Abstract:
:Secretion and synthesis of vasopressin was studied in adult male Wistar rats receiving lipopolysaccharide in a dose of 250 microg/100 g body weight and subjected to moderate osmotic stimulation (2% NaCl perorally for 6 days). Lipopolysaccharide stimulated secretion of vasopressin into the blood. It should be emphasized that the content of vasopressin mRNA in gigantocellular nuclei of the hypothalamus decreased, which probably reflected intensification of its translation. The observed changes and slight increase in transcription of the vasopressin gene (determined by the content of heterogeneous nuclear RNA) provide intensive secretion of this neurohormone into the blood.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Liskina EB,Grinevich VV,Volkova OV,Akmaev IGdoi
10.1023/a:1026350403449subject
Has Abstractpub_date
2003-08-01 00:00:00pages
129-31issue
2eissn
0007-4888issn
1573-8221journal_volume
136pub_type
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