Abstract:
:We studied the functional role of individual subtypes of muscarinic cholinoceptors in the pathogenesis of neuroleptic parkinsonism in rats. Blockade of M4 receptors prevented the development of extrapyramidal disorders, which was abolished by simultaneous blockade of M2 receptors. The data suggest that various subtypes of muscarinic receptors are involved in the regulation of dopamine concentration.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Dagaev SG,Fil'ko OA,Kubarskaya LG,Khrabrova AV,Mukovskii LA,Glukhova RI,Sanotskii VI,Dolgo-Saburov VBdoi
10.1023/b:bebm.0000038155.56296.50subject
Has Abstractpub_date
2004-05-01 00:00:00pages
468-70issue
5eissn
0007-4888issn
1573-8221pii
doijournal_volume
137pub_type
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