Abstract:
:Kinetics of DNA synthesis in mitotic cycle of in mouse corneal epithelial cells after γ-irradiation in different S phase points was studied by the method of autoradiography. Normally, S phase of corneal epithelial cells consists of two phases (S1 and S2) separated by an interval without DNA synthesis. Each phase, in turn, includes two subphases with a pause in DNA synthesis. It was hypothesized that pauses in DNA synthesis, similar to that during presynthetic g1 phase, correspond to periods of cell preparation to the next stage of their development. After irradiation, reparation proceeds during pauses at different phases of the cell cycle. The mechanism of reparation induces cell genome rearrangement.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Shabalkin IP,Grigor'eva EY,Shabalkin PI,Gudkova MVdoi
10.1007/s10517-014-2715-6subject
Has Abstractpub_date
2014-11-01 00:00:00pages
170-5issue
1eissn
0007-4888issn
1573-8221journal_volume
158pub_type
杂志文章abstract::Elimination of platelets from guinea pig splenocyte suspension (lacking megakaryocytes) with EDTA considerable reduces the efficiency cloning of splenic stromal precursor cells. It means that platelet-derived growth factors are necessary for stromal precursor cells from different organs (bone marrow, thymus, and splee...
journal_title:Bulletin of experimental biology and medicine
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journal_title:Bulletin of experimental biology and medicine
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更新日期:2016-02-01 00:00:00
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journal_title:Bulletin of experimental biology and medicine
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journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
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