Blood level of osteonectin in stenosing atherosclerosis and calcinosis of coronary arteries.

Abstract:

:Blood levels of stem cell marker proteins CD34 and osteonectin were studied in male patients with coronary atherosclerosis by direct biomagnetic separation of proteins with magnetic microspheres using the PureProteome Protein A and Protein G Magnetic Beads proteomic technology. High concentration of osteonectin in the blood was detected, particularly in men with stenosing atherosclerosis and coronary artery calcinosis. Blood osteonectin concentration correlated significantly with some key biomarkers of atherosclerosis and with stenosing atherosclerosis and calcinosis of coronary arteries. The results indicate that osteonectin as a marker of stromal stem cells with osteogenic potential presumably plays an important role in atherogenesis and can serve as a new biomarker of stenosing atherosclerosis and calcinosis of coronary arteries.

journal_name

Bull Exp Biol Med

authors

Ragino YI,Kashtanova EV,Chernjavski AM,Volkov AM,Polonskaya YV,Tsimbal SY,Eremenko NV,Ivanova MV

doi

10.1007/s10517-011-1333-9

subject

Has Abstract

pub_date

2011-07-01 00:00:00

pages

370-3

issue

3

eissn

0007-4888

issn

1573-8221

journal_volume

151

pub_type

杂志文章
  • Intraperitoneal Administration of Muramyl Dipeptide β-Heptylglycoside to Pregnant and Non-Pregnant Female Mice Modulates Production of Th1/Th2/Th17/Tr1 Cytokines by Splenocytes Ex Vivo.

    abstract::Muramyl dipeptide β-heptylglycoside (C7MDP) was administered to non-pregnant CBA female mice and pregnant mice after non-abortion-prone mating (CBA×BALB/c) and mating associated with a high rate of spontaneous abortion (CBA×DBA/2). In non-pregnant females, C7MDP increased the production of IL-2, IL-4, IL-5, IL-6, IL-1...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-015-2888-7

    authors: Kalyuzhin OV,Artem'eva KA,Boltovskaya MN,Bunyatyan KA,Inviyayeva EV,Vinnitskii LI,Karaulov AV

    更新日期:2015-05-01 00:00:00

  • Effects of Melatonin, Aluminum Oxide, and Polymethylsiloxane Complex on the Expression of LYVE-1 in the Liver of Mice with Obesity and Type 2 Diabetes Mellitus.

    abstract::The effects of melatonin, aluminum oxide, and polymethylsiloxane complex on the expression of LYVE-1 (lymphatic vessel endothelial hyaluronan receptor) in the liver were studied in db/db mice with experimental obesity and type 2 diabetes mellitus. The complex or placebo was administered daily by gavage from week 8 to ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-016-3592-y

    authors: Michurina SV,Ishchenko IY,Arkhipov SA,Klimontov VV,Rachkovskaya LN,Konenkov VI,Zavyalov EL

    更新日期:2016-12-01 00:00:00

  • Endogenous regulators of NO bioavailability in rats with acute renal failure.

    abstract::We studied the impact of acute glycerol-induced renal failure on blood levels and daily urinary excretion of arginine, monomethylarginine, and asymmetric and symmetric dimethylarginine. Acute renal failure was accompanied by enhanced daily excretion of asymmetric and symmetric dimethylarginine, increased plasma level ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-012-1736-2

    authors: Sukhovershin RA,Gilinsky MA

    更新日期:2012-08-01 00:00:00

  • Proliferation, Migration, and Production of Nitric Oxide by Bone Marrow Multipotent Mesenchymal Stromal Cells from Wistar Rats in Hypoxia and Hyperglycemia.

    abstract::We studied proliferation, migration, and secretion of NO by bone marrow multipotent mesenchymal stromal cells from Wistar rats during conditioning under hypoxic and hyperglycemic conditions and the effect of erythropoietin on these parameters. A stimulating effect of erythropoietin on cell proliferation under normal c...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-015-2986-6

    authors: Lykov AP,Nikonorova YV,Bondarenko NA,Poveshchenko OV,Kim II,Poveshchenko AF,Konenkov VI

    更新日期:2015-08-01 00:00:00

  • Parmacological regulation of erythropoietic precursor pool in experimental neuroses.

    abstract::We studied the effect of bone marrow Thy 1,2+ cells on the growth of erythroid colonies and the role of monoamine in the regulation of proliferation and differentiation of erythroid precursor cells in experimental neuroses. Under conditions of conflict situation Thy 1,2+ cells stimulated the growth of erythropoietic p...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-006-0039-x

    authors: Skurikhin EG,Provalova NV,Pershina OV,Minakova MY

    更新日期:2005-11-01 00:00:00

  • Heart Rhythm Disturbances Caused by Injection of Cholinesterase Inhibitor Physostigmine to Rats during the Early Ontogeny.

    abstract::Parameters of cardiac activity after administration of the cholinesterase inhibitor physostigmine were analyzed in newborn rats and on day 16 of postnatal development. The type of cardiovascular response to acetylcholine excess in newborns and 16-day-old rats were similar, but they significantly differed by the magnit...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-018-4095-9

    authors: Sizonov VА,Dmitrieva LE

    更新日期:2018-05-01 00:00:00

  • Effect of laser radiation on production of reactive oxygen species in the blood of patients with chronic obstructive pulmonary disease.

    abstract::The effect of laser radiation on generation of reactive oxygen species in the whole blood from patients with chronic obstructive pulmonary disease was studied by in vitro recording of luminol-dependent chemiluminescence. Laser irradiation of the blood from patients with increased production of reactive oxygen species ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-007-0299-0

    authors: Farkhutdinov UR,Farkhutdinov ShU

    更新日期:2007-08-01 00:00:00

  • Methodological approaches to deciphering the etiological structure of non-nosocomial pneumonia.

    abstract::Comparative analysis of the efficiency of PCR and microbiological methods for deciphering of the etiological structure of non-nosocomial pneumonias demonstrated the diagnostic significance of detecting Streptococcus pneumoniae DNA in the blood, but not sputum. Mechanisms of penetration of S. pneumoniae into the blood ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1023/b:bebm.0000010969.76881.87

    authors: Artemova LV,Beskhlebnaya VA,Ezhova LG,Kirillov MY,Kravtsov EG,Dalin MV

    更新日期:2003-10-01 00:00:00

  • Pine resin and Biopin ointment: effects on repair processes in tissues.

    abstract::The effects of Biopin (ointment containing pine resin) used in the treatment of burns, wounds, and pyoinflammatory processes on cell composition of the wound surface (smears) and granulation tissue were studied on rats. In vitro antibacterial activity of the drug was also evaluated. At the early stage of inflammation ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1023/a:1019805603373

    authors: Simbirtsev AS,Konusova VG,Mchelidze GSh,Fidarov EZ,Paramonov BA,Chebotarev VY

    更新日期:2002-05-01 00:00:00

  • Subpopulation composition of peripheral blood lymphocytes in children with infectious mononucleosis.

    abstract::In patients with viral and bacterial infectious mononucleosis during the acute period of disease and clinical convalescence blood content of CD72(+)and CD16(+)lymphocytes increased compared to normal. The count of CD8(+)cells increased in viral mononucleosis during convalescence and these changes persist in delayed pe...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1023/a:1020612822959

    authors: Novitskii VV,Urazova OI,Naslednikova IO,Pomogaeva AP,Syusina LV

    更新日期:2002-07-01 00:00:00

  • Modeling of Focal Seizures with Automatisms in Rats with Pendulum Movements.

    abstract::Phenotypical study was carried out in rats with pendulum movements. The animals exhibited a high level of abortive seizures in response to audiogenic stimuli and longer postictal catalepsy in comparison with those in Wistar population. Seizure severity positively correlated with the duration of poststimulus catalepsy ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-019-04695-7

    authors: Alekhina TA,Kozhemyakina RV

    更新日期:2019-12-01 00:00:00

  • Release-activity: a long way from phenomenon to new drugs.

    abstract::Multiple dilutions of the original substance release its peculiar activity referred to as "release-activity". Although this activity originates from the initial substance, it does not depend on its negligible concentration in extreme dilutions. Thus, the terms "dose", "ultralow dose", and "homeopathic dose", do not co...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-012-1874-6

    authors: Epstein OI

    更新日期:2012-11-01 00:00:00

  • Effect of Herbal Homeopathic Monopreparations on the Rate of Tissue Lymphatic Drainage in Healthy Mice.

    abstract::We studied the effects of homeopathic monopreparations of plant origin Atropa Belladonna and Rhus toxicodendron in three dilutions (potencies) on interstitial humoral transport in healthy laboratory mice assessed by the rate of excretion of the lymphotropic label from the mesentery according to the Oyvin's method (vit...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-016-3510-3

    authors: Rodionova OM,Glebov VV,Artamonova EV,Butenin MA,Anikina EV

    更新日期:2016-10-01 00:00:00

  • Differentiation of dissociated rat embryonic brain after allotransplantation into damaged nerve.

    abstract::Fragments of the dorsolateral wall of the anterior brain vesicle from rat embryos on embryonic day 15 were dissociated and the resultant suspension containing single cells and cell aggregates was injected into the proximal segment of crushed sciatic nerve of adult animals for evaluation of their engrafting and differe...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-013-2296-9

    authors: Petrova ES,Isaeva EN,Korzhevskii DE

    更新日期:2013-11-01 00:00:00

  • Correction to: Possibility of Aggravation of Tissue Sclerosis after Injection of Multipotent Mesenchymal Stromal Cells Near the Forming Cicatrix in the Experiment.

    abstract::The author name G. A. Chastikina should read G. A. Chastikin. ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章,已发布勘误

    doi:10.1007/s10517-017-3883-y

    authors: Maiborodin IV,Morozov VV,Anikeev AA,Figurenko NF,Maslov RV,Matveeva VA,Chastikin GA,Maiborodina VI

    更新日期:2017-09-01 00:00:00

  • Vitamin B-complex initiates growth and development of human embryonic brain cells in vitro.

    abstract::We studied a combined effect of subcomponents of vitamin B complex on the growth, development, and death of human embryonic brain-derived cells (E90) cultured using a modified method of Matson. Cell death was detected by trypan blue staining. According to our results, vitamin B-complex in low-doses promote the develop...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-011-1387-8

    authors: Danielyan KE,Abramyan RA,Galoyan AA,Kevorkian GA

    更新日期:2011-09-01 00:00:00

  • Changes in the concentration of tissue inhibitor of type 1 metalloproteinases in blood serum and liver of mice with CCl4-induced hepatitis.

    abstract::The concentration of tissue inhibitor of type 1 metalloproteinases in blood serum from intact CBA mice measured by enzyme immunoassay is similar to that in healthy humans. The concentration of tissue inhibitor of type 1 metalloproteinases in mouse bile was higher than in blood serum, while its concentration in liver h...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-007-0098-7

    authors: Korolenko TA,Filatova TG,Savchenko NG,Yuz'ko YV,Goncharova IA,Alexeenko TV

    更新日期:2007-03-01 00:00:00

  • Role of Copper Dyshomeostasis in the Pathogenesis of Parkinson's Disease.

    abstract::Serum concentration of copper, immunoreactive polypeptides of ceruloplasmin and its oxidase activity, and the number of copper atoms per ceruloplasmin molecule were decreased in patients with Parkinson's disease in comparison with the corresponding parameters in age-matched healthy individuals, but the ratio of apocer...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-018-4039-4

    authors: Karpenko MN,Ilyicheva EY,Muruzheva ZM,Milyukhina IV,Orlov YA,Puchkova LV

    更新日期:2018-03-01 00:00:00

  • Hormonal reaction of the testes to chorionic gonadotropin in CBA/Lac and PT mice: effects of the dose and time after treatment.

    abstract::Testosterone concentrations in the blood of CBA/Lac and PT mice and its content in the testes under normal conditions and during stimulation with chorionic gonadotropin were measured by enzyme immunoassay. Genetic differences in reactivity of the testes to chorionic gonadotropin were revealed: PT mice were characteriz...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-010-1112-z

    authors: Dubovenko EA,Osadchuk LV

    更新日期:2010-12-01 00:00:00

  • Effect of Interchain Disulfide Crosslinking in the Tropomyosin Molecule on Actin-Myosin Interaction in the Atrial Myocardium.

    abstract::Tropomyosin (Tpm) is one of the main regulatory proteins in the myocardium. In some heart pathologies, interchain disulfide crosslinking in the Tpm molecule occurs. In the ventricle, this change in the structural properties of the Tpm molecule affects calcium regulation of the actin-myosin interaction. Using an in vit...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-019-04462-8

    authors: Shchepkin DV,Matyushenko AM,Bershitsky SY,Kopylova GV

    更新日期:2019-05-01 00:00:00

  • Cryoglobulin composition in patients with myocardial infarction.

    abstract::The formation of an ischemic focus in the myocardium is paralleled by autoimmune processes involving immunoglobulins with abnormal thermal solubility, cryoglobulins. Serum levels of cryoglobulins and their complexes were measured in 25 patients with Q-forming myocardial infarction on days 1, 2, 3, 7, and 14 of the dis...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-011-1155-9

    authors: Konstantinova NA,Yeremin II,Konstantinova EV,Karandashov EN,Shostak NA

    更新日期:2011-02-01 00:00:00

  • Nitroxide synthase activities at different stages of adjuvant arthritis.

    abstract::The location and activities of nitric oxide synthases in synovial cells during different stages of inflammatory process were studied by the immunocytochemical method in animals with experimental rheumatoid arthritis. Direct involvement of the NOergic mechanisms in the development of adjuvant arthritis was demonstarted...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-007-0203-y

    authors: Belogolovykh LA,Dubikov AI,Medved' EE

    更新日期:2007-05-01 00:00:00

  • Role of receptors to fibroblast growth factor (FGF) on mesenchymal precursor cells in the realization of regenerative effects of alkaloid songorine.

    abstract::We studied the mechanisms of regenerative (wound healing) effects of songorine associated with functional activation of mesenchymal progenitor cells. The key role of FGF receptors on these progenitor cells in the stimulation of realization of their growth potential under the effect of the alkaloid was demonstrated. Un...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-014-2511-3

    authors: Zyuz'kov GN,Chaikovskii AV,Ligacheva AA,Zhdanov VV,Udut EV,Danilets MG,Miroshnichenko LA,Simanina EV,Suslov NI,Losev EA,Trofimova ES,Povet'eva TN,Nesterova YV,Fomina TI,Minakova MY,Dygai AM

    更新日期:2014-05-01 00:00:00

  • Involvement of Wulst neurons in hiding reaction of pied flycatcher nestlings with different visual afferentation.

    abstract::We studied transcriptional activity in the higher avian center visual system (Wulst area) in acoustically guided defensive behavior in visually deprived and non-deprived nestlings to evaluate the effects of visual afferentation on functional involvement of visual structures in acoustically guided defensive behavior. E...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-012-1781-x

    authors: Korneeva EV,Tiunova AA,Alexandrov LI

    更新日期:2012-09-01 00:00:00

  • Effect of epithalamin on circadian relationship between the endocrine function of the thymus and melatonin-producing function of the pineal gland in elderly people.

    abstract::The effect of epithalamin on circadian rhythms of thymic serum factor titers and melatonin concentrations in the blood of elderly people was studied. Course treatment with epithalamin modulated the rhythm of the thymic endocrine function. The increase in the titer of thymic serum factor at night coincided with the inc...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1023/b:bebm.0000038165.09563.b5

    authors: Labunets IF,Butenko GM,Magdich LV,Korkushko OV,Khavinson VKh,Shatilo VB

    更新日期:2004-05-01 00:00:00

  • Contribution of the complement system to realization of biological fluid cytotoxicity in health and disease.

    abstract::The cytotoxic effects of human blood serum were studied under normal and pathological conditions. The contribution of the complement system to the realization of this effect was demonstrated. Significant differences in the serum capacity to kill foreign cells were detected for healthy subjects and asthmatics. Bovine s...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-012-1791-8

    authors: Arkhipova EN,Cherepov AB,Medvedeva YS,Alchinova IB,Karganov MY

    更新日期:2012-09-01 00:00:00

  • Matrix metalloproteinases 7 and 9 and their types 1 and 4 tissue inhibitors in tumors and plasma of patients with colorectal cancer.

    abstract::Enzyme immunoassays showed significantly elevated content of matrix metalloproteinase 7 and type 1 tissue inhibitor of metalloproteinases in tumors compared to adjacent histologically unchanged mucosa of patients with colorectal cancer; the levels of metalloproteinase 9 and type 4 tissue inhibitor of metalloproteinase...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-007-0156-1

    authors: Gershtein ES,Korotkova EA,Shcherbakov AM,Prorokov VV,Golovkov DA,Kushlinskii NE

    更新日期:2007-04-01 00:00:00

  • Count and phagocytic activity of leukocytes in rats with experimental depressive syndrome caused by systemic administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

    abstract::Leukocyte count decreased, relative content of neutrophils and monocytes increased, and their phagocytic activity was suppressed in rats with 1-methyl-4-phenyl-1,2,3,4-tetrahydropyridine-induced depressive syndrome at the stage of acute behavioral depression. The severity of behavioral depression inversely correlated ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:

    authors: Krupina NA,Davydova TV,Fomina VG,Kryzhanovskii GN,Orlova IN

    更新日期:2000-11-01 00:00:00

  • Bioactive 5-reduced 16 alpha,17 alpha-cyclohexanoprogesterone derivatives weakly interact with proteins of the soluble uterine fraction.

    abstract::We studied competitive activities of 16 alpha,17 alpha-cyclohexano-5 alpha- and 5 beta-dihydroprogesterone in replacing(3)H-progesterone and(3)H-16 alpha,17 alpha-cyclohexano-6 alpha-methylprogesterone from protein complexes. Direct binding of(3)H-5-reduced derivatives with proteins of soluble fractions from rat and r...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1023/a:1017647331285

    authors: Smirnov AN,Pokrovskaya EV,Levina IS,Kulikova LE,Kamernitskii AV,Shevchenko VP

    更新日期:2001-03-01 00:00:00

  • Interaction of Lymphocytes with Mesenchymal Stem Cells.

    abstract::We studied the interaction of neural stem cells and dental pulp-derived mesenchymal stem cells with lymphocytes from autologous and heterologous donors. Flow cytometry analysis with the use of CFSE-labeled lymphocytes demonstrated an increase in the content of proliferating CD8, CD16 and CD56 cells, but not CD4 cells ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-016-3463-6

    authors: Svirshchevskaya EV,Poltavtseva RA,Beletskii IP,Selezneva II,Savilova AM,Sukhikh GT

    更新日期:2016-08-01 00:00:00