Role of myeloperoxidase-mediated modification of human blood lipoproteins in atherosclerosis development.

abstract：:We studied the formation and cytophysiological characteristics of polynuclear macrophages in primary cultures of peritoneal cells from C57Bl/6 mice. Production of reactive oxygen species and phagocytic activity in polynuclear macrophages were higher than in mononuclear macrophages. The formation of polynuclear macroph...

journal_title：Bulletin of experimental biology and medicine

authors： Arkhipov SA,Shkurupiy VA,Ijine DA,Ignatovich NV,Akhromenko ES,Arkhipova VV

更新日期：2008-12-01 00:00:00

abstract：:We studied the influence of high-fat diet on the development of metabolic syndrome in rats of hypertensive ISIAH strain and normotensive WAG strain. In contrast to ISIAH rats, high-fat diet in WAG rats led visceral obesity, glucose tolerance, and dyslipidemia. DNA-binding activity of the peroxisome proliferator-activa...

journal_title：Bulletin of experimental biology and medicine

authors： Dushkin MI,Khrapova MV,Kovshik GG,Chasovskikh MI,Selyatitskaya VG,Palchikova NA

更新日期：2014-03-01 00:00:00

abstract：:Lipophilic inhibitors of angiotensin-converting enzyme increased 6-month survival and/or lifetime of rats with experimental chronic heart failure. These drugs had no effect on the mortality rate of animals with acute decompensation of the disease. beta-Adrenoceptor blockers without intrinsic sympathomimetic activity n...

journal_title：Bulletin of experimental biology and medicine

authors： Fedorov VN,Sal'nikov EV,Sidorov AV,Bogatushin AV,Fateev MM

更新日期：2006-01-01 00:00:00

abstract：:We performed a comparative study of the cytotoxicity of cisplatin, JM216 complex, and aminonitroxyl platinum(IV) complexes for HeLa cells grown in monolayer and 3D culture. The growth dynamics of spheroids was studied and optimal conditions for evaluation of cytotoxicity were determined. Spheroids were less sensitive ...

journal_title：Bulletin of experimental biology and medicine

authors： Trigub ММ,Filatova NV,Areshidze DА,Sen' VD,Terentiev АА

更新日期：2020-02-01 00:00:00

abstract：:The content of low-molecular-weight components in blood serum was studied by tandem mass-spectrometry in pregnant women. Serum metabolic profiles of patients with a grave obstetrical history were detected. The most significant changes were observed for the concentrations of low-molecular-weight substances involved in ...

journal_title：Bulletin of experimental biology and medicine

authors： Khaustova SA,Senyavina NV,Tonevitsky AG,Eremina OV,Pavlovich SV

更新日期：2013-11-01 00:00:00

abstract：:We studied the structure of rhythms of BP, HR (by telemetric monitoring), electrolyte excretion (by capillary electrophoresis), and products of epiphyseal melatonin (by the urinary concentration of 6-sulfatoxymelatonin measured by ELISA) in normotensive Wistar-Kyoto rats and spontaneously hypertensive SHR rats maintai...

journal_title：Bulletin of experimental biology and medicine

authors： Blagonravov ML,Bryk AA,Medvedeva EV,Goryachev VA,Chibisov SM,Kurlaeva AO,Agafonov ED

更新日期：2019-11-01 00:00:00

abstract：:cDNA encoding VEGF and Ig-like extracellular domains 2-4 of VEGFR-1 (sFlt-1(2-4)) were cloned into prokaryotic expression vectors pET32a and pQE60. Recombinant proteins were purified (metal affinity chromatography) and renatured. Chemiluminescent study for the interaction of recombinant VEGF and sFlt-1(2-4) showed tha...

journal_title：Bulletin of experimental biology and medicine

authors： Leopol'd AV,Baklaushev VP,Korchagina AA,Shein SA,Grinenko NF,Pavlov KA,Ryabukhin IA,Chekhonin VP

更新日期：2012-04-01 00:00:00

abstract：:The influence of a new 2-mercaptobenzimidazole derivative afobazole on cytogenetic effects of dioxidine and cyclophosphamide was studied by counting chromosome aberrations in bone marrow cells of C57Bl/6 mice. Afobazole (1-100 mg/kg perorally) exhibited antimutagenic activity determined by its antioxidant properties. ...

journal_title：Bulletin of experimental biology and medicine

authors： Zhanataev AK,Durnev AD,Seredin SB

更新日期：2000-11-01 00:00:00

abstract：:The study examined maturation of preovulatory germinal vesicles oocytes (GV oocytes) induced by gonadotropic hormone PMSG in the inbred C57Bl/6J mice (viewed as a gold standard for diverse biomedical studies) as well as in the first generation hybrid C57Bl/6J×СВА/lac and СВА/lac×C57Bl/6J mice at various ages. The most...

journal_title：Bulletin of experimental biology and medicine

authors： Riabukha YA,Petrova DA,Zatsepina OV

更新日期：2019-09-01 00:00:00

abstract：:We demonstrated specific changes in platelet structure in different types of tuberculous process, in particular, shift in the proportion between alpha-granules, dense granules, different disorders in the mitochondrial and lysosomal apparatus, etc. The role of platelets in immune process is studied. Redistribution of a...

journal_title：Bulletin of experimental biology and medicine

authors： Khechinashvili GN,Khvitiya NG

更新日期：2004-11-01 00:00:00

abstract：:Location of cathepsin D and elastase in rat uterus was studied by electron-histochemical method. Activities of both proteinases in the myometrium was detected in lysosomes of smooth-muscle cells, macrophages, and fibroblasts. ...

journal_title：Bulletin of experimental biology and medicine

authors： Ryvnyak VV,Gudumak VS,Dulgieru OF

更新日期：2003-08-01 00:00:00

abstract：:The concentrations of proinflammatory cytokines (IL-1beta, IL-6), vascular endothelium growth factor, tumor growth factor-beta, and insulin-like growth factor-1 were measured in the peritoneal fluid of patients with external genital endometriosis and healthy women by enzyme immunoassay. The effect of peritoneal fluid ...

journal_title：Bulletin of experimental biology and medicine

authors： Sokolov DI,Solodovnikova NG,Pavlov OV,Niauri DA,Volkov NN,Sel'kov SA

更新日期：2005-11-01 00:00:00

abstract：:More than 70% malignant mammary tumors contain steroid hormone receptors; this suggests the possibility of hormone therapy in the majority of patients with breast cancer (BC). The main cause of inefficiency of hormone therapy in BC is hormone resistance (tumor resistance to hormonal cytostatics). Here we discuss the m...

journal_title：Bulletin of experimental biology and medicine

authors： Scherbakov AM,Krasil'nikov MA,Kushlinskii NE

更新日期：2013-07-01 00:00:00

abstract：:Trekrezan in a dose of 25 mg/kg normalized the lymphocyte immune status and produced an energy-stabilizing effect, which manifested in decreased levels of lactate, ADP, and AMP and increased content of pyruvate and ATP in blood lymphocytes and lung tissue of rats with experimental acute bronchopneumonia. ...

journal_title：Bulletin of experimental biology and medicine

authors： Zarubina IV,Bolekhan AV,Shabanov PD

更新日期：2006-08-01 00:00:00

abstract：:We developed a cytochrome P450 substrate-inhibitor panel for preclinical in vitro evaluation of drugs in a 3D histotypical microfluidic cell model of human liver (liver-on-a-chip technology). The concentrations of substrates and inhibitors were optimized to ensure reliable detection of the principal metabolites by HPL...

journal_title：Bulletin of experimental biology and medicine

authors： Zakhariants AA,Burmistrova OA,Shkurnikov MY,Poloznikov AA,Sakharov DA

更新日期：2016-11-01 00:00:00

abstract：:We performed a complex morphological analysis of atherosclerotic plaques obtained from 68 men with coronary atherosclerosis during coronary bypass surgery with endarterectomy. The expression of MMP-2 and MMP-9, collagen IV, CD31, CD34, factor VIII, and of smooth muscle cell actin was measured in the samples by morphom...

journal_title：Bulletin of experimental biology and medicine

authors： Murashov IS,Volkov AM,Kazanskaya GM,Kliver EE,Savchenko SV,Klochkova SV,Lushnikova EL

更新日期：2018-10-01 00:00:00

abstract：:We studied the effect of terahertz radiation at NO frequencies 150.176-150.664 GHz on gaseous and electrolyte composition of the blood in albino rats during stress. Partial or complete recovery of the studied parameters of blood gases and electrolytes in stressed animals was observed after 15- and 30-min terahertz irr...

journal_title：Bulletin of experimental biology and medicine

authors： Kirichuk VF,Tsymbal AA

更新日期：2010-12-01 00:00:00

abstract：:We developed a multiplexed DNA microarray-based assay allowing identification of 12 causative agents of reproductive tract infections with the simultaneous detection of 47 genetic determinants of resistance to antimicrobial substances. The microarray was tested on 93 isolates of Neisseria gonorrhoeae, 32 isolates of T...

journal_title：Bulletin of experimental biology and medicine

authors： Leinsoo AT,Shaskol'skii BL,Dement'eva EI,Gryadunov DA,Kubanov AA,Chestkov AV,Obraztsova OA,Shpilevaya MV,Deryabin DG

更新日期：2017-11-01 00:00:00

abstract：:We performed a comparative analysis of biological activity of Lys-Glu peptide and its amino acid constituents. It was established that Lys-Glu stimulated proliferation of splenic cells in organotypic culture, while the mixture of glutamic acid and lysine inhibited culture growth. Using the method of molecular docking,...

journal_title：Bulletin of experimental biology and medicine

authors： Khavinson VKh,Tarnovskaya SI,Lin'kova NS,Chervyakova NA,Nichik TE,Elashkina EV,Chalisova NI

更新日期：2015-02-01 00:00:00

abstract：:Oxidative modification of fibrinogen in acute myocardial infarction increased 1.3-fold compared to that in CHD and 1.5-fold surpassed that in the control without CHD. Elevated content of oxidized fibrinogen correlated with increased levels of LPO products, von Willebrand factor, and fibrin degradation products, with a...

journal_title：Bulletin of experimental biology and medicine

authors： Ragino YI,Baum VA,Polonskaya YV,Sadovski EV,Baum SR,Nikitin YP

更新日期：2008-04-01 00:00:00

abstract：:Changes in cerebral neurogenesis provoked by ischemia and the effect of fluoxetine on this process were studied using a three-vessel occlusion model of global transient cerebral ischemia. The global transient cerebral ischemia was modeled on male Wistar rats by transient occlusion of three major vessels originating fr...

journal_title：Bulletin of experimental biology and medicine

authors： Khodanovich MY,Kisel' AA,Chernysheva GA,Smol'yakova VI,Savchenko RR,Plotnikov MB

更新日期：2016-07-01 00:00:00

abstract：:We studied the effects of potentiated antibodies to morphine and mu-opioid receptors on animal behavior in the forced swimming test and reaction of light avoidance after morphine withdrawal. Antibodies to morphine normalized behavioral characteristics in the forced swimming test, while antibodies to mu-opioid receptor...

journal_title：Bulletin of experimental biology and medicine

authors： Pavlov IF,Epstein OI,Shtark MB

更新日期：2003-01-01 00:00:00

abstract：:Developed form of metabolic syndrome was revealed in 64.3% men with grade 1 obesity and in 81.8% men with grade 2-3 obesity (patients of the therapeutic clinic). The major components were dyslipidemia, fatty hepatosis, arterial hypertension, and hyperinsulinemia. In patients with excess body weight, changes in some bi...

journal_title：Bulletin of experimental biology and medicine

authors： Kogai MA,Lutov UV,Selyatitskaya VG

更新日期：2008-12-01 00:00:00

abstract：:We studied the effect of interleukin-1beta on the behavior of rats with different individual typological characteristics during mild stress in the open-field test. Intraperitoneal injection of interleukin-1beta (5 microg/kg, 108 U/mg) was followed by a decrease in orientation and exploratory activity of passive and, p...

journal_title：Bulletin of experimental biology and medicine

authors： Pertsov SS,Koplik EV,Simbirtsev AS,Kalinichenko LS

更新日期：2009-11-01 00:00:00

abstract：:We studied the effect of experimental liver injury of various origins (toxic, autoimmune, alcoholic, and mesenchymal) in the females on motility of spermatozoa in the offspring. The number of infertile (jerking and immotile) spermatozoa increased, whereas the number of fertile spermatozoa (progressive motile and slow ...

journal_title：Bulletin of experimental biology and medicine

authors： Bryukhin GV,Sizonenko ML

更新日期：2014-11-01 00:00:00

abstract：:We studied the effect of anti-inflammatory cytokine IL-4 (5 μg/kg intraperitoneally) on peripheral blood leukocytes in Wistar rats with various behavioral characteristics during acute emotional stress (1-h immobilization with simultaneous subthreshold electrocutaneous stimulation). IL-4 reduced the differences in bloo...

journal_title：Bulletin of experimental biology and medicine

authors： Pertsov SS,Koplik EV,Kalinichenko LS

更新日期：2015-03-01 00:00:00

abstract：:We studied the role of cAMP- and IKK-2-dependent pathways under conditions of functional stimulation of mesenchymal progenitor cells by basic fibroblast growth factor. An adenylate cyclase inhibitor 2',5'-dideoxyadenosine had no effect on functional activity of early (primitive) mesenchymal precursors. This agent prod...

journal_title：Bulletin of experimental biology and medicine

authors： Zyuz'kov GN,Zhdanov VV,Danilets MG,Udut EV,Miroshnichenko LA,Ligacheva AA,Simanina EV,Chaikovskii AV,Trofimova ES,Minakova MY,Udut VV,Dygai AM

更新日期：2014-06-01 00:00:00

abstract：:Animals were immunized with transmissible gastroenteritis virus conjugated with gold nanoparticles. The resultant antibodies had a higher titer than antibodies produced in response to native virus. Immunization with the antigen-colloidal gold complex led to a significant increase of the peritoneal macrophages respirat...

journal_title：Bulletin of experimental biology and medicine

authors： Staroverov SA,Vidyasheva IV,Gabalov KP,Vasilenko OA,Laskavyi VN,Dykman LA

更新日期：2011-08-01 00:00:00

abstract：:Effects of Miramistin and Phosprenil on biofilms of S. pyogenes, S. aureus, E. coli, L. acidophilus, and L. plantarum were studied. Significant differences in the effects of these substances on mature biofilms of microorganisms and the process of their formation were observed. Miramistin had significant inhibiting eff...

journal_title：Bulletin of experimental biology and medicine

authors： Danilova TA,Danilina GA,Adzhieva AA,Minko AG,Nikolaeva TN,Zhukhovitskii VG,Pronin AV

更新日期：2017-08-01 00:00:00

abstract：:The effect of low dose dichlorodiphenyltrichloroethane (DDT), omnipresent ecotoxicant and endocrine disruptor, on the functioning of the endocrine system is an urgent problem. We studied the effect of low dose DDT on thyroid status in rats. Rats receiving DDT in a dose of 1.890±0.086 μg/kg for 6 weeks showed increased...

journal_title：Bulletin of experimental biology and medicine

authors： Yaglova NV,Yaglov VV

更新日期：2014-04-01 00:00:00