Abstract：
:Calmodulin inhibitor W-7 did not cause changes in the quantal content of postsynaptic end-plate potentials (EPP) in newly formed synapses, but prevented facilitation of acetylcholine secretion induced by L-type Ca(2+)channels blocker nitrendipine. CaMKII inhibitor KN-62 produced similar effect and suppressed the increase in EPP quantal content caused by blockade of L-type Ca(2+)channels. Phosphatase PP2A inhibitor okadaic acid significantly facilitated secretion in newly formed synapses; the effect was completely blocked by KN-62. In mature synapses, okadaic acid had no effect on transmitter secretion. KN-62 increased EPP quantal content. We hypothesize that CaMKII produced different effects on acetylcholine secretion in mature and immature synapses depending on specificity of calcium signaling and PP2A phosphatase activity.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Bogatcheva PO,Balezina OPdoi
10.1007/s10517-013-1940-8subject
Has Abstractpub_date
2013-01-01 00:00:00pages
316-9issue
3eissn
0007-4888issn
1573-8221journal_volume
154pub_type
杂志文章abstract：:Study on a model of 6-day dosed adaptation to heat in rats showed that this adaptation decreased the severity of cardiac arrhythmias during ischemic and reperfusion injury. The duration of arrhythmias decreased not only in the ischemic period, but also under conditions of reperfusion. Adaptation delayed the developmen...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-007-0003-4
更新日期：2007-01-01 00:00:00
abstract：:Studies of the effects of Trichoderma harzianum Rifai F-180 culture fluid concentrate containing L-lysine-α-oxidase antitumor enzyme produced by the fungus and the homogenous enzyme, on ultrahazardous bacterium Acidovorax citrulli demonstrated the antibacterial activity of the concentrate. Trichoderma harzianum Rifai ...
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pub_type： 杂志文章
doi：10.1007/s10517-018-4012-2
更新日期：2018-03-01 00:00:00
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journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-009-0708-7
更新日期：2009-08-01 00:00:00
abstract：:We studied the effect of continuous vibration and treatment with licorice root (Glycyrrhiza glabra L.) on peripheral blood red cells in rabbits. Active substances of licorice root accelerated metabolism in cells of the bone marrow erythroid stem, enhanced compensatory reserve of the organism, and increased animal's re...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-005-0444-6
更新日期：2005-08-01 00:00:00
abstract：:Reductase activity of 17beta-hydroxysteroid oxidoreductase in biopsy specimens of prostatic cancer and benign hyperplasia, and prostatic intraepithelial neoplasia and serum concentrations of testosterone, 5alpha-dihydrotestosterone, 4-androstene-3,17-dione were compared in patients and healthy individuals. Reductase a...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-005-0387-y
更新日期：2005-06-01 00:00:00
abstract：:Structural modifications of the gastric tube transplant were studied during the delayed period after esophagoplasty carried out for benign diseases of the esophagus. Adaptive and pathological reactions manifesting in atrophic and sclerotic changes in the mucosa formed the basis for transplant reorganization. The leadi...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-010-1016-y
更新日期：2010-10-01 00:00:00
abstract：:Comparative analysis of the parameters of LPO, antioxidant defense (AOD), and the thiol/disulfide system was performed in fertile and infertile males of reproductive age carrying different genotypes of the glutathione system genes. Blood plasma, blood hemolysate, and ejaculate served as specimens for biochemical studi...
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更新日期：2017-07-01 00:00:00
abstract：:Ultrastructure of myocardial microvessels was examined during surgical correction of congenital heart disease (ventricular septal defect) under conditions of cold and pharmacological low-potassium cardioplegia without perfusion. Addition of calcium antagonist verapamil to cardioplegic solution prevented postischemic d...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1023/a:1013154231069
更新日期：2001-09-01 00:00:00
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doi：10.1007/s10517-009-0439-9
更新日期：2009-01-01 00:00:00
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pub_type： 杂志文章
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更新日期：2005-11-01 00:00:00
abstract：:The effects of a new thietanylbenzimidazole derivative (K-134) on estrous cycles, conception processes, and sexual behavior of female rats were studied. Two-week oral treatment with K-134 in doses of 5 and 50 mg/kg shortened the estrus phase and prolonged proestrus. Changes in sexual behavior were presented by activat...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-015-3034-2
更新日期：2015-09-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/s10517-013-2322-y
更新日期：2013-12-01 00:00:00
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journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1023/a:1015530318241
更新日期：2002-02-01 00:00:00
abstract：:Metabolic processes in the brain cortex of albino rats with prenatal and postnatal alcohol intoxication were studied by the method of electron paramagnetic resonance. Accumulation of superoxide radical-generating agents, inactivation of superoxide dismutase, and increase in nitric oxide concentration were detected. Ac...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-006-0347-1
更新日期：2006-09-01 00:00:00
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journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-013-1960-4
更新日期：2013-01-01 00:00:00
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journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-016-3193-9
更新日期：2016-02-01 00:00:00
abstract：:Lyzed epimastigotes of Trypanosoma cruzi clones P209-1, Gamba1, Sp104-1, MASu, Y7/1, MN12, Cl-Brener, 86/2036, Y7/2-1 inhibit the growth of Ehrlich adenocarcinoma in mice. the tumor decreased 1.5-3 times after 12 daily injections of lysates from 15 million epimastigotes. The protective effect progressed after the inje...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-006-0395-6
更新日期：2006-10-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/s10517-018-4287-3
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doi：10.1007/s10517-010-0845-z
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doi：10.1007/s10517-009-0483-5
更新日期：2009-02-01 00:00:00
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pub_type： 杂志文章,随机对照试验
doi：10.1007/s10517-010-0744-3
更新日期：2009-09-01 00:00:00
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journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
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更新日期：2019-11-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/s10517-014-2473-5
更新日期：2014-04-01 00:00:00
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journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
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更新日期：2013-08-01 00:00:00
abstract：:Changes in heart rate and stroke volume after successive blockade of cardiac adreno- and cholinoceptors were examined on rats of different age. It was established that irrespective of animal age the heart rate remained unchanged under conditions of total adreno- and cholinergic blockade of the heart. Stroke volume und...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-006-0278-x
更新日期：2006-07-01 00:00:00
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journal_title：Bulletin of experimental biology and medicine
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更新日期：2018-07-01 00:00:00
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journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-019-04521-0
更新日期：2019-07-01 00:00:00
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journal_title：Bulletin of experimental biology and medicine
pub_type： 临床试验,杂志文章
doi：10.1023/b:bebm.0000017083.58029.ca
更新日期：2003-11-01 00:00:00
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journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-018-4197-4
更新日期：2018-08-01 00:00:00
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journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1023/a:1013659026064
更新日期：2001-10-01 00:00:00
