Effect of potentiated antibodies to cyclophosphamide on the development of tumors and effectiveness of cytostatic therapy under experimental conditions.

abstract：:Serum concentration of copper, immunoreactive polypeptides of ceruloplasmin and its oxidase activity, and the number of copper atoms per ceruloplasmin molecule were decreased in patients with Parkinson's disease in comparison with the corresponding parameters in age-matched healthy individuals, but the ratio of apocer...

journal_title：Bulletin of experimental biology and medicine

authors： Karpenko MN,Ilyicheva EY,Muruzheva ZM,Milyukhina IV,Orlov YA,Puchkova LV

更新日期：2018-03-01 00:00:00

abstract：:Addition of anaferon (pediatric formulation) to the therapy of chickenpox patients led to more rapid disappearance of the main symptoms and alleviated the course of the disease. The safety of the preparation is confirmed by the absence of undesirable events and stability of laboratory indexes against the background of...

journal_title：Bulletin of experimental biology and medicine

authors： Timchenko VN,Pavlova EB,Chernova TM,Bannova SL,Savel'eva TI,Tarasov SA,Kachanova MV,Siver'yanova MA

更新日期：2009-08-01 00:00:00

abstract：:Newborn rats received intraperitoneal injections of endothelin-1 in a daily dose of 5 x 10(-8)mol/kg 30 min after administration of NG-nitro-L-arginine methyl ester (9.3 x 10(-5)mol/kg intraperitoneally) from the 2nd to 6th day of life. NADPH diaphorase activity in epithelial and smooth muscle cells of the tracheobron...

journal_title：Bulletin of experimental biology and medicine

authors： Lebed'ko OA,Timoshin SS,Tsygankov VI

更新日期：2002-03-01 00:00:00

abstract：:Nadcin in a dose of 90 mg/kg administered to dogs with subacute stage of ischemia-reperfusion myocardial injury immediately after blood flow resumption normalized redox potential of cardiomyocytes and mitochondria and restored the total content of adenyl and pyridine nucleotides. The decrease in the synthesis of ATP a...

journal_title：Bulletin of experimental biology and medicine

authors： Sukoyan GV,Kavadze IK

更新日期：2008-09-01 00:00:00

abstract：:The hemostimulating effect of erythropoietin immobilized by the nanotechnology method of electron-beam synthesis was studied on the model of carboplatin-induced myelosuppression. Subcutaneous injection or oral administration of immobilized erythropoietin was followed by stimulation of erythropoiesis. The effect was mo...

journal_title：Bulletin of experimental biology and medicine

authors： Dygai AM,Zyuz'kov GN,Zhdanov VV,Artamonov AV,Bekarev AA,Madonov PG,Kinsht DN,Udut EV,Miroshnichenko LA,Khrichkova TY,Simanina EV,Stavrova LA,Chaikovskiy AV,Markova TS,Minakova MY

更新日期：2011-06-01 00:00:00

abstract：:The concentration of tissue inhibitor of type 1 metalloproteinases in blood serum from intact CBA mice measured by enzyme immunoassay is similar to that in healthy humans. The concentration of tissue inhibitor of type 1 metalloproteinases in mouse bile was higher than in blood serum, while its concentration in liver h...

journal_title：Bulletin of experimental biology and medicine

authors： Korolenko TA,Filatova TG,Savchenko NG,Yuz'ko YV,Goncharova IA,Alexeenko TV

更新日期：2007-03-01 00:00:00

abstract：:The development and manufacturing of serum-free culture media allowing reducing the costs of preparations and standardizing the biotechnological process are important trends in biotechnology. Substitution of protein compounds in the serum-free media with recombinant analogues reduces the risk of contamination with var...

journal_title：Bulletin of experimental biology and medicine

authors： Bobik TV,Popov RY,Aliev TK,Mokrushina YA,Shamborant OG,Khurs EN,Knorre VD,Smirnov IV,Gabibov AG

更新日期：2019-07-01 00:00:00

abstract：:In some patients with stable and unstable angina pectoris and in some donors without clinical manifestations of cardiovascular diseases and other pathologies, spontaneous platelet aggregation was completely suppressed by glycoprotein IIb-IIIa antagonists blocking the interaction of this glycoprotein with fibrinogen. A...

journal_title：Bulletin of experimental biology and medicine

authors： Sirotkina OV,Zabotina AM,Taraskina AE,Sivachenko EB,Zueva EE,Kadinskaya MI,Buryachkovskaya LI,Uchitel' IA,Khaspekova SG,Vavilova TV,Shvartsman AL,Mazurov AV

更新日期：2007-04-01 00:00:00

abstract：:Antiviral properties of Hexoral (0.1% solution and 0.2% aerosol for local application) and its constituent hexetidine against viruses causing human respiratory tract infections and herpes virus were studied in vitro. It was found that non-cytotoxic concentrations of hexetidine (alone and as a component of Hexoral) att...

journal_title：Bulletin of experimental biology and medicine

authors： Deryabin PG,Galegov GA,Andronova VA,Botikov AG

更新日期：2016-01-01 00:00:00

abstract：:The number of CD3(+)CD56-HLA-G(+) cells in the peripheral blood of breast cancer patients was shown to increase by 2 times. Our results and published data suggest that the increase in the relative content of CD3(+)CD56-HLA-G(+) cells in the circulating blood in breast cancer contributes to tumor development due to sup...

journal_title：Bulletin of experimental biology and medicine

authors： Ostapchuk EO,Perfi L'eva YV,Talaeva ShZh,Omarbaeva NA,Belyaev NN

更新日期：2015-09-01 00:00:00

abstract：:We studied the effect of transfection of PC-3 prostate cancer cells with a plasmid encoding shRNA complimentary to a fragment of integrin β4 (ITGB4). The results attest to considerable changes in the transcriptome of transfected cells. For instance, compensatory changes in the expression of integrin family genes were ...

journal_title：Bulletin of experimental biology and medicine

authors： Knyazev EN,Nyushko KM,Alekseev BY,Samatov TR,Shkurnikov MY

更新日期：2015-08-01 00:00:00

abstract：:Chinese hamster cells in culture were blocked in prometaphase by the addition of chloral hydrate. After 2 h the chloral hydrate was removed and the ultrastructural changes in the kinetochore studied during recovery of mitosis. The kinetochore in the blocked cells is a disc measuring 300-350 nm in diameter and 30-35 nm...

journal_title：Bulletin of experimental biology and medicine

authors： Alov IA,Lyubskii SL

更新日期：1975-01-01 00:00:00

abstract：:Effect of afobazole on the threshold of electrical fibrillation of the heart was studied on anesthetized rats with intact myocardium. It was shown that the drug considerably increased the threshold of electrical fibrillation of the heart, being not inferior to reference class I antiarrhythmic drugs (lidocaine and proc...

journal_title：Bulletin of experimental biology and medicine

authors： Kryzhanovskyi SA,Stolyaruck VN,Vititnova MB,Tsorin IB,Seredenin SB

更新日期：2010-09-01 00:00:00

abstract：:We studied regulation of hypoxanthine transport depending on its concentration in the culture medium. Caco-2 cells were differentiated on membrane filters to create a model of the intestine. Different hypoxanthine uptake on the apical and basolateral cell membranes was observed. The expression of SLC29 family genes en...

journal_title：Bulletin of experimental biology and medicine

authors： Senyavina NV,Tonevitskaya SA

更新日期：2015-11-01 00:00:00

abstract：:We designed a new complex drug with antiallergic effect containing, in addition to the main component loratadine, a phytocomplex for an extra therapeutic effect. A collection of plants with sedative activity is chosen and the optimal agent for extraction of bioactive compounds (40% ethanol) and optimal degree of plant...

journal_title：Bulletin of experimental biology and medicine

authors： Kulikovskii VF,Zhilyakova ET,Novikov OO,Pisarev DI,Prokushchenko NV,Ivanova LL

更新日期：2017-10-01 00:00:00

abstract：:We studied the effect of allopregnanolone on stress-induced anxiety caused by intranasal administration of corticoliberin to male Wistar rats. Active and passive rats were selected by their T-maze behavior and then were tested in elevated plus maze for initial anxiety level. Basing on test results, the animals were di...

journal_title：Bulletin of experimental biology and medicine

authors： Semenova OG,Rakitskaya VV

更新日期：2014-04-01 00:00:00

abstract：:The inotropic response of the myocardium to extrasystolic treatment was studied on isolated perfused papillary muscles from rats with postinfarction cardiosclerosis. The development of postinfarction cardiosclerosis was accompanied by a decrease in myocardial excitability. The amplitude of extrasystolic contractions i...

journal_title：Bulletin of experimental biology and medicine

authors： Kondrat'eva DS,Afanas'ev SA,Falaleeva LP,Shakhov VP

更新日期：2005-06-01 00:00:00

abstract：:Therapy of rats with CCl4 hepatitis with Stellaria media L. water-soluble polysaccharide fraction in a dose of 100 mg/kg reduces serum activities of transaminases (ALT and AST), alkaline phosphatase, bilirubin, and the thymol test values. In the liver, the density of inflammatory infiltration of the organ parenchyma, ...

journal_title：Bulletin of experimental biology and medicine

authors： Gorina YV,Saprykina EV,Gereng EA,Perevozchikova TV,Krasnov EA,Ivanova EV,Fait EA,Baranova OV

更新日期：2013-03-01 00:00:00

abstract：:Here we review the mechanisms underlying systemic regulation of the genome in brain nerve cells. Expression of early and late behavioral genes is regulated by systemic processes in dominant functional systems. The main elements of this molecular and genetic cascade are similar during learning and development. ...

journal_title：Bulletin of experimental biology and medicine

authors： Anokhin KV,Sudakov KV

更新日期：2003-02-01 00:00:00

abstract：:The rats were divided into groups demonstrating extremely high and low stress reactivity depending on the results of testing for the nociceptive threshold and thermolability in response to bacterial lipopolysaccharide administration. Specific structural features of the nucleus and mitochondria were revealed in neurons...

journal_title：Bulletin of experimental biology and medicine

authors： Potanin MB,Tumanov VP,Pisarev VB

更新日期：2007-11-01 00:00:00

abstract：:The paper analyzes theoretical models of the adaptive modes of generation and stability of human heart as a nonlinear point source. The analysis encompasses only ECG time-domain dynamics. To solve the general problem of the study of the adaptive changes of the cardiosignal under the action of external periodic force a...

journal_title：Bulletin of experimental biology and medicine

authors： Pipin VV,Ragulskaya MV,Chibisov SM

更新日期：2010-10-01 00:00:00

abstract：:Experiments on "stationary aging" cultures of B11dii-FAF28 Chinese hamster cells showed that contact inhibition of cell growth and further culturing of cells in the stationary phase led to continuous inhibition of enzymes realizing poly-ADP-ribosylation of chromatin proteins. Cell density in the monolayer and percenta...

journal_title：Bulletin of experimental biology and medicine

authors： Shram SI,Shilovskii GA,Khokhlov AN

更新日期：2006-05-01 00:00:00

abstract：:Delayed consequences of acute hypoxia were studied in 60-day-old rat pups. The animals were exposed to acute hypobaric hypoxia on day 10 of embryogenesis. The offspring of intact females served as the control. Reactivity of mesenteric lymphatic vessels to norepinephrine was studied by vital microscopy. The frequency a...

journal_title：Bulletin of experimental biology and medicine

authors： Sanzhieva LTs,Graf AS,Maslova MV,Lelekova TV,Sokolova NA

更新日期：2004-07-01 00:00:00

abstract：:The immunolocalization of apoptotic factors in rat neocortex was studied on the model of permanent occlusion of the middle cerebral artery with administration of exogenous BDNF. We revealed heterogeneous distribution of pro- and anti-apoptotic factors in the stroke area and in the surrounding penumbra, where caspase-3...

journal_title：Bulletin of experimental biology and medicine

authors： Kalinichenko SG,Matveeva NY,Korobtsov AV

更新日期：2020-09-01 00:00:00

abstract：:Experiments on rats showed that activation of the peripheral ion channel TRPM8 with menthol and rapid cooling (decrease in core temperature by 3°C) led to 1.5-fold activation of the expression of TRPV3 ion channel gene in the posterior hypothalamus, but had no effect on the expression of this gene in the anterior hypo...

journal_title：Bulletin of experimental biology and medicine

authors： Kozyreva TV,Evtushenko AA,Voronova IP,Khramova GM,Kozaruk VP

更新日期：2018-12-01 00:00:00

abstract：:We propose a noninvasive method of in vivo examination the hemostasis system based on speckle pattern analysis of coherent light scattering from the skin. We compared the results of measuring basic blood coagulation parameters by conventional invasive and noninvasive methods. A strict correlation was found between the...

journal_title：Bulletin of experimental biology and medicine

authors： Kuznik BI,Fine IW,Kaminsky AV

更新日期：2011-09-01 00:00:00

abstract：:We studied brown adipose tissue isolated from mice receiving 20% ethanol as a single source of fluid. In vitro O2 utilization by brown adipose tissue decreased after one month of forced alcohol intake, but surpassed the control after 3 months of ethanol drinking. The absolute and relative weight of brown adipose tissu...

journal_title：Bulletin of experimental biology and medicine

authors： Elsukova EI,Medvedev LN,Kudryavtseva NA

更新日期：2001-12-01 00:00:00

abstract：:Proinflammatory markers were evaluated in patients with chronic heart failure of ischemic origin and essential hypertension with preserved left-ventricular ejection fraction before and after a 6-month course of simvastatin therapy (20 mg/day). The study was carried out in 125 patients with diastolic dysfunction manife...

journal_title：Bulletin of experimental biology and medicine

authors： Pinchuk TV,Fedulaev YN,Khairetdinova GA,Denisova NN,Chura OV,Logunova IY

更新日期：2014-09-01 00:00:00

abstract：:Treadmill training of spinalized rats creates conditions for early appearance of rhythmic locomotor movements of the hind limbs. Recovery of the movements was paralleled by an appropriate structural organization of neurons in the anterior horns of the distal compartment of the spinal cord. ...

journal_title：Bulletin of experimental biology and medicine

authors： Moshonkina TR,Gilerovich EG,Fedorova EA,Avelev VD,Gerasimenko YP,Otellin VA

更新日期：2004-08-01 00:00:00

abstract：:Using comet assay we studied the effect of anxiolytic afobazole, exhibiting also antioxidant and antimutagenic properties, on spontaneous and ex-vivo hydrogen peroxide-induced DNA damage in blood cells from patients with systemic lupus erythematosus. Afobazole treatment (30-60 mg/day for 1 month) in addition to standa...

journal_title：Bulletin of experimental biology and medicine

authors： Zhanataev AK,Lisitsyna TA,Durnev AD,Nasonov EL,Seredenin SB

更新日期：2009-10-01 00:00:00