Abstract：
:We studied the effect of simvastatin (24 mg/kg per os for 30 days) on DNA synthesis ((3)H-thymidine autoradiography) and free radical oxidation (chemiluminescent method) in the gastric mucosa of albino mice under normal conditions and in ulcerative process induced by single indometacin administration. Simvastatin treatment activated free radical oxidation, which was seen from enhanced chemiluminescence in the mucosa homogenate (by 1.7-4.6 times). Administration of indometacin against the background of simvastatin treatment potentiated local oxidative stress and inhibited DNA synthesis. Under these conditions, the area of ulcerative lesion in the gastric mucosa increased by 3.0 times.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Timoshin SS,Bragina VV,Lebedko OA,Sazonova EN,Zhivotova EY,Fleischman MYdoi
10.1007/s10517-012-1512-3subject
Has Abstractpub_date
2012-01-01 00:00:00pages
298-300issue
3eissn
0007-4888issn
1573-8221journal_volume
152pub_type
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