes P450 1A in male rats. Activity of CYP1A1 and CYP1A2 increased most significantly one day after alpha-tocopherol administration (by 2.6 and 2.7 times, respectively). CYP1A1 was immunohistoc...

journal_title：Bulletin of experimental biology and medicine

authors： Sidorova YA,Grishanova AY,Lyakhovich VV

更新日期：2004-09-01 00:00:00

abstract：:C57Bl/6 mice were intranasally infected with influenza virus A/H5N1 A/goose/Krasnoozerskoye/627/05. The mortality rate of animals reached 70% on day 14 of the disease. The lungs of animals were characterized by necroses, destruction of vessels, hemorrhagic and thrombotic complications, edematous syndrome, and early fi...

journal_title：Bulletin of experimental biology and medicine

authors： Kovner AV,Anikina AG,Potapova OV,Sharkova TV,Cherdanceva LA,Shkurupy VA,Shestopalov AM

更新日期：2012-06-01 00:00:00

abstract：:Studies of the molecular mechanisms of esophageal cancer development have to be carried out on sufficient amount of tumor material, obtained under conditions of controlled exposure to carcinogenic factors. Esophageal cancer models on laboratory animals serve an indispensable source of this material. One of these model...

journal_title：Bulletin of experimental biology and medicine

authors： Shubin AV,Lesovaya EA,Kirsanov KI,Antoshina EE,Trukhanova LS,Gorkova TG,Belitsky GA,Yakubovskaya MG,Demidyuk IV

更新日期：2018-03-01 00:00:00

abstract：:The possibility of using hyaluronidase for the regulation of the state of different pools of mesenchymal precursors in vivo was demonstrated. The reaction of mesenchymal precursor cells depended on the dose of the enzyme. Administration of hyaluronidase in a dose of 20 U/mouse increased the content of stromal precurso...

journal_title：Bulletin of experimental biology and medicine

authors： Goldberg ED,Dygai AM,Zyuz'kov GN,Zhdanov VV,Simanina EV,Gur'yantseva LA

更新日期：2007-04-01 00:00:00

abstract：:We studied the effects of dipeptidyl peptidase 4 (DPP4) inhibitor linagliptin on the expression of apoptosis regulator proteins Bcl-2 and Bad in the liver of db/db mice with genetically determined obesity and type 2 diabetes mellitus. The mice received daily linagliptin or saline (placebo) by gavage from week 10 to we...

journal_title：Bulletin of experimental biology and medicine

authors： Michurina SV,Cherepanova MA,Ishchenko IY,Arkhipov SA,Klimontov VV,Zav'yalov EL

更新日期：2019-06-01 00:00:00

abstract：:The anti-ischemic effect of synthetic and pharmacologically tested anxiolytic afobazole (10 mg/kg intravenously) was studied on anesthetized rats with acute endocardial ischemia caused by isoproterenol infusion (20 mg/kg/min). A calcium antagonist verapamil (1 mg/kg intravenously) belonging to the group of phenyl alky...

journal_title：Bulletin of experimental biology and medicine

authors： Seredenin SB,Tsorin IB,Vititnova MB,Stolyaruk VN,Chichkanov GG,Kryzhanovskii SA

更新日期：2013-10-01 00:00:00

abstract：:The rats were divided into groups demonstrating extremely high and low stress reactivity depending on the results of testing for the nociceptive threshold and thermolability in response to bacterial lipopolysaccharide administration. Specific structural features of the nucleus and mitochondria were revealed in neurons...

journal_title：Bulletin of experimental biology and medicine

authors： Potanin MB,Tumanov VP,Pisarev VB

更新日期：2007-11-01 00:00:00

abstract：:The levels of himantane and its metabolites in daily urine and feces of rats were measured after intraperitoneal and oral dose of 25 mg/kg. The injected dose of the initial substance and 1.3% its metabolites were eliminated with excrements within 24 h after administration via both routes 0.23%. ...

journal_title：Bulletin of experimental biology and medicine

authors： Litvin EA,Bastrygin DV,Kolyvanov GB,Alekseyev KV,Zherdev VP

更新日期：2012-08-01 00:00:00

abstract：:The appearance of autoantibodies to neuronal proteins (S100, GFAP, MBP, and NGF) in rat serum was analyzed by ELISA on days 5, 10, 17, 25, and 32 after streptozotocin injection. Simultaneously, blood glucose and insulin autoantibodies were assayed. Serum glucose level increased on the next day after streptozotocin inj...

journal_title：Bulletin of experimental biology and medicine

authors： Lotosh NG,Savel'eva EK,Selishcheva AA,Savel'ev SV

更新日期：2013-05-01 00:00:00

abstract：:The time course of drug adsorption and desorption, exposure of soft contact lenses in a drug solution needed for maximum saturation, and the duration of lens wearing during which the drug was transported from the lens and exhibited its therapeutic activity were studied. The possibility of using computer simulation for...

journal_title：Bulletin of experimental biology and medicine

authors： Zhilyakova ET,Novikov OO,Akopova VV

更新日期：2013-12-01 00:00:00

abstract：:Intraperitoneal injection of Semax (synthetic analogue of ACTH4-7, MEHFPGP) in a dose of 50 mg/kg produced a protective effect on rats with experimental indomethacin-induced ulcers. Experiments on narcotized rats showed that Semax in the studied dose had no effect on basal blood flow in the stomach, but prevented redu...

journal_title：Bulletin of experimental biology and medicine

authors： Zhuikova SE,Sergeev VI,Samonina GE,Myasoedov NF

更新日期：2002-06-01 00:00:00

abstract：:Intensive exercise triggers the cascade processes of body adaptation, including modulation of splisosome functioning, and can lead to modification of its activity and choice of alternative exons. We studied the effect of exercise of the maximum aerobic power on activation of transcription of genes involved in the spli...

journal_title：Bulletin of experimental biology and medicine

authors： Tonevitsky EA,Trushkin EV,Shkurnikov MU,Akimov EB,Sakharov DA

更新日期：2009-06-01 00:00:00

abstract：:We propose a noninvasive method of in vivo examination the hemostasis system based on speckle pattern analysis of coherent light scattering from the skin. We compared the results of measuring basic blood coagulation parameters by conventional invasive and noninvasive methods. A strict correlation was found between the...

journal_title：Bulletin of experimental biology and medicine

authors： Kuznik BI,Fine IW,Kaminsky AV

更新日期：2011-09-01 00:00:00

abstract：:We studied the role of insulin-like growth factors 1 and 2 (IGF-1 and IGF-2) in functional differentiation of HC11 mouse mammary gland cells. It was found that both IGF-1 and IGF-2 activate the expression of milk protein β-casein in the presence of prolactin and hydrocortisone. It was found that β-casein expression is...

journal_title：Bulletin of experimental biology and medicine

authors： Shushanov SS

更新日期：2011-12-01 00:00:00

abstract：:Hemopoietic islets, associations of stromal (macrophages, fibroblasts) and blood (including stem) cells, are structural and functional units of the bone marrow. We studied cellular and molecular processes developing following short-term (1 h) contact of hemopoietic islets with ferromagnetic nanoparticles in a multicel...

journal_title：Bulletin of experimental biology and medicine

authors： Novitsky VA,Khlusov IA,Ryazantseva NV,Chechina OE,Feduschak TA,Ermakov AE,Uimin MA

更新日期：2011-08-01 00:00:00

abstract：:Comparative analysis of the efficiency of PCR and microbiological methods for deciphering of the etiological structure of non-nosocomial pneumonias demonstrated the diagnostic significance of detecting Streptococcus pneumoniae DNA in the blood, but not sputum. Mechanisms of penetration of S. pneumoniae into the blood ...

journal_title：Bulletin of experimental biology and medicine

authors： Artemova LV,Beskhlebnaya VA,Ezhova LG,Kirillov MY,Kravtsov EG,Dalin MV

更新日期：2003-10-01 00:00:00

abstract：:The distribution of pacemaker cells and atrial working cardiomyocytes in the anterior right atrial wall was studied using intracellular glass microelectrodes under conditions of short-term culturing. It was shown that the dominant pacemaker region and the functional tail are located in the lateral area of the central ...

journal_title：Bulletin of experimental biology and medicine

authors： Sutyagin PV,Kamkin AG,Gurina OY

更新日期：2009-09-01 00:00:00

abstract：:We studied the effect of glyprolines Pro-Gly-Pro (PGP) and Arg-Gly-Pro (RGP) on the primary culture of pulmonary fibroblasts from newborn albino rats under normal conditions and during oxidative stress. Under physiological conditions, the peptides had no effect on parameters of cell division. Hydrogen peroxide induced...

journal_title：Bulletin of experimental biology and medicine

authors： Tolstenok IV,Fleishman MY,Sazonova EN,Lebed'ko OA,Maltseva IM,Myasoedov NF,Timoshin SS

更新日期：2016-05-01 00:00:00

abstract：:Age-associated changes in the concentrations of glucose, insulin, and DHEAS in peripheral blood plasma of female rhesus macaques were studied in intact animals and in response to a standard dose of glucose and insulin. Basal levels of insulin and glucose increased, insulin sensitivity and glucose tolerance decreased, ...

journal_title：Bulletin of experimental biology and medicine

authors： Goncharova ND,Vengerin AA,Oganyan TE,Lapin BA

更新日期：2004-03-01 00:00:00

abstract：:Oxygen-dependent processes in peripheral blood monocytes were intensified in patients with metabolic cardiovascular syndrome. This was manifested in increased production of O(2)(*-) and NO. Among metabolic factors (cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triacylglycerols...

journal_title：Bulletin of experimental biology and medicine

authors： Suslova TE,Gruzdeva OV,Fedorova TS,Karpov RS

更新日期：2004-05-01 00:00:00

abstract：:Exposure of rats with experimental diabetes mellitus to wide-band electromagnetic radiation generated by He-Ne laser and modulated by the pancreas and spleen is informing and phenomenological method prolonging animal life span, normalizing blood glucose level, and promoting regeneration of the pancreas. ...

journal_title：Bulletin of experimental biology and medicine

authors： Garyaev PP,Kokaya AA,Mukhina IV,Leonova-Garyaeva EA,Kokaya NG

更新日期：2007-02-01 00:00:00

abstract：:We compared cytotoxic activity of blood mononuclear leukocytes from healthy donors and lymphokine-activated killer cells generated from them towards tumor and normal cells. Lymphokine-activated killer cells exhibited higher (in comparison with blood mononuclear leukocytes) killer activity towards tumor cells. Lymphoki...

journal_title：Bulletin of experimental biology and medicine

authors： Zhukova OS,Lebedinskaya OV,Shubina IZh,Gerasimova GK,Karamzin AM,Kiselevskii MV

更新日期：2007-01-01 00:00:00

abstract：:Alofanib is a potential allosteric inhibitor of FGFR2 used in oncology. The inhibitor blocks the extracellular part of the receptor and prevents its binding with the ligand. Alofanib suppressed proliferation of endothelial cells, their migration activity, and ability to form vessellike structures in vitro and signific...

journal_title：Bulletin of experimental biology and medicine

authors： Khochenkov DA,Solomko ES,Peretolchina NM,Ryabaya OO,Stepanova EV

更新日期：2015-11-01 00:00:00

abstract：:Typical signs of cardiomyoblasts were determined: high mitochondrial membrane potential and high number of mitochondria in these cells compared to fibroblasts. These signs can be used for identification of these cells. Energy-dependent accumulation of highly specific mitochondrial fluorescent probes applied for visual...

journal_title：Bulletin of experimental biology and medicine

authors： Khryapenkova TG,Plotnikov EY,Korotetskaya MV,Sukhikh GT,Zorov DB

更新日期：2008-10-01 00:00:00