Abstract:
:The C-terminal fragment Pro-Gly-Pro of semax does not modulate the development of symptoms of neurological deficiency and mortality in rats with incomplete global cerebral ischemia. Hence, previously revealed neuroprotective effects of semax are mainly determined by corticotropin ACTH4-7 fragment.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Fadyukova OE,Kadi A,Bai O,Andzhusheva GM,Koshelev VBdoi
10.1007/s10517-005-0311-5subject
Has Abstractpub_date
2005-04-01 00:00:00pages
421-3issue
4eissn
0007-4888issn
1573-8221pii
doijournal_volume
139pub_type
杂志文章abstract::Digital simulation of disorders in the p53 and Mdm2 protein system, involved in repair of DNA defects and in many vital processes, including tumor formation, neurodegeneration, and aging, was carried out on the base of functional nonlinear octoparametric mathematical model. Stress situations were studied, associated w...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-014-2608-8
更新日期:2014-08-01 00:00:00
abstract::Mice lacking dynein arms in the cilia were examined; the strain was obtained by inactivation of dynein heavy chain gene in chromosome 7. The cilia of these mice were examined by electron microscopy and compared to the cilia of random-bred mice. No statistically significant differences or typical disorders in the outer...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1023/b:bebm.0000042727.67636.b3
更新日期:2004-06-01 00:00:00
abstract::Comparative study of cultured human bone marrow and adipose tissue (lipoaspirate) mesenchymal stem cells was carried out. The main morphological parameters, proliferative activity, expression of surface and intracellular markers of these cells were characterized. Flow cytofluorometry and histological staining showed t...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-005-0430-z
更新日期:2005-07-01 00:00:00
abstract::Studies of the molecular mechanisms of esophageal cancer development have to be carried out on sufficient amount of tumor material, obtained under conditions of controlled exposure to carcinogenic factors. Esophageal cancer models on laboratory animals serve an indispensable source of this material. One of these model...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-018-4057-2
更新日期:2018-03-01 00:00:00
abstract::Cytochemical activity of succinate dehydrogenase and lactate dehydrogenase in blood lymphocytes, activity of hydroperoxides, MDA, and blood plasma antioxidants were studied in experimental animals during immobilization stress after preliminary injection of doxazosin. Preliminary adrenergic receptor blockade prevented ...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-005-0064-1
更新日期:2004-11-01 00:00:00
abstract::Antibacterial activity of powdered preparations based on copper and silver nanoparticles was compared with activity of the reference preparation Baneocin on the model of local staphylococcal infection in white rats. The developed preparations exhibited pronounced antibacterial activity against methicillin-resistant S....
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-019-04622-w
更新日期:2019-10-01 00:00:00
abstract::Groups of microRNA genes, methylation of which is associated with the initial (I-II) stages of breast cancer, are determined, and new markers and marker systems for the disease diagnosis were created on the basis of these data. A total of 14 genes in which methylation was associated with breast cancer were identified ...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-019-04691-x
更新日期:2019-12-01 00:00:00
abstract::We studied processes of proliferation and differentiation of hemopoietic precursor cells in mice treated with granulocyte CSF under conditions of cytostatic myelodepression. It was found that the hemostimulating effect of original granulocyte CSF preparation consists in accelerated maturation of hemopoietic precursors...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-005-0235-0
更新日期:2005-01-01 00:00:00
abstract::We studied the effect of subbacteriostatic azithromycin concentrations on the formation of microbial biofilms by Pseudomonas aeruginosa strains that caused implant-associated infection of large joints. Azithromycin in subinhibitory for planktonic cells concentrations 0.01-0.02 μg/ml stimulated biofilm formation by bot...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-020-04982-8
更新日期:2020-10-01 00:00:00
abstract::Autooxidation of low-density lipoproteins during incubation at 37 degrees C was accompanied by accumulation of LPO products, decrease in UV autofluorescence (FUV), and increase in autofluorescence in the visible band (FVIS). The degree of low-density lipoprotein modification was estimated by calculating the FVIS/FUV r...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-006-0385-8
更新日期:2006-10-01 00:00:00
abstract::We compared analgesic activities of individual alkaloids extracted from Baikal aconite (Aconitum baikalensis): napelline, hypaconitine, songorine, mesaconitine, 12-epinapelline N-oxide. The detected analgesic activity was comparable to that of sodium metamizole. The mechanisms of analgesia were different in diterpene ...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-014-2598-6
更新日期:2014-08-01 00:00:00
abstract::The efficiency of drug therapy should be evaluated by not only its directed action on specific organ or target parameter, but also its effects on general regulatory and adaptive status. ...
journal_title:Bulletin of experimental biology and medicine
pub_type: 临床试验,杂志文章
doi:10.1007/s10517-008-0195-2
更新日期:2008-06-01 00:00:00
abstract::Biochemiluminescence increased, while aconitate hydratase activity and citrate accumulation in tissues of the liver and heart and blood decreased in rats with experimental hyperthyroidism. These changes reflect activation of free radical oxidation, damage to enzyme molecules with reactive oxygen species, and impaired ...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-007-0289-2
更新日期:2007-08-01 00:00:00
abstract::We studied the effect of continuous vibration and treatment with licorice root (Glycyrrhiza glabra L.) on peripheral blood red cells in rabbits. Active substances of licorice root accelerated metabolism in cells of the bone marrow erythroid stem, enhanced compensatory reserve of the organism, and increased animal's re...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-005-0444-6
更新日期:2005-08-01 00:00:00
abstract::Myocardial remodeling in SHR rats with age-related hypertrophy was characterized by elimination of cardiomyocytes, their hypertrophy, and marked increase in the volume of the connective tissue. The count of cardiomyocytes with contracture injuries and subsegmental contractures increased, and pronounced perivascular an...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1023/a:1023836318560
更新日期:2003-02-01 00:00:00
abstract::We studied electrophysiological parameters and morphological changes in the adrenal glands and spleen of CBA mice feeding a low-choline diet and/or ethanol-containing diet. The polarization coefficient underwent similar changes in the adrenal glands and spleen, which was associated with different contribution of imped...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-006-0009-3
更新日期:2005-11-01 00:00:00
abstract::Experimental simulation of burn was followed by accumulation of LPO products and suppression of antioxidant enzyme activity in the burn wound. Application of a synthetic analogue of indolicidin led to an increase in MDA and acylhydroperoxide concentrations in the burn wound on experimental day 1. Further application o...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-014-2587-9
更新日期:2014-08-01 00:00:00
abstract::The levels of natural antibodies to β-endorphin, bradykinin, histamine, dopamine, and serotonin were measured in 271 cardiological patients in order to evaluate the severity of their clinical status. The patients were distributed into groups differing by the course of the pathological process. The levels of natural an...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-017-3739-5
更新日期:2017-05-01 00:00:00
abstract::We studied the effects of potentiated antibodies to morphine and mu-opioid receptors on animal behavior in the forced swimming test and reaction of light avoidance after morphine withdrawal. Antibodies to morphine normalized behavioral characteristics in the forced swimming test, while antibodies to mu-opioid receptor...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1023/a:1024754007698
更新日期:2003-01-01 00:00:00
abstract::The incidence of mutations in the BRCA1 and BRCA2 genes in the studied sampling of 74 patients with ovarian cancer was 19%. The incidence of mutations in the Russian sampling of patients, formed without consideration for the family history, is one of the highest in European countries. Retrospective analysis showed tha...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-007-0261-1
更新日期:2007-07-01 00:00:00
abstract::Biopsy specimens from patients with psoriasis treated with antiproliferative drugs (methotrexate, etretinate) were analyzed. Acanthosis and papillomatosis of the epidermis and inflammatory reaction of the derma decreased. A tendency to normalization of epidermocyte ultrastructure with regeneration of tonofilaments and...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1023/a:1013054601066
更新日期:2001-08-01 00:00:00
abstract::We performed a comparative study of the localization, distribution, metabolic activity, and surface properties of human bone marrow mesenchymal stromal cells after static and perfusion seeding to macroporous alginate cryogels. A simple perfusion system for mesenchymal stromal cell seeding to macroporous alginate cryog...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-011-1185-3
更新日期:2011-02-01 00:00:00
abstract::We studied ultrastructure of nuclear compartment in cardiomyocytes during regenerative and plastic insufficiency of the myocardium induced by anthracycline antibiotic daunomycin. A peculiarity of ultrastructural organization of cardiomyocyte nuclei under these conditions is almost complete disappearance of the heteroc...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:
更新日期:2000-12-01 00:00:00
abstract::Neurospecific proteins S-100 and GFAP were measured in the serum of 145 patients with neural tumors and 69 healthy individuals. In patients with glyoblastomas, the concentrations of S-100 and GFAP were significantly higher than in patients with anaplastic astrocytomas, benign meningiomas, and brain metastases and in h...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-011-1236-9
更新日期:2011-04-01 00:00:00
abstract::The role of extracellular matrix enzymes in the development of distant metastases of colorectal cancer was studied. The expression of types 2 and 9 matrix metalloproteinases was evaluated in primary colorectal adenocarcinomas (264 patients) and their metastases in the lymph nodes (127 patients) and liver (109 patients...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-009-0507-1
更新日期:2009-03-01 00:00:00
abstract::Anticonvulsant activity and pharmacokinetics of nanoemulsion and unmodified substance of carbamazepine were compared in experiments on mice. Carbamazepine nanoemulsion demonstrated significant anticonvulsant activity and was superior to unmodified substance of carbamazepine against seizures induced by maximum electric...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-014-2657-z
更新日期:2014-10-01 00:00:00
abstract::We studied the peculiarities of oxidative and substrate phosphorylation in isolated cardiomyocytes and myocardial mitochondria in 2- and 15-month-old rats. It was shown that age factor reduces the degree of oxidation and phosphorylation coupling both in cardiomyocytes and in mitochondria, which was associated with the...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-019-04547-4
更新日期:2019-08-01 00:00:00
abstract::We studied morphological changes in rat abdominal aorta and vena cava inferior induced by endovascular microwave destruction. This treatment induced thrombosis and necrosis of the vascular walls, but fibrous framework was not completely destroyed. Then we observed irreversible changes in vessels: obliteration, atrophy...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1023/a:1020633427502
更新日期:2002-07-01 00:00:00
abstract::We studied a biomaterial for a new domestic product, a biological envelope for implantation of cardiac electronic devices. The product is designed to prevent complications after pacemaker implantation and to facilitate the reimplantation procedure. By chemical and biological processing of raw materials (submucosa of p...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-020-04712-0
更新日期:2020-01-01 00:00:00
abstract::The number of CD3(+)CD56-HLA-G(+) cells in the peripheral blood of breast cancer patients was shown to increase by 2 times. Our results and published data suggest that the increase in the relative content of CD3(+)CD56-HLA-G(+) cells in the circulating blood in breast cancer contributes to tumor development due to sup...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-015-3038-y
更新日期:2015-09-01 00:00:00