Structural changes in the brain of mice infected with influenza A/H5N1 virus.

abstract：:Rarely repeated episodes of 1-h immobilization in rats were accompanied by an increase in the content of molecular products of lipid peroxidation and decrease in the amount of oxidatively modified proteins. Monoamine oxidase B inhibitor deprenyl prevented the poststress activation of lipid peroxidation. ...

journal_title：Bulletin of experimental biology and medicine

authors： Tseilikman VE,Sinitsky AI,Poyarkov KA,Vojdaev EV

更新日期：2009-12-01 00:00:00

abstract：:The anti-ischemic effect of synthetic and pharmacologically tested anxiolytic afobazole (10 mg/kg intravenously) was studied on anesthetized rats with acute endocardial ischemia caused by isoproterenol infusion (20 mg/kg/min). A calcium antagonist verapamil (1 mg/kg intravenously) belonging to the group of phenyl alky...

journal_title：Bulletin of experimental biology and medicine

authors： Seredenin SB,Tsorin IB,Vititnova MB,Stolyaruk VN,Chichkanov GG,Kryzhanovskii SA

更新日期：2013-10-01 00:00:00

abstract：:The qualitative and quantitative differences in lipids composition were found in chromatin fractions differing by attachment to the nuclear matrix and transcriptional activity. During liver regeneration after partial hepatectomy Changes in the lipid spectrum of chromatin fractions in G1- and S-phases are associated wi...

journal_title：Bulletin of experimental biology and medicine

authors： Trofimov VA,Dudko AA

更新日期：2006-01-01 00:00:00

abstract：:We studied the effect of sodium hydrosulfite (NaHS), a donor of hydrogen sulfide (H2S), on spontaneous contractive activity of isolated preparations of rat stomach and jejunum under isometric conditions. NaHS in concentrations of 10-200 μM reduced the amplitude, tonic tension, and frequency of contractions of the prep...

journal_title：Bulletin of experimental biology and medicine

authors： Shafigullin MY,Zefirov RA,Sabirullina GI,Zefirov AL,Sitdikova GF

更新日期：2014-07-01 00:00:00

abstract：:We analyzed the dynamics of neuropathic pain development and changes in catalase and superoxide dismutase (SOD) activities in the brain, liver, and skeletal muscles of male Wistar rats with 1-month streptozotocin-induced diabetes mellitus. A decrease in mechanical nociceptive threshold was revealed that progressed dur...

journal_title：Bulletin of experimental biology and medicine

authors： Shipilov VN,Chistyakova OV,Trost AM

更新日期：2016-05-01 00:00:00

abstract：:Blood coagulation was enhanced and all factors (total, enzyme, and non-enzyme) of the fibrinolytic system were suppressed in rats in 60 min after forced swimming test. Argininecontaining tetrapeptide glyproline Arg-Pro-Gly-Pro administered prior to this test activated fibrinolysis and prevented hypercoagulation. Admin...

journal_title：Bulletin of experimental biology and medicine

authors： Grigor'eva ME,Lyapina LA

更新日期：2017-01-01 00:00:00

abstract：:During exacerbation of cytomegalovirus infection during pregnancy, cytomegalovirus proteins penetrate across the external membrane of placental villous syncytiotrophoblast and suppress activities of ATPase and Bcl-2 protein. Simultaneous increase in the content of annexin V and caspase 3 leads to structural disturbanc...

journal_title：Bulletin of experimental biology and medicine

authors： Lutsenko MT,Andrievskaya IA

更新日期：2016-01-01 00:00:00

abstract：:Treadmill training of spinalized rats creates conditions for early appearance of rhythmic locomotor movements of the hind limbs. Recovery of the movements was paralleled by an appropriate structural organization of neurons in the anterior horns of the distal compartment of the spinal cord. ...

journal_title：Bulletin of experimental biology and medicine

authors： Moshonkina TR,Gilerovich EG,Fedorova EA,Avelev VD,Gerasimenko YP,Otellin VA

更新日期：2004-08-01 00:00:00

abstract：:We studied the effect of terahertz radiation at NO frequencies 150.176-150.664 GHz on gaseous and electrolyte composition of the blood in albino rats during stress. Partial or complete recovery of the studied parameters of blood gases and electrolytes in stressed animals was observed after 15- and 30-min terahertz irr...

journal_title：Bulletin of experimental biology and medicine

authors： Kirichuk VF,Tsymbal AA

更新日期：2010-12-01 00:00:00

abstract：:The safety of combined administration of ultralow doses of antigens to endothelial NO synthase (impaza) and nitrates for the treatment of erectile dysfunction in CHD patients was evaluated in an open non-comparative clinical trial. The efficiency and safety of impaza and the possibility of its administration to patien...

journal_title：Bulletin of experimental biology and medicine

authors： Zhavbert ES,Kachanova MV,Tarasov SA,Dugina YL,Sergeeva SA,Dovgalevskii PY,Epshtein OI

更新日期：2009-08-01 00:00:00

abstract：:Angiogenic action of compound GK-2, a dimeric dipeptide mimetic of loop 4 of nerve growth factor (NGF), was studied in in vitro and in vivo experiments. Experiments on human endothelial cell culture HUVEC showed that compound GK-2 significantly (p<0.05) stimulated the initial stage of angiogenesis, and its angiogenic ...

journal_title：Bulletin of experimental biology and medicine

authors： Kryzhanovskii SA,Antipova TA,Tsorin IB,Pekeldina ES,Stolyaruk VN,Nikolaev SV,Sorokina AV,Gudasheva TA,Seredenin SB

更新日期：2016-08-01 00:00:00

abstract：:Non-clonal and clonal abnormal cells (hypodiploid, polyploid, and with chromosome aberrations) were detected by the G-method in the bone marrow and blood of the majority of patients with non-Hodgkin lymphomas before therapy. The manifestation of these abnormalities changed individually after treatment. The most incide...

journal_title：Bulletin of experimental biology and medicine

authors： Ankina MA,Zavitaeva TA,Panferova TA,Shakhtarina SV,Pavlov VV

更新日期：2007-02-01 00:00:00

abstract：:We studied the effect of simvastatin (24 mg/kg per os for 30 days) on DNA synthesis ((3)H-thymidine autoradiography) and free radical oxidation (chemiluminescent method) in the gastric mucosa of albino mice under normal conditions and in ulcerative process induced by single indometacin administration. Simvastatin trea...

journal_title：Bulletin of experimental biology and medicine

authors： Timoshin SS,Bragina VV,Lebedko OA,Sazonova EN,Zhivotova EY,Fleischman MY

更新日期：2012-01-01 00:00:00

abstract：:We studied properties of bacterial biofilms during long-term culturing. The biofilms were preserved for more than 90 days under the chosen conditions. At the same time, amounts of matrix and cells underwent periodic changes. The biomass of the biofilms decreased approximately every 7 days and then returned to the prev...

journal_title：Bulletin of experimental biology and medicine

authors： Tetz GV,Artemenko NK,Zaslavskaya NV,Tetz VV

更新日期：2013-08-01 00:00:00

abstract：:The immunolocalization of apoptotic factors in rat neocortex was studied on the model of permanent occlusion of the middle cerebral artery with administration of exogenous BDNF. We revealed heterogeneous distribution of pro- and anti-apoptotic factors in the stroke area and in the surrounding penumbra, where caspase-3...

journal_title：Bulletin of experimental biology and medicine

authors： Kalinichenko SG,Matveeva NY,Korobtsov AV

更新日期：2020-09-01 00:00:00

abstract：:Specific features of neurological deficit and changes in the cellular composition of tracheal lymphoid structures during the immediate stage (day 1) of hemorrhagic stroke were studied in rats with various behavioral parameters. Modeling of hemorrhage in the left caudate nucleus of the brain was followed by the develop...

journal_title：Bulletin of experimental biology and medicine

authors： Klyueva LV,Koplik EV,Vasyanina KA,Pertsov SS

更新日期：2019-04-01 00:00:00

abstract：:More than 70% malignant mammary tumors contain steroid hormone receptors; this suggests the possibility of hormone therapy in the majority of patients with breast cancer (BC). The main cause of inefficiency of hormone therapy in BC is hormone resistance (tumor resistance to hormonal cytostatics). Here we discuss the m...

journal_title：Bulletin of experimental biology and medicine

authors： Scherbakov AM,Krasil'nikov MA,Kushlinskii NE

更新日期：2013-07-01 00:00:00

abstract：:Intravenous infection of chicken with H5N1 avian influenza virus (strain A/Gs/Krasnoozerskoye/627/05) causes rapid lethal outcome. Pathomorphological study of bird viscera showed manifestations of disseminated intravascular coagulation syndrome, generalized inflammatory reaction, and wide-scale necrobiotic changes in ...

journal_title：Bulletin of experimental biology and medicine

authors： Shestopalova LV,Shkurupiy VA,Sharkova TV,Shestopalov AM

更新日期：2008-12-01 00:00:00

abstract：:The incidence of mutations in the BRCA1 and BRCA2 genes in the studied sampling of 74 patients with ovarian cancer was 19%. The incidence of mutations in the Russian sampling of patients, formed without consideration for the family history, is one of the highest in European countries. Retrospective analysis showed tha...

journal_title：Bulletin of experimental biology and medicine

authors： Smirnova TY,Pospekhova NI,Lyubchenko LN,Tjulandin SA,Gar'kavtseva RF,Ginter EK,Karpukhin AV

更新日期：2007-07-01 00:00:00

abstract：:We measured the content of ROS and malondialdehyde in cells of in vivo drug-resistant murine P388 leukemia strains. It was found that the strains did not differ by malondialdehyde concentration, but intracellular concentration of ROS in cells of the cyclophosphamide-resistant strain (P388/CP) was higher than in cells ...

journal_title：Bulletin of experimental biology and medicine

authors： Balakina AA,Raevskaya TA,Pavlov VS,Mumyatova VA,Goncharova SA,Terent'ev AA

更新日期：2020-06-01 00:00:00

abstract：:Acute experiments on cats showed that injection of catecholamines induced unidirectional shifts in right and left atrial pressure in 70% cases (these shifts were positive in one half of cats and negative in the other half). In 30% cases, the left and right atrial pressures changed in opposite direction: right atrial p...

journal_title：Bulletin of experimental biology and medicine

authors： Tkachenko BI,Evlakhov VI,Poyasov IZ

更新日期：2005-01-01 00:00:00

abstract：:The appearance of autoantibodies to neuronal proteins (S100, GFAP, MBP, and NGF) in rat serum was analyzed by ELISA on days 5, 10, 17, 25, and 32 after streptozotocin injection. Simultaneously, blood glucose and insulin autoantibodies were assayed. Serum glucose level increased on the next day after streptozotocin inj...

journal_title：Bulletin of experimental biology and medicine

authors： Lotosh NG,Savel'eva EK,Selishcheva AA,Savel'ev SV

更新日期：2013-05-01 00:00:00

abstract：:Morphofunctional evaluation of the effect of biological dressing with collagen-1 on healing of 3A degree burn wound in outbred and mutant Hr(hr)/Hr(hr)(hairless) mice was carried out by the histological method and optic radioautography. A pronounced stimulatory effect of the dressing on skin regeneration in mice was d...

journal_title：Bulletin of experimental biology and medicine

authors： Kolokolchikova EG,Zhirkova EA,Golovatenko-Abramov PK,Platonov ES,Botcharova VS,Khvatov VB

更新日期：2010-07-01 00:00:00

abstract：:Toxicity of different types of manganese nanoparticles against glioblastoma U-87MG and U-251 cells and normal human cells was studied using MTT test. The selectivity of the toxic effect of nanoparticles was evaluated as the ratio of 50% cytotoxic concentration (СС50) for human embryos fibroblasts (FECh-15) to their СС...

journal_title：Bulletin of experimental biology and medicine

authors： Razumov IA,Zav'yalov EL,Troitskii SY,Romashchenko AV,Petrovskii DV,Kuper KE,Moshkin MP

更新日期：2017-08-01 00:00:00

abstract：:We revealed a significant positive correlation between the concentrations of tissue VEGF and its receptor VEGFR2 in the primary tumor. The degree and direction of changes in the content of VEGF and VEGFR2 in cytosols of tumors from patients with locally spread breast cancer during the preoperation therapy depended on ...

journal_title：Bulletin of experimental biology and medicine

authors： Kim EA,Gershtein ES,Vysotskaya IV,Kushlinskii NE

更新日期：2008-02-01 00:00:00

abstract：:Telocytes, a new type of interstitial stem cells with long thin processes that form a three-dimensional network around cardiomyocytes, vessels, and nerve fibers were described in the myocardium of children with tetralogy of Fallot. Two types of morphologically different telocytes, spindle-shaped and rounded, were iden...

journal_title：Bulletin of experimental biology and medicine

authors： Sukhacheva TV,Nizyaeva NV,Samsonova MV,Chernyaev AL,Shchegolev AI,Serov RA

更新日期：2020-05-01 00:00:00

abstract：:We showed for the first time that prolactin stimulates the synthesis and release of immunomodulating cytokines and lymphocyte-activating factors (e.g., interleukin-1) by peritoneal macrophages. Prolactin abolished the stress-induced inhibition of proliferation of peripheral blood lymphocytes and increased cell sensiti...

journal_title：Bulletin of experimental biology and medicine

authors： Fomicheva EE,Nemirovich-Danchenko EA,Korneva EA

更新日期：2004-06-01 00:00:00

abstract：:Number and size of aggregated lymphoid nodules in the small intestine of mice exposed to radiation using a γ-irradiation unit GOBO-60 with 137Cs source were measured using the methods of visual microscopy and morphometry. Morphological status of the nodules was estimated on days 4, 28, 60, and 90 after the exposure. S...

journal_title：Bulletin of experimental biology and medicine

authors： Klochkova SV,Kvaratskheliya AG,Alekseeva NT,Nikityuk DB

更新日期：2017-12-01 00:00:00

abstract：:We studied the effect of subbacteriostatic azithromycin concentrations on the formation of microbial biofilms by Pseudomonas aeruginosa strains that caused implant-associated infection of large joints. Azithromycin in subinhibitory for planktonic cells concentrations 0.01-0.02 μg/ml stimulated biofilm formation by bot...

journal_title：Bulletin of experimental biology and medicine

authors： Babushkina IV,Ulyanov VY,Mamonova IA,Shpinyak SP

更新日期：2020-10-01 00:00:00

abstract：:Apoptosis of blood neutrophils from healthy donors was studied under conditions of cell culturing with different concentrations of H(2)O(2), selective NO synthase inhibitor, and inductor of NO synthesis (L-arginine). In vitro incubation of neutrophilic leukocytes with 5 mM H(2)O(2) led to activation of the apoptotic p...

journal_title：Bulletin of experimental biology and medicine

authors： Stepovaya YA,Zhavoronok TV,Starikov YV,Bychkov VA,Chasovskih NY,Starikova YG,Petina GV,Novitsky VV,Ryazantseva NV

更新日期：2008-12-01 00:00:00