Abstract：
:The appearance of autoantibodies to neuronal proteins (S100, GFAP, MBP, and NGF) in rat serum was analyzed by ELISA on days 5, 10, 17, 25, and 32 after streptozotocin injection. Simultaneously, blood glucose and insulin autoantibodies were assayed. Serum glucose level increased on the next day after streptozotocin injection and the level of autoantibodies to insulin significantly increased on day 5 indicating the development of diabetes. The levels of antibodies to specific neuronal proteins (S100, GFAP, MBP, and NGF) also increased at this term. It is concluded that diabetes with streptozotocin is associated with damage to the blood-brain barrier.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Lotosh NG,Savel'eva EK,Selishcheva AA,Savel'ev SVdoi
10.1007/s10517-013-2077-5subject
Has Abstractpub_date
2013-05-01 00:00:00pages
48-51issue
1eissn
0007-4888issn
1573-8221journal_volume
155pub_type
杂志文章abstract：:We studied the effect of 20 standard L-amino acids on proliferation of the nervous, cardiovascular, urogenital, digestive, and immune system tissues from young and old animals in organotypic cultures. The effect of amino acids on tissue culture proliferation depended on their origin and animal age. ...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-013-2200-7
更新日期：2013-08-01 00:00:00
abstract：:Cytogenetic analysis of 13 mesenchymal stem cell cultures isolated from normal human adipose tissue was carried out at different stages of culturing. The incidence of chromosomes 6, 8, 11, and X aneuploidy and polyploidy was studied by fluorescent in situ hybridization. During the early passages, monosomal cells were ...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-009-0647-3
更新日期：2009-07-01 00:00:00
abstract：:We studied the effect of interleukin-1beta on the behavior of rats with different individual typological characteristics during mild stress in the open-field test. Intraperitoneal injection of interleukin-1beta (5 microg/kg, 108 U/mg) was followed by a decrease in orientation and exploratory activity of passive and, p...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-010-0804-8
更新日期：2009-11-01 00:00:00
abstract：:Structural characteristics of the adrenal medulla in hypertensive NISAG rats (hereditary stress-induced arterial hypertension) were studied during various periods of postnatal ontogeny. Signs of hyperplasia of the adrenal medulla were most pronounced in adult hypertensive animals with persistent arterial hypertension,...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-006-0441-4
更新日期：2006-12-01 00:00:00
abstract：:We studied the mechanisms of erythropoiesis stimulation and effectiveness of Poetam, a preparation containing release-active anti-erythropoietin antibodies as a supplement treatment for experimental iron deficiency anemia during gestation. The results confirmed potency of combined therapy to stimulate erythropoiesis, ...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-016-3298-1
更新日期：2016-04-01 00:00:00
abstract：:We studied changes in the blood cytokine profile of rats 3 h, 1 day, and 8 days after acute stress on the model of 24-h immobilization followed by LPS administration (100 μg/kg intraperitoneally). The concentration of proinflammatory cytokines (particularly of IL-1β and TNFα) significantly decreased at the early stage...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-020-04786-w
更新日期：2020-04-01 00:00:00
abstract：:We studied reflection of artificially induced and amplified food motivation in impulse activity of the masticatory muscles during electrostimulation of "hunger center" of the lateral hypothalamus in the absence and presence of food. The threshold stimulation of the lateral hypothalamus in hungry and satiated animals i...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-012-1602-2
更新日期：2012-04-01 00:00:00
abstract：:The mechanism of interaction of hypochlorite and hypobromite formed in myeloperoxidase catalysis with lipids of human blood low-density lipoprotein is described. Both agents react with unsaturated lipids via two mechanisms: molecular (with the formation of mainly chloro- or bromohydrins and lysophospholipids) and free...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-007-0346-x
更新日期：2007-09-01 00:00:00
abstract：:Antioxidant properties of recombinant peroxiredoxin-6 and chimeric protein PSH combining peroxidase and superoxide dismutase activities were studied on the model of retrograde perfusion of isolated rat heart under conditions of H2O2-induced oxidative stress. The exogenous antioxidant proteins exhibited cardioprotectiv...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-016-3237-1
更新日期：2016-03-01 00:00:00
abstract：:We studied the rate of development of tolerance to the ethanol-induced analgesia under the effect of μ-, δ-, and κ-opioid agonists and antagonists not crossing the blood-brain barrier and rapidly inactivated by gastric and duodenal proteolytic enzymes. Activation of gastric κ-opioid receptors eliminated the analgesic ...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-017-3760-8
更新日期：2017-06-01 00:00:00
abstract：:We studied a biomaterial for a new domestic product, a biological envelope for implantation of cardiac electronic devices. The product is designed to prevent complications after pacemaker implantation and to facilitate the reimplantation procedure. By chemical and biological processing of raw materials (submucosa of p...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-020-04712-0
更新日期：2020-01-01 00:00:00
abstract：:The micronucleus test was used tu study the possibility of inducing cross-adaptive response in mouse bone marrow cells in vivo with an 850 nm infrared light modulated by a 101 Hz frequency, emitted by a light therapy device "Kurator". We demonstrated that this exposure led to a substantial reduction of cytogenetic cel...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-009-0522-2
更新日期：2009-04-01 00:00:00
abstract：:Differential expression of type 1 cannabinoid receptors (CR1) was evaluated at different stages of human skin fibroblast transformation into terminally differentiated neurons. Immunocytochemical staining detected no CR1 on fibroblasts, but their transformation into induced pluripotent stem cells was accompanied by mar...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-017-3782-2
更新日期：2017-06-01 00:00:00
abstract：:Data are presented on chemical study of flavonoid glycosides in some botanical subjects using matrix-assisted laser desorption ionization, compared to HPLC. The method of matrix-assisted laser desorption ionization (MALDI) allows characterizing the composition of anthocyanin and flavonoid mixture without preliminary s...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-013-1960-4
更新日期：2013-01-01 00:00:00
abstract：:During exacerbation of cytomegalovirus infection during pregnancy, cytomegalovirus proteins penetrate across the external membrane of placental villous syncytiotrophoblast and suppress activities of ATPase and Bcl-2 protein. Simultaneous increase in the content of annexin V and caspase 3 leads to structural disturbanc...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-016-3162-3
更新日期：2016-01-01 00:00:00
abstract：:We studied transcriptional activity in the higher avian center visual system (Wulst area) in acoustically guided defensive behavior in visually deprived and non-deprived nestlings to evaluate the effects of visual afferentation on functional involvement of visual structures in acoustically guided defensive behavior. E...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-012-1781-x
更新日期：2012-09-01 00:00:00
abstract：:Arginine-vasopressin or arginine-vasotocin hormones introduced into the small intestine are absorbed and exert a hydrosmotic effect. The amount of absorbed antidiuretic hormone increased when it is introduced with intestinal peptidase inhibitor aprotinin. These data attest to the possibility of absorption of pituitary...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1023/b:bebm.0000024370.53746.ac
更新日期：2004-01-01 00:00:00
abstract：:Medical histories of 101 urothelial bladder cancer patients were compared with the results of morphological analysis and biomolecular detection of human papilloma viruses (HPV) in the tumor specimens. DNA of HPV16 (the major type of virus responsible for appearance of cervical carcinoma) was detected in 38 specimens, ...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-016-3354-x
更新日期：2016-05-01 00:00:00
abstract：:We studied the effect of extracellular purine nucleotides (NAD+ and ATP) on spontaneous arrhythmogenic activity caused by norepinephrine in myocardial sleeves of pulmonary veins. In pulmonary veins, NAD+ and ATP reduced the frequency of action potentials and their duration at regular type of spontaneous activity cause...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-017-3664-7
更新日期：2017-03-01 00:00:00
abstract：:We studied the influence of the characteristics of oxide porous coatings on osteogenesis and integration of new bone tissue and titanium implant surface in the ectopic osteogenesis test. Implants with coating with pore size 2-20 μ exhibit better osteogenic and osteoconductive characteristics than implants with homogen...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-017-3719-9
更新日期：2017-04-01 00:00:00
abstract：:We studied the effects of individual or combination treatment with monoclonal antibodies 5F5-B6 in ultralow doses specifically marking mossy fibers in rat hippocampus and antibodies to S100 protein during long-term post-tetanic potentiation in hippocampal slices. The possible mechanisms of changes produced by therapeu...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1023/a:1024715821327
更新日期：2003-01-01 00:00:00
abstract：:The dependence of daily vitamin excretion with breast milk on dietary vitamin content and blood vitamin level was studied in nursing women. Breast mils vitamins were assayed in women supplied with vitamins. We identified the criteria for adequate vitamin supply in nursing women over the 1st month after labor (vitamins...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-006-0161-9
更新日期：2006-03-01 00:00:00
abstract：:The morphology of neural and glial cells in different cerebral areas and in various experimental models was quantitatively studied by methods of computer morphometry combined with video image analysis systems. The following parameters were obtained: density of neurons and glial cells per 1 mm(2), number of satellite p...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-010-0886-3
更新日期：2010-07-01 00:00:00
abstract：:We studied the involvement of protein kinase Mζ (PKMζ) in the mechanisms of amnesia development within 10 days after disruption of conditioned food aversion memory with ZIP (a PKMζ inhibitor). Repeated training performed in 3 days after amnesia induction with ZIP, led to the formation of conditioned food aversion memo...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-019-04605-x
更新日期：2019-10-01 00:00:00
abstract：:Fragments of the dorsolateral wall of the anterior brain vesicle from rat embryos on embryonic day 15 were dissociated and the resultant suspension containing single cells and cell aggregates was injected into the proximal segment of crushed sciatic nerve of adult animals for evaluation of their engrafting and differe...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-013-2296-9
更新日期：2013-11-01 00:00:00
abstract：:Preparations of I(125)-labeled monoclonal antibodies against neurospecific enolase and mouse plasma IgG1 were injected intravenously to rats immediately after unilateral occlusion of the middle cerebral artery. Radioactivity of I(125)-labeled monoclonal antibodies against neurospecific enolase in the brain tissue prog...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-005-0037-4
更新日期：2004-10-01 00:00:00
abstract：:We studied the effect of adrenal cortex hormone dehydroepiandrosterone sulfate on maturation and functional activity of interferon-alpha-induced dendritic cells. Dehydroepiandrosterone sulfate stimulated differentiation and maturation of interferon-alpha-induced dendritic cell, which manifested in a decrease in the nu...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-009-0619-7
更新日期：2009-07-01 00:00:00
abstract：:Intraleukocytic microbicidal activity of blood neutrophilic granulocytes in cows increased with increasing the term of pregnancy, decreased over the first 2 days after labor, and increased again in the follow-up period. Activity of microbicidal systems markedly decreased after labor, especially in the winter-spring pe...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1023/b:bebm.0000008968.87917.46
更新日期：2003-09-01 00:00:00
abstract：:Anticonvulsant activity and pharmacokinetics of nanoemulsion and unmodified substance of carbamazepine were compared in experiments on mice. Carbamazepine nanoemulsion demonstrated significant anticonvulsant activity and was superior to unmodified substance of carbamazepine against seizures induced by maximum electric...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-014-2657-z
更新日期：2014-10-01 00:00:00
abstract：:Cardiac and plasma activities of marker lysosomal enzymes were studied in Wistar rats with metabolic (epinephrine) and occlusion (ligation of coronary arteries) myocardial infarction. Activity of all examined lysosomal enzymes significantly increased in the myocardium and blood plasma starting from the first day after...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/BF02434867
更新日期：2000-06-01 00:00:00
