New Effect in Physiology of Human Nervous Muscle System.

abstract：:We studied cardiac pumping function in the offspring of rats subjected to swimming exercise and the offspring of untrained rats. The rat pups were adapted for swimming with stepwise increasing load from day 21 to 70 life. At the age of 21 and 70 days, offspring of trained rats showed lower HR and significantly higher ...

journal_title：Bulletin of experimental biology and medicine

authors： Valeev AM,Abzalov NI,Abzalov RA,Nigmatullina RR,Abzalov RR,Nikitin AS

更新日期：2012-07-01 00:00:00

abstract：:Local injection of 4 nmol moxonidine (unilaterally) into the rostroventrolateral medulla of spontaneously hypertensive rats (SHR-SP) decreased mean blood pressure and heart rate by 24+/-3 and 3+/-4%, respectively. Pretreatment with the I1/alpha2-receptor antagonist efaroxan abolished the moxonidine-induced decrease in...

journal_title：Bulletin of experimental biology and medicine

authors： Khokhlova ON,Murashev AN,Medvedev OS

更新日期：2001-04-01 00:00:00

abstract：:Mutant alleles CYP2D63 and CYP2D64 were detected by PCR in 33 individuals. All examinees were given 50 mg methoprolol (orally). Plasma concentrations of the drug and its major metabolite was determined by high performance liquid chromatography and arterial pressure and heart rate were monitored. The rate of methoprolo...

journal_title：Bulletin of experimental biology and medicine

authors： Ramenskaya GV,Savchenko AY,Agafonov AA,Sychev DA,Andreev DA,Kukes VG

更新日期：2002-08-01 00:00:00

abstract：:Measurements with extracellular microelectrode technique showed that depolarization of motor nerve terminals in frog cutaneous pectoris muscle with high-potassium solution (40 mM K(+)) increased frequency of miniature end-plate currents. Both fast intracellular calcium chelator BAPTA-AM and slow chelator EGTA-AM equal...

journal_title：Bulletin of experimental biology and medicine

authors： Zefirov AL,Grigor'ev PN

更新日期：2008-12-01 00:00:00

abstract：:Histaminergic contractile reactions of smooth muscles in rabbit lobar pulmonary arteries were studied using in vitro mechanographic technique. Histamine via activation of H-receptors induced a dose-dependent constriction of smooth muscle segments, while endothelium inhibited histamine-induced contractile reactions. Hi...

journal_title：Bulletin of experimental biology and medicine

authors： Kapilevich LV,Anfinogenova YD,Nosarev AV,Baskakov MB,Kovalev IV,D'yakova EY,Medvedev MA

更新日期：2001-08-01 00:00:00

abstract：:Experiments on rats showed that blockade of hyperpolarization-activated currents moderates tachycardia induced by beta-adrenoceptor agonist isoproterenol and potentiates the increase in stroke volume produced by this agonist. Electrical stimulation of the vagus nerve against the background of isoproterenol treatment a...

journal_title：Bulletin of experimental biology and medicine

authors： Zefirov TL,Ziyatdinova NI,Gainullin AA,Zefirov AL

更新日期：2002-05-01 00:00:00

abstract：:We studied the interaction between the sympathetic and parasympathetic parts of the autonomic nervous system in the regulation of smooth muscles in the femoral artery and trachea. It was shown that this regulation involves ganglionic serotoninergic neurons transmitting excitation to 5-HT, receptors in the effector tis...

journal_title：Bulletin of experimental biology and medicine

authors： Lazebnik LB,Lychkova AE

更新日期：2006-01-01 00:00:00

abstract：:We studied reactions of the granulocytic hemopoietic stem during hypoxia of different genesis and severity. Stimulation of granulocytopoiesis was determined by an increase in functional activity of granulomonocytic precursors due to changes in feeder capacity of cells in the hemopoiesis-inducing microenvironment and c...

journal_title：Bulletin of experimental biology and medicine

authors： Zyuz'kov GN,Dygai AM,Gol'dberg ED

更新日期：2005-03-01 00:00:00

abstract：:Model experiments on biomicroscopy of mesenteric microvessels in laboratory rats were performed to evaluate the effect of natural metabolites (e.g., amino acid glycine) on the microcirculation. The effect of glycine was determined from a change in the diameter of arterioles. Application of glycine (0.1 ml, 1 M) to the...

journal_title：Bulletin of experimental biology and medicine

authors： Podoprigora GI,Nartsissov YR

更新日期：2009-03-01 00:00:00

abstract：:Individual or combined administration of BCG vaccine and silicon dioxide to male mice induced a nonspecific stress response of the adrenal glands and gonads judging from changes in the concentration of blood cortisol and testosterone. The dynamics of cortisol concentration in the adrenal glands was similar, while chan...

journal_title：Bulletin of experimental biology and medicine

authors： Palchikova NA,Kuzminova OI,Utkina NV,Selyatitskaya VG,Shkurupiy VA

更新日期：2008-12-01 00:00:00

abstract：:In experiments on narcotized rats, BP in the left femoral artery as well as local electrical potential and electrical impedance of the symmetric segment of the right femoral artery were simultaneously recorded in situ with two extracellular nonpolarizable Ag/AgCl electrodes located along the artery at a distance of 3 ...

journal_title：Bulletin of experimental biology and medicine

authors： Revenko SV,Tikhomirova LN,Nesterov AV,Tarakanov IA

更新日期：2018-04-01 00:00:00

abstract：:Crossbred CC57BR/Mv mice inherited tryptophan oxygenase gene and predisposition to alcohol consumption from parent BALB/c and C57BL mice, respectively. In CC57BR/Mv mice no relationships were found between alcohol consumption, tryptophan oxygenase activity, and single nucleotide substitutions in intron 6 of the TDO2 g...

journal_title：Bulletin of experimental biology and medicine

authors： Kaledin VI,Klimova NV,Vasil'ev GV,Ivanova EA,Vasil'eva ED,Il'nitskaya SI

更新日期：2003-10-01 00:00:00

abstract：:We performed a comparative study of the cytotoxicity of cisplatin, JM216 complex, and aminonitroxyl platinum(IV) complexes for HeLa cells grown in monolayer and 3D culture. The growth dynamics of spheroids was studied and optimal conditions for evaluation of cytotoxicity were determined. Spheroids were less sensitive ...

journal_title：Bulletin of experimental biology and medicine

authors： Trigub ММ,Filatova NV,Areshidze DА,Sen' VD,Terentiev АА

更新日期：2020-02-01 00:00:00

abstract：:Fifty-six primary neuroendocrine lung tumors were examined morphologically and histologically and their apoptosis level was determined. Malignant carcinomas were characterized by increased apoptotic index and enhanced expression ofBcl-2, Bak, p53, and Ki-67 compared to typical carcinoid. However, apoptosis in these tu...

journal_title：Bulletin of experimental biology and medicine

authors： Pal'tsev MA,Demura SA,Kogan EA,Jaques G,Zende B

更新日期：2000-07-01 00:00:00

abstract：:Proinflammatory markers were evaluated in patients with chronic heart failure of ischemic origin and essential hypertension with preserved left-ventricular ejection fraction before and after a 6-month course of simvastatin therapy (20 mg/day). The study was carried out in 125 patients with diastolic dysfunction manife...

journal_title：Bulletin of experimental biology and medicine

authors： Pinchuk TV,Fedulaev YN,Khairetdinova GA,Denisova NN,Chura OV,Logunova IY

更新日期：2014-09-01 00:00:00

abstract：:Plasma γ-globulin fraction proteins, copper and zinc cations, and metal complexes formed by these cations and human serum γ-globulin induce blast transformation of splenocytes from BALB/c mice at a level comparable to that induced by concanavalin A. Zinc bound to γ-globulin reduces by 25% and copper in complex with th...

journal_title：Bulletin of experimental biology and medicine

authors： Cheknev SB,Grigorjeva EA,Nikolaeva TN,Pronin AV

更新日期：2011-03-01 00:00:00

abstract：:Adhesion activity of L. acidophilus NK1, L. fermentum 90 TS4, and C. albicans 506 B on female vaginal epithelium was studied. Adhesion of various lactobacillus species was hormone-dependent. Adhesion of C. albicans 506 B was not associated with estrogen level. The effects of synthetic drugs and phytopreparations used ...

journal_title：Bulletin of experimental biology and medicine

authors： Rybas YA,Bustamante RA,Kravtsov EG,Tchernitchin AN,Dalin MV

更新日期：2012-07-01 00:00:00

abstract：:We demonstrated specific changes in platelet structure in different types of tuberculous process, in particular, shift in the proportion between alpha-granules, dense granules, different disorders in the mitochondrial and lysosomal apparatus, etc. The role of platelets in immune process is studied. Redistribution of a...

journal_title：Bulletin of experimental biology and medicine

authors： Khechinashvili GN,Khvitiya NG

更新日期：2004-11-01 00:00:00

abstract：:The rats were divided into groups demonstrating extremely high and low stress reactivity depending on the results of testing for the nociceptive threshold and thermolability in response to bacterial lipopolysaccharide administration. Specific structural features of the nucleus and mitochondria were revealed in neurons...

journal_title：Bulletin of experimental biology and medicine

authors： Potanin MB,Tumanov VP,Pisarev VB

更新日期：2007-11-01 00:00:00

abstract：:The development and manufacturing of serum-free culture media allowing reducing the costs of preparations and standardizing the biotechnological process are important trends in biotechnology. Substitution of protein compounds in the serum-free media with recombinant analogues reduces the risk of contamination with var...

journal_title：Bulletin of experimental biology and medicine

authors： Bobik TV,Popov RY,Aliev TK,Mokrushina YA,Shamborant OG,Khurs EN,Knorre VD,Smirnov IV,Gabibov AG

更新日期：2019-07-01 00:00:00

abstract：:Spontaneous platelet aggregation was evaluated in patients with acute coronary syndrome on days 1, 3-5, and 8-12 of the disease. On day 1, aggregation was analyzed after aspirin, but before clopidogrel administration; during other periods after both antiaggregants. The mean levels of spontaneous aggregation after anti...

journal_title：Bulletin of experimental biology and medicine

authors： Mazurov AV,Khaspekova SG,Yakushkin VV,Khachikyan MV,Zyuryaev IT,Ruda MY

更新日期：2013-05-01 00:00:00

abstract：:We studied plus-maze behavior of inbred Krushinskii-Molodkina, Wistar, and black-hooded rats (originating from the Long-Evans outbred strain) differing by predisposition to audiogenic seizures. The severity of audiogenic seizures partially correlated with anxiety and negatively correlated with the total level of locom...

journal_title：Bulletin of experimental biology and medicine

authors： Surina NM,Kalinina TS,Volkova AV,Malikova LA,Poletaeva II,Rayevsky KS,Fedotova IB

更新日期：2011-05-01 00:00:00

abstract：:We studied the functional role of individual subtypes of muscarinic cholinoceptors in the pathogenesis of neuroleptic parkinsonism in rats. Blockade of M4 receptors prevented the development of extrapyramidal disorders, which was abolished by simultaneous blockade of M2 receptors. The data suggest that various subtype...

journal_title：Bulletin of experimental biology and medicine

authors： Dagaev SG,Fil'ko OA,Kubarskaya LG,Khrabrova AV,Mukovskii LA,Glukhova RI,Sanotskii VI,Dolgo-Saburov VB

更新日期：2004-05-01 00:00:00

abstract：:A course of ascovertin therapy reduced manifestations of perifocal inflammation and atresia of growing follicles, corrected vascular disorders and changes in the tissue volume ratios outside the necrotic zone after monopolar coagulation of the ovaries in rats. The drug prevented the increase in blood viscosity, erythr...

journal_title：Bulletin of experimental biology and medicine

authors： Logvinov SV,Plotnikov MB,Tikhonovskaya OA,Bukharina IY,Maslov MY,Petrova MS

更新日期：2003-04-01 00:00:00

abstract：:Preliminary injection of succinic semialdehyde into animals in experiments with hypoxia led to a lower concentration of free ammonia in their brain tissues than in control experiments in which the compound was not given. The enzyme system of the liver tissue catalyzes the oxidation of NAD-H-2 by succinic semialdeyde a...

journal_title：Bulletin of experimental biology and medicine

authors： Zubovskaya AM,Ostrovskaya RU,Tsybina NM

更新日期：1975-01-01 00:00:00

abstract：:No appreciable disorders of cellular immunity were detected in patients with glandular cystic endometrial hyperplasia. Atypical endometrial hyperplasia was associated with quantitative changes in T lymphocytes and their subpopulations, decreased level of lymphocytes carrying activation antigens, and increased count of...

journal_title：Bulletin of experimental biology and medicine

authors： Lysenko ON,Strizhova NV,Kholodova ZhL

更新日期：2003-01-01 00:00:00

abstract：:The concentrations of the key factors of molecular pathogenesis of prehypertension (angiotensin II, HLDF24, S100b, endothelin, autoantibodies to these molecules, and VEGF) were analyzed in subjects with optimal BP (<120/80 mm Hg) and prehypertension (120-139/80-89 mm Hg). Comparative and correlation analysis of the le...

journal_title：Bulletin of experimental biology and medicine

authors： Sherstnev VV,Gruden MA,Karlina VP,Ryzhov VM,Kuznetsova AV,Senko OV

更新日期：2020-01-01 00:00:00

abstract：:Experiments on rat model of toxic liver damage (CCl4, subcutaneously) have demonstrated that selenium nanopreparation on arabinogalactan matrix and partially arabinogalactan alone prevented the development of oxidative stress assessed by the balance of LPO and antioxidant defense processes. ...

journal_title：Bulletin of experimental biology and medicine

authors： Kolesnikova LI,Karpova EA,Vlasov BY,Sukhov BG,Mov BA

更新日期：2015-06-01 00:00:00

abstract：:The formation of an ischemic focus in the myocardium is paralleled by autoimmune processes involving immunoglobulins with abnormal thermal solubility, cryoglobulins. Serum levels of cryoglobulins and their complexes were measured in 25 patients with Q-forming myocardial infarction on days 1, 2, 3, 7, and 14 of the dis...

journal_title：Bulletin of experimental biology and medicine

authors： Konstantinova NA,Yeremin II,Konstantinova EV,Karandashov EN,Shostak NA

更新日期：2011-02-01 00:00:00

abstract：:A simple method for the diagnosis of insulin resistance, easily realized in clinical practice, is developed in order to detect patients at a high risk of diseases associated with this condition. The metabolic index is estimated as the proportion of triglycerides and glucose values to quadratic HDL cholesterol value (i...

journal_title：Bulletin of experimental biology and medicine

authors： Roitberg GE,Dorosh ZhV,Sharkhun OO

更新日期：2015-01-01 00:00:00