Effects of central endothelin-1 in normotensive and spontaneously hypertensive rats.

abstract：:Changes in the diurnal light cycle affect the morphofunctional state of the pineal gland. The volume of the nucleus, Golgi apparatus, and mitochondria in pinealocytes decreases after 45-day exposure to bright light. After 90 days, the degree of nuclear polymorphism increased, the specific volume of the Golgi apparatus...

journal_title：Bulletin of experimental biology and medicine

authors： Gerasimov AV,Logvinov SV,Kostyuchenko VP

更新日期：2010-12-01 00:00:00

abstract：:We studied the possibility of evaluation of the intensity of pathological oxidative processes in rat liver using an integral bioluminescent test with controlled perfusion of the isolated organ. The test revealed a significant correlation between the level of TBA-reactive products and bioluminescence intensity. ...

journal_title：Bulletin of experimental biology and medicine

authors： Remmel' NN,Kratasyuk VA,Maznyak OM,Inzhevatkin EV,Nefedov VP

更新日期：2003-01-01 00:00:00

abstract：:We studied the effect of 20 standard L-amino acids on proliferation of the nervous, cardiovascular, urogenital, digestive, and immune system tissues from young and old animals in organotypic cultures. The effect of amino acids on tissue culture proliferation depended on their origin and animal age. ...

journal_title：Bulletin of experimental biology and medicine

authors： Chalisova NI,Kontsevaya NE,Linkova NS,Pronyaeva VE,Chervyakova NA,Umnov RS,Benberin VV,Khavinson VH

更新日期：2013-08-01 00:00:00

abstract：:We studied the effects of ionophores on activity of Na+,Cl-(HCO 3- )-ATPase. The most significant effect on the activity of this enzyme was produced by protonophore 2,4-dinitrophenol. The effect of this drug largely depended on the cation and anion composition and pH of the incubation medium and its pH. Activity of Na...

journal_title：Bulletin of experimental biology and medicine

authors： Yurkiv VA,Melikhov VI,Shubin VS

更新日期：2016-10-01 00:00:00

abstract：:Prostatotropic activity of (3,5-dimethyl-4-hydroxy)benzyl thiododecane (T-DD) was evaluated on a model of benign prostatic hyperplasia induced in Wistar rats by chronic (2 months) intraperitoneal administration of sulpiride (40 mg/kg). Morphometric analysis of the dorsolateral lobe of the prostate showed that after th...

journal_title：Bulletin of experimental biology and medicine

authors： Nizomov SA,Sorokina IV,Zhukova NA,Tolstikova TG,Semenov DE,Prosenko AE

更新日期：2019-10-01 00:00:00

abstract：:The interaction between dopamine D1 and D2 receptors plays a role in immunomodulation. The results of thus interaction depends on the degree of receptor activation with selective agonists in different doses. Combined treatment with agonists of D1 and D2 receptors in high doses had a synergistic effect in the mechanism...

journal_title：Bulletin of experimental biology and medicine

authors： Devoino LV,Al'perina EL,Gevorgyan MM,Cheido MA

更新日期：2006-05-01 00:00:00

abstract：:Fluorescent granular cells of the thymus lobule containing neurotransmitter monoamines express Ia antigen and S-100 protein, which attests to their macrophage origin; positive staining with aldehyde fuchsin points to secretion of peptide hormones by these cells. These facts and the absence of phagocytic activity allow...

journal_title：Bulletin of experimental biology and medicine

authors： Gordon DS,Sergeeva VE,Smorodchenko AT,Kirillov NA,Petrova TL,Olangin OI,Spirin IV

更新日期：2001-07-01 00:00:00

abstract：:We studied secretory activity of adrenal zona fasciculata cells in pubertal rats exposed to low doses of endocrine disrupter DDT during prenatal and postnatal periods and only during postnatal period. In exposed animals, circulatory disturbances leading to degeneration and necrosis of cells as well as regeneration foc...

journal_title：Bulletin of experimental biology and medicine

authors： Yaglova NV,Tsomartova DA,Obernikhin SS,Nazimova SV,Yaglov VV

更新日期：2018-12-01 00:00:00

abstract：:We studied the relationship between the length and tension in isolated strips of the capsules of bovine mesenteric lymph nodes. The deformation-strain and radius-pressure relationships were established in the lymph node. The capsule possesses high distensibility, modulus of elasticity at optimal tension was 0.09×10(5)...

journal_title：Bulletin of experimental biology and medicine

authors： Lobov GI,Pan'kova MN

更新日期：2011-05-01 00:00:00

abstract：:Macrophage activity was studied after treatment with hybrid molecules obtained by condensation of terpenic acid residues (betulinic and betulonic acids) and α-tocopherol analogues (α-tocopherol hemisuccinate and Trolox acid). As distinct from betulinic acid and α-tocopherol hemisuccinate, hybrid molecules did not exhi...

journal_title：Bulletin of experimental biology and medicine

authors： Ivanova AN,Belsky YP,Spivak AY,Danilets MG,Belska NV,Chalitova RR,Ligatcheva AA,Uchasova EG

更新日期：2011-10-01 00:00:00

abstract：:Leprosy was modeled in an experiment on BALB/c, BALB/cNude, CBA, and C57BL/6ТNF-/- mice using three Mycobacterium leprae strains obtained from patients with a diagnosis of A30 according to ICD-10 from different regions of the Russian Federation. Proliferation of M. leprae of the used strains showed a temporal-quantita...

journal_title：Bulletin of experimental biology and medicine

authors： Karamova AE,Semenova VG,Verbenko DA,Obraztsova OA,Vanchugova KM,Nikonorov AA,Deryabin DG,Solomka VS,Kubanov AA

更新日期：2020-10-01 00:00:00

abstract：:We studied the effects of lithium carbonate on the cell cycle, apoptosis, and autophagy in hepatocellular carcinoma-29 cells (HCC-29) in vitro. Flow cytofluorometry analysis revealed accumulation of G2/M-phase HCC-29 cells and increase in the number of apoptotic cells in 48 h after administration of 5 mM lithium carbo...

journal_title：Bulletin of experimental biology and medicine

authors： Taskaeva YS,Bgatova NP,Dossymbekova RS,Solovieva AO,Miroshnichenko SM,Sharipov KO,Tungushbaeva ZB

更新日期：2020-12-01 00:00:00

abstract：:We performed a comparative analysis of biological activity of Lys-Glu peptide and its amino acid constituents. It was established that Lys-Glu stimulated proliferation of splenic cells in organotypic culture, while the mixture of glutamic acid and lysine inhibited culture growth. Using the method of molecular docking,...

journal_title：Bulletin of experimental biology and medicine

authors： Khavinson VKh,Tarnovskaya SI,Lin'kova NS,Chervyakova NA,Nichik TE,Elashkina EV,Chalisova NI

更新日期：2015-02-01 00:00:00

abstract：:Anaferon (pediatric formulation) administered in the therapeutic-and-prophylactic regimen to mice receiving intranasally 100% infecting dose of A/California/07/2009(H1N1)v influenza virus exhibited an antiviral effect and 10-fold reduced the production of influenza virus in the lungs of infected mice on days 4, 6, and...

journal_title：Bulletin of experimental biology and medicine

authors： Shishkina LN,Skarnovich MO,Kabanov AS,Sergeev AA,Olkin SE,Tarasov SA,Belopolskaya MV,Sergeeva SA,Epstein OI,Malkova EM,Stavsky EA,Drozdov IG

更新日期：2010-10-01 00:00:00

abstract：:Single intramuscular injection of selective of NMDA receptor blocker memantine in the maximum dose of 20 mg/kg prevented the development of acute generalized tonic-clonic kainate seizures in 60% rats, but did not alleviate clonic kainate seizures and prevented chronic kainate lethality in only 30% rats. Intramuscular ...

journal_title：Bulletin of experimental biology and medicine

authors： Serdyuk SE,Gmiro VE,Veselkina OS

更新日期：2014-05-01 00:00:00

abstract：:The risk of essential arterial hypertension was assessed in carriers of the NOS2 gene variants (rs1800482 (-954G>C), rs3730017 (C>T)). In subjects carrying C allele (rs1800482), the risk for essential arterial hypertension developing was higher by 1.7 times (OR=1.712, 95%CI 1.07-2.74), while the presence of T-allele (...

journal_title：Bulletin of experimental biology and medicine

authors： Topchieva LV,Balan OV,Korneeva VA,Malysheva IE

更新日期：2019-11-01 00:00:00

abstract：:The production of blood radicals and activity of superoxide dismutase in erythrocytes increased in rats with contact burn trauma (20%). In animals with burn trauma antioxidant activity of the plasma was much lower, while myeloperoxidase content in the lung tissue and epidermis was higher than in control rats. The comp...

journal_title：Bulletin of experimental biology and medicine

authors： Mikhal'chik EV,Ivanova AV,Anurov MV,Titkova SM,Pen'kov LY,Korkina LG

更新日期：2004-09-01 00:00:00

abstract：:We showed for the first time that prolactin stimulates the synthesis and release of immunomodulating cytokines and lymphocyte-activating factors (e.g., interleukin-1) by peritoneal macrophages. Prolactin abolished the stress-induced inhibition of proliferation of peripheral blood lymphocytes and increased cell sensiti...

journal_title：Bulletin of experimental biology and medicine

authors： Fomicheva EE,Nemirovich-Danchenko EA,Korneva EA

更新日期：2004-06-01 00:00:00

abstract：:Exposure of rats with experimental diabetes mellitus to wide-band electromagnetic radiation generated by He-Ne laser and modulated by the pancreas and spleen is informing and phenomenological method prolonging animal life span, normalizing blood glucose level, and promoting regeneration of the pancreas. ...

journal_title：Bulletin of experimental biology and medicine

authors： Garyaev PP,Kokaya AA,Mukhina IV,Leonova-Garyaeva EA,Kokaya NG

更新日期：2007-02-01 00:00:00

abstract：:The hypolipidemic effect of Kwai, a preparation based on garlic powder (Allium sativum), depended on the initial content of cholesterol and/or triglycerides. This effect was most pronounced in patients with coronary heart disease with initial cholesterol >7.0 mmol/liter and triglyceride >1.92 mmol/liter. After treatme...

journal_title：Bulletin of experimental biology and medicine

authors： Chernyad'eva IF,Shil'nikova SV,Rogoza AN,Kukharchuk VV

更新日期：2003-05-01 00:00:00

abstract：:The local anaphylactic reaction and the effects of histamine during blocking of the slow sodium-calcium channels by isoptine were investigated in the spontaneously contracting oracle of the atrium of a guinea pig previously sensitized to egg albumin. Simultaneously with the intracellular recording of the potentials, i...

journal_title：Bulletin of experimental biology and medicine

authors： Khodorov BI,Voronovitskii EG,Ignat'eva VB

更新日期：1975-01-01 00:00:00

abstract：:We studied changes in cell cycle and apoptosis in normal keratinocytes and melanocytes after exposure to UV-B radiation. UV-B radiation modulated proliferation rate in the studied cell and produced an apoptosis-modulating effect in epidermal melanocytes. ...

journal_title：Bulletin of experimental biology and medicine

authors： Ruksha TG

更新日期：2009-05-01 00:00:00

abstract：:Calmodulin inhibitor W-7 did not cause changes in the quantal content of postsynaptic end-plate potentials (EPP) in newly formed synapses, but prevented facilitation of acetylcholine secretion induced by L-type Ca(2+)channels blocker nitrendipine. CaMKII inhibitor KN-62 produced similar effect and suppressed the incre...

journal_title：Bulletin of experimental biology and medicine

authors： Bogatcheva PO,Balezina OP

更新日期：2013-01-01 00:00:00

abstract：:Tropomyosin (Tpm) is one of the main regulatory proteins in the myocardium. In some heart pathologies, interchain disulfide crosslinking in the Tpm molecule occurs. In the ventricle, this change in the structural properties of the Tpm molecule affects calcium regulation of the actin-myosin interaction. Using an in vit...

journal_title：Bulletin of experimental biology and medicine

authors： Shchepkin DV,Matyushenko AM,Bershitsky SY,Kopylova GV

更新日期：2019-05-01 00:00:00

abstract：:Acute experiments on cats showed that dynorphin A(1-13) modulates pulse activity of afferent neurons and interneurons in the bulbar cardiovascular center against the background of stable blood pressure. ...

journal_title：Bulletin of experimental biology and medicine

authors： Mikhailova SD,Vasil'eva TV,Semushkina TM,Storozhakov GI

更新日期：2003-01-01 00:00:00

abstract：:We revealed some relationships between the level of orientation and exploratory behavior, functional activity of the immune system, and structural and functional organization of the CNS in animals. Significant differences in brain morphology and expression of cytokine IL-1 beta, type I IL-1 receptor, and erythropoieti...

journal_title：Bulletin of experimental biology and medicine

authors： Markova EV,Chernova TG,Fillimonov PN,Korotkova NA,Abramov VV,Kozlov VA

更新日期：2004-10-01 00:00:00

abstract：:hyperthermia caused hemodynamic disorders in the liver and degenerative and necrobiotic changes in hepatocytes of CBA mice. Total hepatocyte count decreased during restitution, this decrease being most pronounced 30 min after exposure. The number of binucleated cells also markedly decreased. The absence of necrotic ch...

journal_title：Bulletin of experimental biology and medicine

authors： Molodykh OP,Nepomnyashchikh LM,Lushnikova EL,Klinnikova MG

更新日期：2000-09-01 00:00:00

abstract：:We studied the effect of mesenchymal stromal cells and conditioned media on healing of full-thickness skin wound in rats. Cell transplantation to the wound bed did not accelerate wound closing and had no effect on the severity of inflammation, but increased vasculariza - tion of the granulation tissue in 14 days after...

journal_title：Bulletin of experimental biology and medicine

authors： Payushina OV,Butorina NN,Sheveleva ON,Domaratskaya EI

更新日期：2018-08-01 00:00:00

abstract：:The content of catecholamines and their metabolites in the brain and the relationship between cerebral catecholamine levels and their urinary excretion were studied in rats with 6-OHDA-induced hemiparkinsonism. 6-OHDA reduced brain concentrations of dopamine, DOPAC, and homovanilic acid and urinary excretion of dopami...

journal_title：Bulletin of experimental biology and medicine

authors： Chekhonin VP,Baklaushev VP,Kogan BM,Savchenko EA,Lebedev SV,Man'kovskaya IV,Filatova TS,Yusupova IU,Dmitrieva TB

更新日期：2000-08-01 00:00:00

abstract：:The intensity of calcium and phosphate accumulation in regenerating bone tissue decreased significantly during the posttraumatic period in 54 male CBA mice with acute hepatic intoxication. The formation of organic components of the bone decreased to a lesser degree. Creatine metabolism in the muscles of damaged segmen...

journal_title：Bulletin of experimental biology and medicine

authors： Stogov MV,Luniova SN,Tkachuk EA

更新日期：2010-10-01 00:00:00