Abstract:
:The effect of low dose dichlorodiphenyltrichloroethane (DDT), omnipresent ecotoxicant and endocrine disruptor, on the functioning of the endocrine system is an urgent problem. We studied the effect of low dose DDT on thyroid status in rats. Rats receiving DDT in a dose of 1.890±0.086 μg/kg for 6 weeks showed increased concentrations of thyroid hormones, particularly triiodothyronine, and reduced level of thyrotropin. Longer exposure reduced the production of thyroid hormones. The dynamics of thyroid status parameters during DDT treatment in a low dose was similar to changes observed during the development of hypothyroidism induced by iodine deficiency.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Yaglova NV,Yaglov VVdoi
10.1007/s10517-014-2443-ysubject
Has Abstractpub_date
2014-04-01 00:00:00pages
760-2issue
6eissn
0007-4888issn
1573-8221journal_volume
156pub_type
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