Abstract：
:We revealed some relationships between the level of orientation and exploratory behavior, functional activity of the immune system, and structural and functional organization of the CNS in animals. Significant differences in brain morphology and expression of cytokine IL-1 beta, type I IL-1 receptor, and erythropoietin receptor genes in brain cells were detected in (CBA x C57Bl/6)F1 mice with different initial levels of orientation and exploratory behavior. Immunocompetent cells of mice with high and low levels of exploratory behavior differ by spontaneous and mitogen-induced proliferative activity. The formation of humoral and cellular immune response in these animals causes opposite changes in exploratory behavior and the type of these changes depends on the initial level of this behavioral reaction.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Markova EV,Chernova TG,Fillimonov PN,Korotkova NA,Abramov VV,Kozlov VAdoi
10.1007/s10517-005-0057-0subject
Has Abstractpub_date
2004-10-01 00:00:00pages
415-7issue
4eissn
0007-4888issn
1573-8221pii
doijournal_volume
138pub_type
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