Abstract：
:Hypoxia tolerance and the intensity of systemic inflammatory response during endotoxemia were examined in newborn, prepubertal, and mature Wistar rats. To assess the sensitivity to hypoxia, the rats were placed into a pressure chamber simulating an altitude of 11,500 m. The systemic inflammatory response was provoked by intraperitoneal injection of LPS from E. coli O26:B6. Serum concentrations of HIF-1α, neopterin, C-reactive protein, and endotoxin were measured. In histological sections of the liver, the area of necrosis was assessed. The smallest tolerance of the prepubertal males to hypoxia correlated with the greatest manifestations of hepatic inflammation and elevated endotoxin, neopterin, and C-reactive protein. Elevation of serum HIF-1α in 3 h after LPC injection was observed in only prepubertal rats. The data obtained should be taken into account during the development of therapeutic strategy for prepubertal children with infectious and inflammatory diseases.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Kosyreva AM,Dzhalilova DS,Tsvetkov IS,Diatroptov ME,Makarova OVdoi
10.1007/s10517-019-04421-3subject
Has Abstractpub_date
2019-03-01 00:00:00pages
699-703issue
5eissn
0007-4888issn
1573-8221pii
10.1007/s10517-019-04421-3journal_volume
166pub_type
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