Antileprosy activity and preliminary toxicological characteristics of some dialkyldithiocarbamate derivatives.

abstract：:Infection of surfagon (gonadotropin-releasing hormone analog) in a dose of 0.1 microg/kg to male CBA mice stimulated lymphocyte migration from splenic B zones, caused moderate thinning of the thymic cortex, thickening of the zona fasciculata of the adrenal cortex with signs of corticocyte activation. After administrat...

journal_title：Bulletin of experimental biology and medicine

authors： Bobyntsev II,Dolzhikov AA,Severyanova LA

更新日期：2005-01-01 00:00:00

abstract：:We compared analgesic activities of individual alkaloids extracted from Baikal aconite (Aconitum baikalensis): napelline, hypaconitine, songorine, mesaconitine, 12-epinapelline N-oxide. The detected analgesic activity was comparable to that of sodium metamizole. The mechanisms of analgesia were different in diterpene ...

journal_title：Bulletin of experimental biology and medicine

authors： Nesterova YV,Povet'yeva TN,Suslov NI,Zyuz'kov GN,Pushkarskii SV,Aksinenko SG,Schultz EE,Kravtsova SS,Krapivin AV

更新日期：2014-08-01 00:00:00

abstract：:The kinetics of thrombin inhibition by irons ions was studied in the thrombin time test with normal plasma. The kinetic and concentration characteristics for recovery of thrombin activity by desferal were evaluated at various periods of thrombin incubation with iron ions. The thrombin time test showed that incubation ...

journal_title：Bulletin of experimental biology and medicine

authors： Azizova OA,Shvachko AG,Aseichev AV

更新日期：2009-11-01 00:00:00

abstract：:We propose a method of creation of a 3D matrix consisting of native collagen fibers and natural polysaccharide chitosan. The collagen-chitosan hydrogels maintain viability and prolipherative activity of embryonic stem cells obtained from internal cells of mouse blastocyst. The proposed system forming hydrogels in situ...

journal_title：Bulletin of experimental biology and medicine

authors： Selezneva II,Savintseva IV,Vikhlyantseva EF,Davydova GA,Gavrilyuk BK

更新日期：2006-07-01 00:00:00

abstract：:The cytotoxic effects of human blood serum were studied under normal and pathological conditions. The contribution of the complement system to the realization of this effect was demonstrated. Significant differences in the serum capacity to kill foreign cells were detected for healthy subjects and asthmatics. Bovine s...

journal_title：Bulletin of experimental biology and medicine

authors： Arkhipova EN,Cherepov AB,Medvedeva YS,Alchinova IB,Karganov MY

更新日期：2012-09-01 00:00:00

abstract：:Pro-Gly-Pro and its metabolite Gly-Pro effectively prevented the development of erosive and ulcerative lesions of the gastric mucosa in rats under conditions of water-immersion restraint stress by restoring the oxidatant-antioxidant balance in the total fraction of gastric mucosa cells. Pro-Gly was least effective in ...

journal_title：Bulletin of experimental biology and medicine

authors： Falalyeyeva TM,Samonina GE,Beregovaya TV,Andreeva LA,Dvorshchenko EV

更新日期：2010-07-01 00:00:00

abstract：:We studied the effects of stress exposure during the adolescent period of development (SAPD) on the parameters of inflammatory painful response and the level of depression-like behavior in prenatally stressed adult male rats. In addition, we analyzed the effects of selective serotonin (5-HT) reuptake inhibitor fluoxet...

journal_title：Bulletin of experimental biology and medicine

authors： Butkevich IP,Mikhailenko VA

更新日期：2020-07-01 00:00:00

abstract：:The effect of melanin solutions on the skin exposed to UV irradiation (1,050 kJ/m(2)) depended on its dose and varied from photoprotection (0.005 mg/ml) to photosensitization and phototoxicity (burn, 0.1 mg/ml). These results suggest that doses of melanin preparations should be empirically selected to achieve optimum ...

journal_title：Bulletin of experimental biology and medicine

authors： Paramonov BA,Turkovskii II,Potokin IL,Chebotarev VY

更新日期：2002-04-01 00:00:00

abstract：:We studied the effects of selective delta-opiate receptor agonists and antagonists on the phosphoinositide pathway in lymphocytes from healthy donors and patients with diabetes mellitus. The test compounds probably play a role in changes in the sensitivity to pharmacological substances binding to delta-opiate receptor...

journal_title：Bulletin of experimental biology and medicine

authors： Agadjanov MI,Vartanian GS,Tadevosyan YV,Batikyan TB,Agadjanova EM

更新日期：2004-02-01 00:00:00

abstract：:The tissue engineering construction was developed from human bone marrow multipotent stromal cells and 3D porous foamed-ceramic carriers of a zirconium oxide-aluminum oxide system. The carriers had no cytotoxic activity and were potent in maintaining the cell adhesion and proliferation. We developed the method for ino...

journal_title：Bulletin of experimental biology and medicine

authors： Bukharova TB,Fatkhudinov TKh,Tsedik LV,Ilyushchenko AF,Goldshtein DV

更新日期：2009-01-01 00:00:00

abstract：:The content of low-molecular-weight components in blood serum was studied by tandem mass-spectrometry in pregnant women. Serum metabolic profiles of patients with a grave obstetrical history were detected. The most significant changes were observed for the concentrations of low-molecular-weight substances involved in ...

journal_title：Bulletin of experimental biology and medicine

authors： Khaustova SA,Senyavina NV,Tonevitsky AG,Eremina OV,Pavlovich SV

更新日期：2013-11-01 00:00:00

abstract：:A cascade of pathological changes in the intact hemisphere developed in rats 6 months after focal unilateral traumatic brain injury: neuronal degeneration, hyperexpression of α-synuclein, APP (β-amyloid peptide precursor) protein, and glutamine synthetase in cells other than astrocytes. The development of these change...

journal_title：Bulletin of experimental biology and medicine

authors： Genrikhs EE,Voronkov DN,Kapkaeva MR,Isaev NK,Stelmashook EV

更新日期：2017-12-01 00:00:00

abstract：:We studied the influence of pretreatment with chemical mildronate analogue sibusol on the course of experimental gastric ulcer in rats. Sibusol produced a protective effects on the stomach and duodenum. ...

journal_title：Bulletin of experimental biology and medicine

authors： Lychkova AE,Savchuk VI,Smirnov VM

更新日期：2004-01-01 00:00:00

abstract：:We studied competitive activities of 16 alpha,17 alpha-cyclohexano-5 alpha- and 5 beta-dihydroprogesterone in replacing(3)H-progesterone and(3)H-16 alpha,17 alpha-cyclohexano-6 alpha-methylprogesterone from protein complexes. Direct binding of(3)H-5-reduced derivatives with proteins of soluble fractions from rat and r...

journal_title：Bulletin of experimental biology and medicine

authors： Smirnov AN,Pokrovskaya EV,Levina IS,Kulikova LE,Kamernitskii AV,Shevchenko VP

更新日期：2001-03-01 00:00:00

abstract：:Pronounced changes in the capillaries, hemodynamic disorders, epitheliocyte degeneration and atrophy develop in the buccal mucosa of patients with types I and II diabetes mellitus in the absence of inflammatory cellular infiltration or with facultative infiltration. The morphogenesis of pathological changes can be reg...

journal_title：Bulletin of experimental biology and medicine

authors： Balakhonov LV,Nepomnyashchikh LM,Aidagulova SV,Bakarev MA,Vlasova LF

更新日期：2006-11-01 00:00:00

abstract：:We studied the effect of allotransplantation of bone marrow mononuclear cells on postinfarction remodeling of the heart in rats. The cells were transplanted into the periinfarction zone of the heart. The transplantation was performed on day 9 after coronary occlusion. It was found that on day 45 after coronary occlusi...

journal_title：Bulletin of experimental biology and medicine

authors： Maslov LN,Shakhov VP,Krylatov AV,Platonov AA

更新日期：2008-01-01 00:00:00

abstract：:Isolation and identification of rat brain protein regulated by serotonin-modulated protein SMP-69 is described. Intracerebral administration of anti-SMP-69 antibodies activates cerebral cortex cell genome and increases the content of electropheretic fraction 28. Intracerebral administration of isolated and purified pr...

journal_title：Bulletin of experimental biology and medicine

authors： Mekhtiev AA

更新日期：2000-08-01 00:00:00

abstract：:Experiments on male and female CC57BR/Mv mice differing by the sensitivity to carcinogenic effect of urethane on the lungs showed that castration 1 week before carcinogen challenge reduced the number of lung adenomas caused by it in males and somewhat increased the number of tumors in females. Exogenous testosterone a...

journal_title：Bulletin of experimental biology and medicine

authors： Morozkova TS,Kaledin VI

更新日期：2015-10-01 00:00:00

abstract：:We studied the effects of phenazepam (0.075 mg/kg) after pretreatment (5 minutes before) with naloxone (10 mg/kg) on open-field behavior of C57Bl/6 and BALB/c mice. In ex vivo experiments, we studied the effects of naloxone (1 and 10 mg/kg) on receptor binding of [(3)H]-flunitrazepam by membranes of brain fraction (P1...

journal_title：Bulletin of experimental biology and medicine

authors： Seredenin SB,Nadorova AV,Kolik LG,Yarkova MA

更新日期：2013-07-01 00:00:00

abstract：:The author name G. A. Chastikina should read G. A. Chastikin. ...

journal_title：Bulletin of experimental biology and medicine

authors： Maiborodin IV,Morozov VV,Anikeev AA,Figurenko NF,Maslov RV,Matveeva VA,Chastikin GA,Maiborodina VI

更新日期：2017-09-01 00:00:00

abstract：:Rat liver was examined by transmission electron microscopy after a single intravenous injection of nanosized magnetite suspension (0.1 g (Fe(3)O(4))/kg body weight). Magnetite particles were found in Kupffer's cells and hepatocytes. Accumulation of the particles by these two cell types was different. Morphometry of ma...

journal_title：Bulletin of experimental biology and medicine

authors： Mil'to IV,Sukhodolo IV,Miller AA

更新日期：2012-08-01 00:00:00

abstract：:Comparative study of cultured human bone marrow and adipose tissue (lipoaspirate) mesenchymal stem cells was carried out. The main morphological parameters, proliferative activity, expression of surface and intracellular markers of these cells were characterized. Flow cytofluorometry and histological staining showed t...

journal_title：Bulletin of experimental biology and medicine

authors： Romanov YA,Darevskaya AN,Merzlikina NV,Buravkova LB

更新日期：2005-07-01 00:00:00

abstract：:Muramyl dipeptide β-heptylglycoside (C7MDP) was administered to non-pregnant CBA female mice and pregnant mice after non-abortion-prone mating (CBA×BALB/c) and mating associated with a high rate of spontaneous abortion (CBA×DBA/2). In non-pregnant females, C7MDP increased the production of IL-2, IL-4, IL-5, IL-6, IL-1...

journal_title：Bulletin of experimental biology and medicine

authors： Kalyuzhin OV,Artem'eva KA,Boltovskaya MN,Bunyatyan KA,Inviyayeva EV,Vinnitskii LI,Karaulov AV

更新日期：2015-05-01 00:00:00

abstract：:We studied the effect of zoledronic acid encapsulated into liposomes (L-ZOL) on tumorassociated macrophages in the stroma of hepatocellular carcinoma xenograft. Liposomes were prepared from 1,2-dipalmitoyl-sn-glycero-3-phosphocholine, 1,2-dipalmitoyl-snglycero-3-phospho-sn-1-glycerol, and 1,2-distearoyl-sn-glycero-3-p...

journal_title：Bulletin of experimental biology and medicine

authors： Wu S,Lin X,Cui X

更新日期：2020-11-01 00:00:00

abstract：:Electron microscopy of the pineal gland in gamma-irradiated rats treated with epithalon revealed ultrastructural signs attesting to enhancement of its functional activity. ...

journal_title：Bulletin of experimental biology and medicine

authors： Khavinson VK,Yakovleva ND,Popuchiev VV,Kvetnoi IM,Manokhina RP

更新日期：2001-01-01 00:00:00

abstract：:We studied the possibility of reproducing syringomyelia in rabbits by injection of serum from patients with syringomyelia. Clinical signs of syringomyelia and morphological changes in the central nervous system (cavities, dilatation of the cerebrospinal channel, neurodegeneration, gliosis) developed in laboratory anim...

journal_title：Bulletin of experimental biology and medicine

authors： Mirsayev TR,Borisova NA

更新日期：2007-04-01 00:00:00

abstract：:Potential created by electrogenic ionic pumps under conditions of maximum activation in a warm standard ionic medium with K(+) after preincubation in cold potassium-free solution has two components: a higher ouabaine-insensitive "stationary" component, and a lower "regulatory" component sensitive to ouabaine, furosemi...

journal_title：Bulletin of experimental biology and medicine

authors： Volkov EM,Sabirova AR,Nurullin LF,Zefirov AL

更新日期：2006-12-01 00:00:00

abstract：:Antisense oligonucleotide to alpha2A-adrenoceptors increased the levels of mRNA (reverse polymerase chain reaction) and protein for a key executioner protease of apoptosis caspase-3 (immunoblotting assay) in the cerebral cortex of newborn rats. The relationship between the observed effect and low expression of alpha2-...

journal_title：Bulletin of experimental biology and medicine

authors： Men'shanov PN,Bannova AV,Il'inykh FA,Dygalo NN

更新日期：2007-03-01 00:00:00

abstract：:The incidence of mutations in the BRCA1 and BRCA2 genes in the studied sampling of 74 patients with ovarian cancer was 19%. The incidence of mutations in the Russian sampling of patients, formed without consideration for the family history, is one of the highest in European countries. Retrospective analysis showed tha...

journal_title：Bulletin of experimental biology and medicine

authors： Smirnova TY,Pospekhova NI,Lyubchenko LN,Tjulandin SA,Gar'kavtseva RF,Ginter EK,Karpukhin AV

更新日期：2007-07-01 00:00:00

abstract：:We propose a noninvasive method of in vivo examination the hemostasis system based on speckle pattern analysis of coherent light scattering from the skin. We compared the results of measuring basic blood coagulation parameters by conventional invasive and noninvasive methods. A strict correlation was found between the...

journal_title：Bulletin of experimental biology and medicine

authors： Kuznik BI,Fine IW,Kaminsky AV

更新日期：2011-09-01 00:00:00