Effect of ACTH on pain sensitivity in rats.

abstract：:Olivomycin (DNA-binding antibiotic) in nanomolar concentrations induces apoptosis of human tumor cells and inhibits p53-dependent transcription of the reporter gene (basal and induced by antitumor drugs). Olivomycin aglycon induces no cytotoxicity and does not block transcription. ...

journal_title：Bulletin of experimental biology and medicine

authors： Simonova VS,Samusenko AV,Filippova NA,Tevyashova AN,Lyniv LS,Kulik GI,Chekhun VF,Shtil AA

更新日期：2005-04-01 00:00:00

abstract：:Oxygen-dependent processes in peripheral blood monocytes were intensified in patients with metabolic cardiovascular syndrome. This was manifested in increased production of O(2)(*-) and NO. Among metabolic factors (cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triacylglycerols...

journal_title：Bulletin of experimental biology and medicine

authors： Suslova TE,Gruzdeva OV,Fedorova TS,Karpov RS

更新日期：2004-05-01 00:00:00

abstract：:We studied the effect of sodium hydrosulfite (NaHS), a donor of hydrogen sulfide (H2S), on spontaneous contractive activity of isolated preparations of rat stomach and jejunum under isometric conditions. NaHS in concentrations of 10-200 μM reduced the amplitude, tonic tension, and frequency of contractions of the prep...

journal_title：Bulletin of experimental biology and medicine

authors： Shafigullin MY,Zefirov RA,Sabirullina GI,Zefirov AL,Sitdikova GF

更新日期：2014-07-01 00:00:00

abstract：:The rate and strength of heart contractions decreased after 10-min perfusion of rat myocardium with Krebs-Henseleit solution containing a selective cannabinoid receptor agonist HU-210 in a final concentration of 10 nM. HU-210 completely blocked the positive inotropic and chronotropic effect of beta-adrenoceptor agonis...

journal_title：Bulletin of experimental biology and medicine

authors： Maslov LN,Lasukova OV,Krylatov AV,Uzhachenko RV,Pertwee R

更新日期：2004-12-01 00:00:00

abstract：:We studied in vitro cytostatic effect of doxorubicin on bone marrow cells preincubated with NAD and reduced glutathione. The presence of NAD and glutathione in the medium potentiated membrane toxicity of this antibiotic, but prevented its toxic effects on intracellular pool of pyridine nucleotides during oxidative str...

journal_title：Bulletin of experimental biology and medicine

authors： Egorova AB,Uspenskaya YA,Nefedov VP

更新日期：2001-07-01 00:00:00

abstract：:Daily (for 3 days) 1-hour immobilizations were followed by an increase in protein oxidative modification and leukocyte infiltration in the liver, and a decrease in monoamine oxidase B activity. Receptor antagonist of glucocorticoids RU38486 limited the stress-induced increase in protein carbonylation and decrease in m...

journal_title：Bulletin of experimental biology and medicine

authors： Tseilikman VE,Ryabinin VE,Tseilikman OB,Sinitskii AI,Deev RV

更新日期：2013-11-01 00:00:00

abstract：:The content of urokinase- and tissue-type plasminogen activators and plasminogen activator inhibitor PAI-1 in the cytosol of primary and metastatic melanomas and benign skin pigment neoplasms was estimated by enzyme immunoassay. It was shown that local growth and invasion of melanomas are related to suppressed express...

journal_title：Bulletin of experimental biology and medicine

authors： Gershtein ES,Medvedeva SV,Babkina IV,Kushlinskii NE,Trapeznikov NN

更新日期：2001-07-01 00:00:00

abstract：:The antiamnestic effects of tenoten (pediatric formulation) was demonstrated on the model of scopolamine-induced amnesia of passive avoidance reflex and the nootropic effect of this preparation was demonstrated on the model of incomplete conditioning and in rat pups with experimental attention deficit syndrome. The ef...

journal_title：Bulletin of experimental biology and medicine

authors： Voronina TA,Molodavkin GM,Borodavkina MV,Kheyfets IA,Dugina YL,Sergeeva SA

更新日期：2009-09-01 00:00:00

abstract：:We studied the involvement of protein kinase Mζ (PKMζ) in the mechanisms of amnesia development within 10 days after disruption of conditioned food aversion memory with ZIP (a PKMζ inhibitor). Repeated training performed in 3 days after amnesia induction with ZIP, led to the formation of conditioned food aversion memo...

journal_title：Bulletin of experimental biology and medicine

authors： Nikitin VP,Solntseva SV,Kozyrev SA

更新日期：2019-10-01 00:00:00

abstract：:Formulas for calculation of the section non-perpendicularity error in estimation of the perimeter and cross-sectional area of microvessel profiles are proposed for the two-dimensional isotropic approximation. A relationship was established between the bias and random error associated with non-perpendicularity correspo...

journal_title：Bulletin of experimental biology and medicine

authors： Krasnoperov RA,Grachev SV,Gerasimov AN

更新日期：2000-10-01 00:00:00

abstract：:Ultrastructural characteristics of cell populations in the gastric tube mucosa were studied after plastic surgery for benign esophageal disease. The foveolar epithelium mainly consisted of secretory active mucocytes with small changes in cytoplasmic organelles. Functionally immature parietal cells and gland cells in t...

journal_title：Bulletin of experimental biology and medicine

authors： Lapii GA,Nepomnyashchikh LM,Sudovykh IE,Kutepov AV,Govorkov RV

更新日期：2011-02-01 00:00:00

abstract：:Levosimendan is effective in the therapy of chronic heart failure in both mature and old rats, but the duration of its therapeutic effect differs in these age groups. In 15 days after treatment, the myocardium in old rats maintained augmented functionality, whereas in old animals, functional potencies returned to the ...

journal_title：Bulletin of experimental biology and medicine

authors： Mamalyga ML,Mamalyga LM

更新日期：2020-05-01 00:00:00

abstract：:Morphological study of allotransplants of rat embryonic neocortex 14-18 months after transplantation into the neocortex, lateral cerebral ventricle, and sciatic nerve of adult animals revealed death of nerve and glial cells in the delayed postoperation period independently on the site of transplantation. After heterot...

journal_title：Bulletin of experimental biology and medicine

authors： Petrova ES,Otellin VA

更新日期：2003-09-01 00:00:00

abstract：:cDNA encoding VEGF and Ig-like extracellular domains 2-4 of VEGFR-1 (sFlt-1(2-4)) were cloned into prokaryotic expression vectors pET32a and pQE60. Recombinant proteins were purified (metal affinity chromatography) and renatured. Chemiluminescent study for the interaction of recombinant VEGF and sFlt-1(2-4) showed tha...

journal_title：Bulletin of experimental biology and medicine

authors： Leopol'd AV,Baklaushev VP,Korchagina AA,Shein SA,Grinenko NF,Pavlov KA,Ryabukhin IA,Chekhonin VP

更新日期：2012-04-01 00:00:00

abstract：:Stimulation of lymph circulation and microcirculation and increase in contractile activity of the wall and cusps of valves in lymphatic microvessels are the mechanisms for a therapeutic effect of dimephosphon. These changes improve resorption and transport of tissue and cell metabolites from the interstitial space. ...

journal_title：Bulletin of experimental biology and medicine

authors： Khafiz'yanova RKh,Mukhutdinov DA

更新日期：2005-06-01 00:00:00

abstract：:Brain pathology (acute hypoxia and posthypoxic encephalopathy) is associated with less pronounced hyperplasia of the bone marrow erythroid stem (due to decreased count of proliferating committed precursors) and hemolytic anemia, while secretory activity of stromal cells of the hemopoiesis-inducing microenvironment is ...

journal_title：Bulletin of experimental biology and medicine

authors： Gol'dberg ED,Dygai AM,Zyuz'kov GN,Gur'yantseva LA,Suslov NI

更新日期：2002-08-01 00:00:00

abstract：:Morphological signs of early interstitial fibrosis, developing under conditions of acute viral inflammation (postinfection days 1-14), were observed in C57Bl/6 mice infected with influenza A/H5N1 A/goose/Krasnoozerskoye/627/05 virus. The development of fibrosis was confirmed by an increase in the number of lung cells ...

journal_title：Bulletin of experimental biology and medicine

authors： Anikina AG,Shkurupii VA,Potapova OV,Kovner AV,Shestopalov AM

更新日期：2014-04-01 00:00:00

abstract：:Phosphatidylcholine liposomes in a dose of 25 mg/kg displayed wound-healing properties. They increased the count of alveolar macrophages, lymphocytes, and microvessels in damaged regions and, therefore, attenuated emphysematous changes in the lungs. ...

journal_title：Bulletin of experimental biology and medicine

authors： Kornilova ZK,Selishcheva AA,Perel'man MI

更新日期：2001-02-01 00:00:00

abstract：:We studied the effects of stress exposure during the adolescent period of development (SAPD) on the parameters of inflammatory painful response and the level of depression-like behavior in prenatally stressed adult male rats. In addition, we analyzed the effects of selective serotonin (5-HT) reuptake inhibitor fluoxet...

journal_title：Bulletin of experimental biology and medicine

authors： Butkevich IP,Mikhailenko VA

更新日期：2020-07-01 00:00:00

abstract：:Electron microscopic study of changes in cultured cells caused by Vibrio cholerae recombinant hemagglutinin/protease (HA/P) showed significant structural changes, most pronounced in HeLa and L-929 cells not forming a compact monolayer with tight junctions between the cells: formation of numerous vesicles on the cell s...

journal_title：Bulletin of experimental biology and medicine

authors： Sayamov SR,Monakhova EV,Fedorenko GM,Tkacheva TI,Markina OV,Alekseeva LP,Pisanov RV,Bardakhchian EA

更新日期：2012-02-01 00:00:00

abstract：:We studied electrophysiological parameters and morphological changes in the adrenal glands and spleen of CBA mice feeding a low-choline diet and/or ethanol-containing diet. The polarization coefficient underwent similar changes in the adrenal glands and spleen, which was associated with different contribution of imped...

journal_title：Bulletin of experimental biology and medicine

authors： Tornuev YV,Nepomnyashchikh LM,Koldysheva EV

更新日期：2005-11-01 00:00:00

abstract：:The linear parameters and number of Langerhans islets were evaluated in rats with alloxaninduced diabetes mellitus after transplantation of fetal pancreatic tissue to the anterior chamber of the eye. The islets significantly increased in size by week 3 after surgery and a trend to an increase in their number was obser...

journal_title：Bulletin of experimental biology and medicine

authors： Kulikov DA,Kulikov AV,Arkhipova LV,Smirnova GN,Dreval' AV,Tikhonova LP,Gaivoronskii IV,Sukhikh GT

更新日期：2015-01-01 00:00:00

abstract：:Over many years, tick-borne infections remain one of the most serious threats to human health worldwide. The immune response to these infections in a human after confirmed bite by an infected carrier at the early stages of infection in the absence of clinical symptoms can be the first indicator of the presence of the ...

journal_title：Bulletin of experimental biology and medicine

authors： Danchinova GA,Khasnatinov MA,Lyapunova NA,Solovarov IS,Manzarova EL,Lyapunov AV,Petrova IV

更新日期：2019-03-01 00:00:00

abstract：:We studied the effects and mechanisms of action of NaHS, an H2S donor, on isolated phenylephrine-precontracted bovine mesenteric lymph nodes. NaHS induced concentration-dependent relaxation of lymph nodes. Removal of the endothelium reduced, but did not abolish the relaxing effect of NaHS. The relaxing effect was redu...

journal_title：Bulletin of experimental biology and medicine

authors： Lobov GI

更新日期：2020-06-01 00:00:00

abstract：:Blood flow in reproductive organs was studied during experimental cessation of blood outflow in the testicular vein. This pathological state was accompanied by disturbances of the complex pathogenesis. The major component was autoregulatory focal ischemia, which resulted from the venoarterial response to venous hypert...

journal_title：Bulletin of experimental biology and medicine

authors： Artifeksov SB,Artyukhin AA

更新日期：2007-06-01 00:00:00

abstract：:NAD, cytochrome c, and energostim modulated the fluorescence emission spectrum of trifluoperazine in the solution and in microsomal suspension. The data suggest that NAD and energostim modify structural and conformational characteristics of the dopamine receptor-trifluoperazine complex. These changes probably underlie...

journal_title：Bulletin of experimental biology and medicine

authors： Chikobava EA,Galenko-Yaroshevskii PA,Gurskaya EV,Mamuchishvili IG,Sukoyan GV

更新日期：2004-03-01 00:00:00

abstract：:The concentrations of vascular endothelial growth factor and endothelin in the placenta progressively increased during normal pregnancy. Production of vascular endothelial growth factor and endothelin in the placenta exceeded the normal during trimester I miscarriage and trimester III premature birth accompanied by in...

journal_title：Bulletin of experimental biology and medicine

authors： Krukier II,Pogorelova TN

更新日期：2006-02-01 00:00:00

abstract：:Activities of antioxidant enzymes, vitamin E level, lactate dehydrogenase isoenzyme spectrum, and effects of melatonin on these parameters were studied in the myocardium of rats aged 6, 12, 18, and 24 months exposed to different illumination regimens. The greatest number of changes was recorded in rats exposed to perm...

journal_title：Bulletin of experimental biology and medicine

authors： Khizhkin EA,Ilukha VA,Ilyina TN,Unzhakov AR,Vinogradova IA,Anisimov VN

更新日期：2010-09-01 00:00:00

abstract：:A test system developed by the authors was used to measure serum concentrations of soluble Fas in patients with malignant and benign tumors of different location and morphology. Relationships between soluble Fas levels and the main clinical and morphological characteristics of cancer were evaluated. It is proven that ...

journal_title：Bulletin of experimental biology and medicine

authors： Abbasova SG,Vysotskii MM,Ovchinnikova LK,Obusheva MN,Digaeva MA,Britvin TA,Bahoeva KA,Karabekova ZK,Kazantzeva IA,Mamedov UR,Manuchin IB,Davidov MI

更新日期：2009-10-01 00:00:00

abstract：:Fluorescent granular cells of the thymus lobule containing neurotransmitter monoamines express Ia antigen and S-100 protein, which attests to their macrophage origin; positive staining with aldehyde fuchsin points to secretion of peptide hormones by these cells. These facts and the absence of phagocytic activity allow...

journal_title：Bulletin of experimental biology and medicine

authors： Gordon DS,Sergeeva VE,Smorodchenko AT,Kirillov NA,Petrova TL,Olangin OI,Spirin IV

更新日期：2001-07-01 00:00:00