Abstract:
:The concentrations of proinflammatory cytokines (IL-1beta, IL-6), vascular endothelium growth factor, tumor growth factor-beta, and insulin-like growth factor-1 were measured in the peritoneal fluid of patients with external genital endometriosis and healthy women by enzyme immunoassay. The effect of peritoneal fluid from patients with external genital endometriosis on proliferative activity of EA.Hy926 human endothelial cells was evaluated by the method based on the analysis of cell cycle by flow cytometry. The concentrations of IL-1beta, IL-6, and insulin-like growth factor-1 were increased in patients with endometriosis in comparison with healthy women. The peritoneal fluid from patients with endometriosis (but not from healthy women) significantly increased mitotic activity of endothelial cells and exhibited high angiogenic potential, which can promote implantation and growth of endometrial transplants. Presumably, insulin-like growth factor-1 stimulates this process.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Sokolov DI,Solodovnikova NG,Pavlov OV,Niauri DA,Volkov NN,Sel'kov SAdoi
10.1007/s10517-006-0019-1subject
Has Abstractpub_date
2005-11-01 00:00:00pages
541-4issue
5eissn
0007-4888issn
1573-8221journal_volume
140pub_type
杂志文章abstract::Here we addressed a question of whether gamma oscillations previously described in the whisker-related barrel cortex are a universal pattern of activity in the somatosensory cortex of newborn rats. Intracortical recording of local field potentials and action potentials in neurons using multisite silicon electrodes in ...
journal_title:Bulletin of experimental biology and medicine
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pub_type: 临床试验,杂志文章
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journal_title:Bulletin of experimental biology and medicine
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journal_title:Bulletin of experimental biology and medicine
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