Abstract：
:Ready dosage form (eye drops) prepared on the basis of recombinant alpha2-IFN exhibits high activity towards herpes simplex type 1 virus in vitro. Systematic study of the antiherpesvirus effect of this drug in combination with modified nucleosides showed an inhibitory effect of the synergic type. Combination of IFN preparation with some nucleosides, including ribavirin, proved to be highly effective towards drug-resistant herpes virus.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Vyzhlova EN,Andronova VL,Galegov GA,Malinovskaya VVdoi
10.1007/s10517-006-0263-4subject
Has Abstractpub_date
2006-06-01 00:00:00pages
724-6issue
6eissn
0007-4888issn
1573-8221pii
doijournal_volume
141pub_type
杂志文章abstract：:For evaluation of the spatial structure of chromatin in nuclei of mesenchymal SC we determined the position of centromeres and individual chromosomes in interphase nucleus of mesenchymal SC. More than 300 nuclei in 7 cultures of mesenchymal SC were analyzed. Centromeres of chromosomes 6, 8, and 11 lie at a longer (0.6...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-011-1370-4
更新日期：2011-08-01 00:00:00
abstract：:In patients with ovarian cancer, the colony-forming capacity and radiosensitivity of clonogenic tumor cells from the primary node and metastases (ascites) differed considerably. ...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1023/a:1012362804949
更新日期：2001-06-01 00:00:00
abstract：:The stimulatory effect of a local focus of granulation tissue, created in the bone marrow cavity, on reparative osteogenesis after tibial bone fracture was detected in experimental rats by microscopic examination of histological sections, scanning electron microscopy, and X-ray electron probe microanalysis. ...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-014-2503-3
更新日期：2014-05-01 00:00:00
abstract：:The influence of a new 2-mercaptobenzimidazole derivative afobazole on cytogenetic effects of dioxidine and cyclophosphamide was studied by counting chromosome aberrations in bone marrow cells of C57Bl/6 mice. Afobazole (1-100 mg/kg perorally) exhibited antimutagenic activity determined by its antioxidant properties. ...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：
更新日期：2000-11-01 00:00:00
abstract：:We studied the effect of simvastatin (24 mg/kg per os for 30 days) on DNA synthesis ((3)H-thymidine autoradiography) and free radical oxidation (chemiluminescent method) in the gastric mucosa of albino mice under normal conditions and in ulcerative process induced by single indometacin administration. Simvastatin trea...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-012-1512-3
更新日期：2012-01-01 00:00:00
abstract：:Experiments on "stationary aging" cultures of B11dii-FAF28 Chinese hamster cells showed that contact inhibition of cell growth and further culturing of cells in the stationary phase led to continuous inhibition of enzymes realizing poly-ADP-ribosylation of chromatin proteins. Cell density in the monolayer and percenta...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-006-0238-5
更新日期：2006-05-01 00:00:00
abstract：:The effects of intranasal pretreatment with antibodies against glutamate on focal penicillin-induced epileptic activity were studied by recording electrocorticogram in non-anesthetized freely moving male Wistar rats. Anticonvulsant effects of intranasal administration of anti-glutamate antibodies (300 μg/kg) 1 h befor...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-013-2206-1
更新日期：2013-09-01 00:00:00
abstract：:We studied the effect of experimental liver injury of various origins (toxic, autoimmune, alcoholic, and mesenchymal) in the females on motility of spermatozoa in the offspring. The number of infertile (jerking and immotile) spermatozoa increased, whereas the number of fertile spermatozoa (progressive motile and slow ...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-014-2683-x
更新日期：2014-11-01 00:00:00
abstract：:We proposed a new indicator for evaluation of functional activity of Ca(2+) in human blood serum based on lysis of sheep erythrocytes with 10% human blood serum in the presence of 0.55 mM ethylene glycol tetraacetic acid at 37°C for 10 min. After incubation, the degree of sheep erythrocytes lysis inhibition is estimat...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-015-2948-z
更新日期：2015-07-01 00:00:00
abstract：:Brain-derived neurotrophic factor (BDNF) plays the central role in the mechanisms of regulation of neurogenesis and neuroplasticity. Impairment of these mechanisms is considered as one of the main etiological factors of depression. Dimeric dipeptide mimetic of BDNF loop 4 bis-(N-monosuccinyl-l-seryl-l-lysine) hexameth...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-017-3638-9
更新日期：2017-02-01 00:00:00
abstract：:The safety of combined administration of ultralow doses of antigens to endothelial NO synthase (impaza) and nitrates for the treatment of erectile dysfunction in CHD patients was evaluated in an open non-comparative clinical trial. The efficiency and safety of impaza and the possibility of its administration to patien...
journal_title：Bulletin of experimental biology and medicine
pub_type： 临床试验,杂志文章
doi：10.1007/s10517-009-0688-7
更新日期：2009-08-01 00:00:00
abstract：:The effect of non-benzodiazepine anxiolytics on the ethanol-induced hyperlocomotion and behavioral sensitization was assessed in male DBA/2 mice. Selank that enhances activity of the endogenous opioid system (0.3 mg/kg, intraperitoneally), similar to the nonselective opiate receptor blocker naloxone (1.0 mg/kg, intrap...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-016-3544-6
更新日期：2016-11-01 00:00:00
abstract：:Serum activity of tartrate-resistant acid phosphatase 5b (TRAP 5b) in patients with breast cancer and prostate cancer having bone metastases was much higher than in healthy donors and patients without skeletal injuries. TRAP 5b activity in patients with breast cancer and multiple bone metastases surpassed that in pati...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1023/b:bebm.0000046945.95479.d6
更新日期：2004-07-01 00:00:00
abstract：:The author name M. V. Edeeva should read M. V. Edeleva. ...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章,已发布勘误
doi：10.1007/s10517-018-4123-9
更新日期：2018-05-01 00:00:00
abstract：:We studied the impact of acute glycerol-induced renal failure on blood levels and daily urinary excretion of arginine, monomethylarginine, and asymmetric and symmetric dimethylarginine. Acute renal failure was accompanied by enhanced daily excretion of asymmetric and symmetric dimethylarginine, increased plasma level ...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-012-1736-2
更新日期：2012-08-01 00:00:00
abstract：:We studied the role of carbon monoxide (CO) in the effect of P2X and P2Y receptor agonist ATP on the tone of rat aorta segments with intact endothelium. ATP (1-1000 μM) and P2X receptor agonist α,β-MeATP (100 μM) relaxed segments precontracted with phenylephrine (10 μM), while UTP (100-1000 μM) increased the amplitude...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-019-04527-8
更新日期：2019-07-01 00:00:00
abstract：:We studied the effects of potentiated antibodies to morphine and mu-opioid receptors on animal behavior in the forced swimming test and reaction of light avoidance after morphine withdrawal. Antibodies to morphine normalized behavioral characteristics in the forced swimming test, while antibodies to mu-opioid receptor...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1023/a:1024754007698
更新日期：2003-01-01 00:00:00
abstract：:We studied the neuroprotective effect of a new selective anxiolytic afobazole on rats with bilateral focal ischemic stroke in the prefrontal cortex caused by photothrombosis. Intraperitoneal injection of 5 mg/kg afobazole 1 h after surgery and over the next 8 days (daily treatment) produced a neuroprotective effect. A...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-008-0051-4
更新日期：2008-02-01 00:00:00
abstract：:We studied expression of Flt-1 and Flk-1 receptors on tumor cells obtained from 83 patients with locally advanced breast cancer after neoadjuvant chemotherapy. The mean period of observations was 32.3 months. The median recurrence-free survival periods for Flt-1(+) and Flt-1(-) patients were 55 and 32 months, respecti...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1023/a:1024975627843
更新日期：2003-05-01 00:00:00
abstract：:Exposure of rats with experimental diabetes mellitus to wide-band electromagnetic radiation generated by He-Ne laser and modulated by the pancreas and spleen is informing and phenomenological method prolonging animal life span, normalizing blood glucose level, and promoting regeneration of the pancreas. ...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-007-0049-3
更新日期：2007-02-01 00:00:00
abstract：:We studied ultrastructure of nuclear compartment in cardiomyocytes during regenerative and plastic insufficiency of the myocardium induced by anthracycline antibiotic daunomycin. A peculiarity of ultrastructural organization of cardiomyocyte nuclei under these conditions is almost complete disappearance of the heteroc...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：
更新日期：2000-12-01 00:00:00
abstract：:A combination of electrochemical lysis and photodynamic therapy were used to attain complete resorption of M-1 sarcoma in rats; both treatment modalities were used with minimum parameters. Fotolon served as the photosensitizer for photodynamic therapy. Accumulation of the sensitizer in the tumor and normal tissue was ...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-009-0439-9
更新日期：2009-01-01 00:00:00
abstract：:The effects of LPS from E. coli on DNA-binding activities of PPARα and PPARγ in the liver and immune system parameters of were studied in hypertensive ISIAH rats and normotensive WAG rats. In ISIAH rats characterized by low basal level of PPARα, PPARγ, and HDL, the response of the peripheral immune system compartment ...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-013-2167-4
更新日期：2013-08-01 00:00:00
abstract：:We studied the effect of turmeric extract in the composition of rectal suppositories on the level of LPO products and oxidative modification of proteins in the colon mucosa of Wistar rats with experimental Crohn's disease modeled by rectal administration of trinitrobenzenesulfonic acid. The suppositories containing tu...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-020-04883-w
更新日期：2020-07-01 00:00:00
abstract：:A new phenomenon (or paradox) consisting in higher statistical stability of samples, for example, tremorograms, in a group of different subjects than in the same subject in unchanged homeostasis. At the same time, it turns out that 15 different subjects are more similar (statistically) to each other than one person to...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-019-04540-x
更新日期：2019-08-01 00:00:00
abstract：:The incidence of 5 polymorphisms of N-acetyltransferase-2 gene was evaluated in patients with lung cancer. A803G polymorphism is a factor of lung cancer resistance in tobacco smoking Caucasians in Novosibirsk. Opposite effects of NAT2 gene polymorphisms on the risk of lung cancer are possible. ...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-007-0023-0
更新日期：2007-01-01 00:00:00
abstract：:Isolation and identification of rat brain protein regulated by serotonin-modulated protein SMP-69 is described. Intracerebral administration of anti-SMP-69 antibodies activates cerebral cortex cell genome and increases the content of electropheretic fraction 28. Intracerebral administration of isolated and purified pr...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/BF02766081
更新日期：2000-08-01 00:00:00
abstract：:The effect of low dose dichlorodiphenyltrichloroethane (DDT), omnipresent ecotoxicant and endocrine disruptor, on the functioning of the endocrine system is an urgent problem. We studied the effect of low dose DDT on thyroid status in rats. Rats receiving DDT in a dose of 1.890±0.086 μg/kg for 6 weeks showed increased...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-014-2443-y
更新日期：2014-04-01 00:00:00
abstract：:Changes in heart rate and stroke volume after successive blockade of cardiac adreno- and cholinoceptors were examined on rats of different age. It was established that irrespective of animal age the heart rate remained unchanged under conditions of total adreno- and cholinergic blockade of the heart. Stroke volume und...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-006-0278-x
更新日期：2006-07-01 00:00:00
abstract：:The hydruric response to water load in Wistar rats and homozygous Brattleboro rats with a hereditary defect in the synthesis of vasopressin was studied under conditions of increased brain serotonin level. Serotonin prevented the reduction in reabsorption of osmotically free water in normal rats, but had no effect in v...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-006-0121-4
更新日期：2006-02-01 00:00:00
