Abstract:
:We studied the effect of increased systemic levels of the proinflammatory cytokine IL-1β on the vasomotor reactions of pial microvessels in anesthetized rats under conditions of experimentally simulated progressively increasing acute normobaric hypoxia. Vital microscopy showed that more pronounced dilatation of pial vessels in response to IL-1β under hypoxic conditions was almost completely prevented by pretreatment with non-specific NO synthase blocker L-NAME. These findings indicate the involvement of NO-dependent mechanisms in the vasodilator effect of proinflammatory cytokines under conditions of acute hypoxic exposure.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Mel'nikova NN,Baranova EV,Aleksandrova NPdoi
10.1007/s10517-020-04992-6subject
Has Abstractpub_date
2020-11-01 00:00:00pages
1-4issue
1eissn
0007-4888issn
1573-8221pii
10.1007/s10517-020-04992-6journal_volume
170pub_type
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