Abstract：
:Melatonin administered to intact animals increased glutathione concentration and activities of glutathione peroxidase, glutathione reductase, NADP-isocitrate dehydrogenase, and glucose-6-phosphate dehydrogenase in the liver. In animals with toxic hepatitis melatonin treatment decreased glutathione concentration and enzyme activities, which was probably associated with inhibition of free radical oxidation under the influence of this hormone.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Pashkov AN,Popov SS,Semenikhina AV,Rakhmanova TIdoi
10.1007/s10517-005-0346-7subject
Has Abstractpub_date
2005-05-01 00:00:00pages
565-8issue
5eissn
0007-4888issn
1573-8221pii
doijournal_volume
139pub_type
杂志文章abstract：:The role of JNK-mediated signal pathway and participation of p53 transcription factor in stimulation of mesenchymal precursor cell function by the fibroblast growth factor was studied. The levels of fibroblast colony- and cluster formation and proliferative activity of mesenchymal precursors increased in response to J...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-015-2997-3
更新日期：2015-08-01 00:00:00
abstract：:Nanocrystalline particles of chitin in the form of hydrosol in a concentration of 0.63 mg/ml have no effect on aggregation of human platelets and clotting time of platelet-poor plasma in coagulation tests. ADP-induced aggregation of human platelets was inhibited by these nanoparticles in concentrations of 0.63 and 1.0...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-018-4076-z
更新日期：2018-04-01 00:00:00
abstract：:Human recombinant erythropoietin adsorbed on poly(butyl)cyanoacrylate nanoparticles and administered intraperitoneally in a dose of 0.05 mg/kg exhibited a neuroprotective effect in experimental intracerebral posttraumatic hematomas (hemorrhagic stroke) and reduced animal mortality. Human recombinant erythropoietin, na...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-013-2123-3
更新日期：2013-06-01 00:00:00
abstract：:Structural changes in the brain of outbred mice were studied after infection with influenza A/H5N1 strain isolated in the Novosibirsk region. High mortality was observed after intranasal infection. Examination of brain specimens revealed vasculopathies with thrombosis of the microcirculatory vessels, pericellular and ...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-010-0845-z
更新日期：2009-12-01 00:00:00
abstract：:Circadian dynamics of rectal reactivity was studied in humans with regular and irregular rhythms of bowel evacuation function by chronoenterography. In individuals with regular rhythm of this function (stool 7 days per week) the acrophase of circadian rhythm of rectal reactivity was observed in morning hours, while in...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1023/a:1022965212971
更新日期：2002-12-01 00:00:00
abstract：:We studied a biomaterial for a new domestic product, a biological envelope for implantation of cardiac electronic devices. The product is designed to prevent complications after pacemaker implantation and to facilitate the reimplantation procedure. By chemical and biological processing of raw materials (submucosa of p...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-020-04712-0
更新日期：2020-01-01 00:00:00
abstract：:Comparative study of cultured human bone marrow and adipose tissue (lipoaspirate) mesenchymal stem cells was carried out. The main morphological parameters, proliferative activity, expression of surface and intracellular markers of these cells were characterized. Flow cytofluorometry and histological staining showed t...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-005-0430-z
更新日期：2005-07-01 00:00:00
abstract：:We studied sterility and toxicity of vaccine LS1 containing aberrant gangliosides isolated from brain bioptates of 48 patients with gliomas of different malignancy and covalently bound to keyhole limpet hemocyanin. The vaccine was safe. This preparation produced no side effects in experimental animals. Our findings su...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1023/a:1021908331236
更新日期：2002-10-01 00:00:00
abstract：:We developed wound coating based on natural biopolymer chitosan with additional components (ceruloplasmin, L-asparaginic acid, and glycerol). Experiments on albino male rats demonstrated its regeneratory, antioxidant, and antibacterial effects on wounds involving all layers of the skin. Due to chemical composition and...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-016-3258-9
更新日期：2016-03-01 00:00:00
abstract：:Preliminary injection of succinic semialdehyde into animals in experiments with hypoxia led to a lower concentration of free ammonia in their brain tissues than in control experiments in which the compound was not given. The enzyme system of the liver tissue catalyzes the oxidation of NAD-H-2 by succinic semialdeyde a...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/BF00799318
更新日期：1975-01-01 00:00:00
abstract：:We studied the effects of ionophores on activity of Na+,Cl-(HCO 3- )-ATPase. The most significant effect on the activity of this enzyme was produced by protonophore 2,4-dinitrophenol. The effect of this drug largely depended on the cation and anion composition and pH of the incubation medium and its pH. Activity of Na...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-016-3504-1
更新日期：2016-10-01 00:00:00
abstract：:We studied the effect of constant illumination for 1 month on female GC (genetic catalepsy) and Wistar rats (control). Light exposure decreased the degree of cataleptic freezing in female GC rats (compared to the control). Norepinephrine concentration in cataleptic rats returned to normal under these conditions: this ...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-008-0200-9
更新日期：2008-07-01 00:00:00
abstract：:We performed a comparative study of the localization, distribution, metabolic activity, and surface properties of human bone marrow mesenchymal stromal cells after static and perfusion seeding to macroporous alginate cryogels. A simple perfusion system for mesenchymal stromal cell seeding to macroporous alginate cryog...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-011-1185-3
更新日期：2011-02-01 00:00:00
abstract：:Acute experiments on anesthetized rabbits were performed to compare dilator responses of the carotid arteries in a wide range of blood flow rates. In males, the reactivity of vessels to changes in blood flow rate was higher than in females. Thirty percent of the revealed sex differences are due to various blood viscos...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/BF02439791
更新日期：2000-05-01 00:00:00
abstract：:The effects of opioids (morphine and fentanyl) on the function of mechanoreceptive respiration regulatory loop were demonstrated. In most opioid-treated rats (74% cases) vagotomy was followed by apneustic respiration with inspiration pause. Excess of opioids in rat CNS produced minor disturbances in the respiration rh...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-005-0301-7
更新日期：2005-04-01 00:00:00
abstract：:The content of MMP-8 and MMP-9 in oral fluid of 145 patients (95 women and 50 men, 18-52 years) was measured by enzyme immunoassay. We examined 63 subjects with the intact periodontium and 82 patients with chronic generalized periodontitis (25 patients with mild disease, 45 patients with moderate disease, and 12 patie...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-011-1498-2
更新日期：2011-12-01 00:00:00
abstract：:The author name G. A. Chastikina should read G. A. Chastikin. ...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章,已发布勘误
doi：10.1007/s10517-017-3883-y
更新日期：2017-09-01 00:00:00
abstract：:Measurements with extracellular microelectrode technique showed that depolarization of motor nerve terminals in frog cutaneous pectoris muscle with high-potassium solution (40 mM K(+)) increased frequency of miniature end-plate currents. Both fast intracellular calcium chelator BAPTA-AM and slow chelator EGTA-AM equal...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-009-0369-6
更新日期：2008-12-01 00:00:00
abstract：:Apoptosis markers (p53, PUMA, p21, and Mdm2) were studied in patients with rheumatoid arthritis at the early and late stages of disease on bone marrow smears and frozen sections of the articular synovial membrane. The target molecules were found in all patients. The early stage was characterized by maximum expression ...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-014-2353-z
更新日期：2014-01-01 00:00:00
abstract：:The effect of non-benzodiazepine anxiolytics on the ethanol-induced hyperlocomotion and behavioral sensitization was assessed in male DBA/2 mice. Selank that enhances activity of the endogenous opioid system (0.3 mg/kg, intraperitoneally), similar to the nonselective opiate receptor blocker naloxone (1.0 mg/kg, intrap...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-016-3544-6
更新日期：2016-11-01 00:00:00
abstract：:Study was performed by counting cells with chromosomal aberrations in C57Bl/6 mice. Bark dry extract was given perorally in doses of 50, 150, 450, and 1500 mg/kg. Mutagens dioxidine and cyclophosphamide were injected intraperitoneally in doses of 200 and 20 mg/kg, respectively. Bark dry extract in doses of 150 and 150...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-005-0074-z
更新日期：2004-11-01 00:00:00
abstract：:Loading of neutrophils with immune complexes changed their functional activity and intracellular pH. These changes depended on the size of immune complexes. UV irradiation of neutrophils loaded with immune complexes led to a molecular weight-dependent decrease in intracellular pH. After irradiation the chemiluminescen...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1023/a:1013174802845
更新日期：2001-09-01 00:00:00
abstract：:Angiogenic action of compound GK-2, a dimeric dipeptide mimetic of loop 4 of nerve growth factor (NGF), was studied in in vitro and in vivo experiments. Experiments on human endothelial cell culture HUVEC showed that compound GK-2 significantly (p<0.05) stimulated the initial stage of angiogenesis, and its angiogenic ...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-016-3450-y
更新日期：2016-08-01 00:00:00
abstract：:Using an integral qualitative and quantitative approach to the studies of initiation of the biological material crystallogenesis, we showed in experiments with normal human saliva that the external characteristics of biological fluid (pH, osmolality, and environmental temperature) determine the results of crystallizat...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-007-0118-7
更新日期：2007-03-01 00:00:00
abstract：:The resistance of native and circulating modified low-density lipoproteins from human blood to spontaneous and polyethylene glycol-induced association was studied by recording light transmission fluctuations. Circulating modified low-density lipoproteins were less resistant to association than native low-density lipop...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-005-0047-2
更新日期：2004-10-01 00:00:00
abstract：:We studied mesenchymal stem cells from human bone marrow, adipose tissue, skin, placenta, and thymus. Morphological study and cytofluorometrical analysis by the main marker genes (CD10, CD13, CD31, CD44, CD90, CD105) were carried out. Mesemchymal stem cells of the studied tissues during isolation and culturing were mo...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-005-0331-1
更新日期：2005-04-01 00:00:00
abstract：:Single intramuscular injection of selective of NMDA receptor blocker memantine in the maximum dose of 20 mg/kg prevented the development of acute generalized tonic-clonic kainate seizures in 60% rats, but did not alleviate clonic kainate seizures and prevented chronic kainate lethality in only 30% rats. Intramuscular ...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-014-2480-6
更新日期：2014-05-01 00:00:00
abstract：:We studied the relationship between the length and tension in isolated strips of the capsules of bovine mesenteric lymph nodes. The deformation-strain and radius-pressure relationships were established in the lymph node. The capsule possesses high distensibility, modulus of elasticity at optimal tension was 0.09×10(5)...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-011-1246-7
更新日期：2011-05-01 00:00:00
abstract：:We studied the effect of 10-week treatment with intranasal insulin (0.5 IU/day) on glucose tolerance, glucose utilization, lipid metabolism, functions of pancreatic β cells, and insulin system in the liver of rats with cafeteria diet-induced metabolic syndrome. The therapy reduced body weight and blood levels of insul...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-017-3762-6
更新日期：2017-06-01 00:00:00
abstract：:The number of CD3(+)CD56-HLA-G(+) cells in the peripheral blood of breast cancer patients was shown to increase by 2 times. Our results and published data suggest that the increase in the relative content of CD3(+)CD56-HLA-G(+) cells in the circulating blood in breast cancer contributes to tumor development due to sup...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-015-3038-y
更新日期：2015-09-01 00:00:00
