Abstract：
:The mechanisms underlying cardioprotective activity of compound ALM-802 were studied in experiments on rats with chronic post-infarction heart failure. Real-time PCR showed that compound ALM-802 (daily intraperitoneal injections in a dose of 2 mg/kg for 28 days starting from day 91 after myocardial infarction modeling) restored the expression of genes encoding β1- (p=0.00001) and β2-adrenoreceptors (p=0.01) and type 2 ryanodine receptors (p=0.008) in the myocardium that was reduced in control animals. These effects can serve as the basis for the ability of the compound to reduce the intensity of remodeling and increase the inotropic function of the left heart ventricle shown earlier in this model.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Kozhevnikova LM,Barchukov VV,Semenova NP,Vititnova MB,Kryzhanovskii SAdoi
10.1007/s10517-021-05058-xsubject
Has Abstractpub_date
2021-01-01 00:00:00pages
312-315issue
3eissn
0007-4888issn
1573-8221pii
10.1007/s10517-021-05058-xjournal_volume
170pub_type
杂志文章abstract：:We studied the effect of mesenchymal stromal cells and conditioned media on healing of full-thickness skin wound in rats. Cell transplantation to the wound bed did not accelerate wound closing and had no effect on the severity of inflammation, but increased vasculariza - tion of the granulation tissue in 14 days after...
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