Abstract:
:Muscular dystrophy is a common multisystem disease, which results from the impairment of alternative splicing. An increase in the number of unstable CTG and CCTG repeats in untranslated regions of the DMPK and ZNF9 genes is followed by dysregulation of RNA-binding proteins. Further changes are followed by dysfunction of insulin receptors, membrane Cl- channels, and other proteins. We developed a new mathematical model for the regulation of splicing of exon 11 in the IR gene, which describes the effect of various factors on alternative splicing.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Tonevitsky EA,Trushkin EVdoi
10.1007/s10517-009-0611-2subject
Has Abstractpub_date
2009-06-01 00:00:00pages
772-6issue
6eissn
0007-4888issn
1573-8221journal_volume
147pub_type
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