Effect of Activation of Peripheral Ion Channel TRPM8 on Gene Expression of Thermosensitive TRP Ion Channels in the Hypothalamus. Comparison with the Effect of Cooling.

abstract：:We studied the effects of a concentrate of metabolites of Trichoderma harzianum Rifai F-180, an active producer of L-lysine-α-oxidase, and homogenous enzyme on a highly virulent bacteria Erwinia amylovora. The producer of antitumor and antiviral Trichoderma enzyme L-lysine-α-oxidase was cultured on a processing system...

journal_title：Bulletin of experimental biology and medicine

authors： Smirnova IP,Karimova EV,Shneider YA

更新日期：2017-10-01 00:00:00

abstract：:The antidepressant, psychostimulant, and nootropic effects of a composition of major and trace elements including KCl, RbNO3, magnesium sulfate, and zinc sulfate were studied on the models of behavioural despair (Porsolt test) and conditioned passive avoidance test. The preparation was found to shorten the immobilizat...

journal_title：Bulletin of experimental biology and medicine

authors： Afanasieva OG,Suslov NI,Shilova IV

更新日期：2013-06-01 00:00:00

abstract：:Functional activity of the thyroid gland is reduced in Wistar rats with acute experimental endotoxicosis developing in response to sublethal dose of LPS and paralleled by polarization of the immune response by the Th-1 type. This decrease does not depend on the level of thyrotropic hormone and correlates with the prod...

journal_title：Bulletin of experimental biology and medicine

authors： Yaglova NV

更新日期：2009-06-01 00:00:00

abstract：:Comparative investigation of effects of antioxidant agents histochrom and emoxypin on biophysical characteristics of isolated neurons from shell Lymnaea stagnalis under normal conditions and during oxidative stress was performed. Differently directed effects of these compounds on resting potential and transmembrane io...

journal_title：Bulletin of experimental biology and medicine

authors： Mischenko NP,Fedoreev SA,Zapara TA,Ratushnyak AS

更新日期：2009-02-01 00:00:00

abstract：:We studied the rate of development of tolerance to the ethanol-induced analgesia under the effect of μ-, δ-, and κ-opioid agonists and antagonists not crossing the blood-brain barrier and rapidly inactivated by gastric and duodenal proteolytic enzymes. Activation of gastric κ-opioid receptors eliminated the analgesic ...

journal_title：Bulletin of experimental biology and medicine

authors： Sudakov SK,Alekseeva EV,Nazarova GA

更新日期：2017-06-01 00:00:00

abstract：:Alofanib is a potential allosteric inhibitor of FGFR2 used in oncology. The inhibitor blocks the extracellular part of the receptor and prevents its binding with the ligand. Alofanib suppressed proliferation of endothelial cells, their migration activity, and ability to form vessellike structures in vitro and signific...

journal_title：Bulletin of experimental biology and medicine

authors： Khochenkov DA,Solomko ES,Peretolchina NM,Ryabaya OO,Stepanova EV

更新日期：2015-11-01 00:00:00

abstract：:The immunobiological potential of a new microorganism species isolated from permafrost specimens (PMO strain 3M) collected from the Mammoth Mountain in Yakutia was studied in laboratory mice. PMO injected intraperitoneally in doses of 2500 to 50 × 10(6) microbial bodies caused characteristic dose-dependent effects on ...

journal_title：Bulletin of experimental biology and medicine

authors： Kalenova LF,Suhovey UG,Broushkov AV,Melnikov VP,Fisher TA,Besedin IM,Novikova MA,Efimova JA,Subbotin AM

更新日期：2011-06-01 00:00:00

abstract：:T cells were most sensitive to cyclophosphamide in DBA/2 mice, while in C57Bl/6 mice both T and B cells were sensitive. The formation of antibody-producing cells and the production of specific antibodies were delayed in DBA/2 mice immunized after pretreatment with antitumor drug. Accumulation of antibody-producing cel...

journal_title：Bulletin of experimental biology and medicine

authors： Masnaya NV,Churin AA,Borsuk OS,Sherstoboev EY

更新日期：2003-04-01 00:00:00

abstract：:In experiments on narcotized rats, BP in the left femoral artery as well as local electrical potential and electrical impedance of the symmetric segment of the right femoral artery were simultaneously recorded in situ with two extracellular nonpolarizable Ag/AgCl electrodes located along the artery at a distance of 3 ...

journal_title：Bulletin of experimental biology and medicine

authors： Revenko SV,Tikhomirova LN,Nesterov AV,Tarakanov IA

更新日期：2018-04-01 00:00:00

abstract：:We studied anticonvulsant effects of combined treatment with citicoline, a nootropic substance with neuroregenerative and neuroprotective activities, and valproate, an antiepileptic agent widely used in the treatment of epilepsy, on the model of pentylenetetrazole-induced (75 mg/kg, intraperitoneally) acute generalize...

journal_title：Bulletin of experimental biology and medicine

authors： Karpova MN,Kuznetsova LV,Zin'kovskii KA,Klishina NV

更新日期：2016-02-01 00:00:00

abstract：:Experiments on rats showed that blockade of hyperpolarization-activated currents moderates tachycardia induced by beta-adrenoceptor agonist isoproterenol and potentiates the increase in stroke volume produced by this agonist. Electrical stimulation of the vagus nerve against the background of isoproterenol treatment a...

journal_title：Bulletin of experimental biology and medicine

authors： Zefirov TL,Ziyatdinova NI,Gainullin AA,Zefirov AL

更新日期：2002-05-01 00:00:00

abstract：:We developed an optimal protocol for preparing and culturing of olfactory ensheathing cells from human olfactory mucosa. Using this protocol, we obtained a culture enriched with human olfactory ensheathing cells. Immunofluorescence analysis by simultaneous expression of GFAP and p75NTR markers showed that the content ...

journal_title：Bulletin of experimental biology and medicine

authors： Voronova АD,Stepanova OV,Valikhov MP,Chadin AV,Dvornikov АS,Reshetov IV,Chekhonin VP

更新日期：2018-03-01 00:00:00

abstract：:Activities of enzymes of active oxygen forms detoxication and phase II xenobiotic metabolism were measured in rat hepatoma 27 cells transplanted to different organs. Activity of phase II xenobiotic metabolizing enzymes was higher in hepatoma cells growing subcutaneously than in those transplanted into the liver, while...

journal_title：Bulletin of experimental biology and medicine

authors： Ostashkina NM,Dubovaya TK,Koblyakov VA,Konovalova GG,Lankin VZ

更新日期：2000-11-01 00:00:00

abstract：:We analyzed the concentration of extracellular DNA and its fractions in the dynamics of uncomplicated pregnancy Thirty women with singleton pregnancy were examined. The concentration of total, maternal, and fetal cell-free DNA in maternal blood was measured at gestation weeks 11-14, 24-26, and 30-32. The level of tota...

journal_title：Bulletin of experimental biology and medicine

authors： Karapetyan АО,Baev ОR,Krasnyi АМ,Sadekova АА,Мullabaeva SМ

更新日期：2018-11-01 00:00:00

abstract：:The development of dissociated cells from rat embryonic spinal ganglion after transplantation to damaged nerve of adult animals was studied using immunohistochemical differentiation markers of neural and glial cells. The cell suspension obtained after dissociation of rat embryonic spinal ganglia (embryonic day 15) was...

journal_title：Bulletin of experimental biology and medicine

authors： Petrova ES,Isaeva EN,Korzhevskii DE

更新日期：2014-09-01 00:00:00

abstract：:We studied the effects of calcitonin, parathyrin, and Ca(2+) channel antagonist isoptin and agonist Bay-K-8644 on glucose consumption by muscle (diaphragm) and adipose (epididymal) tissues and insulin-stimulated glucose consumption in vivo and in vitro. Calcitonin and parathyrin did not alter glucose consumption; para...

journal_title：Bulletin of experimental biology and medicine

authors： Butakova SS,Nozdrachev AD

更新日期：2009-08-01 00:00:00

abstract：:We studied the possibility of evaluation of the intensity of pathological oxidative processes in rat liver using an integral bioluminescent test with controlled perfusion of the isolated organ. The test revealed a significant correlation between the level of TBA-reactive products and bioluminescence intensity. ...

journal_title：Bulletin of experimental biology and medicine

authors： Remmel' NN,Kratasyuk VA,Maznyak OM,Inzhevatkin EV,Nefedov VP

更新日期：2003-01-01 00:00:00

abstract：:The stimulatory effect of a local focus of granulation tissue, created in the bone marrow cavity, on reparative osteogenesis after tibial bone fracture was detected in experimental rats by microscopic examination of histological sections, scanning electron microscopy, and X-ray electron probe microanalysis. ...

journal_title：Bulletin of experimental biology and medicine

authors： Ir'yanov YM,Dyuryagina OV

更新日期：2014-05-01 00:00:00

abstract：:Application of anxiolytic drug Selank to hippocampal slices increased the amplitude and discharge rate of spontaneous inhibitory postsynaptic currents in rat hippocampal pyramidal CA1 neurons. In some neurons, Selank-induced up-regulation of spontaneous inhibitory postsynaptic currents was preceded by a transient decr...

journal_title：Bulletin of experimental biology and medicine

authors： Povarov IS,Kondratenko RV,Derevyagin VI,Myasoedov NF,Skrebitsky VG

更新日期：2017-03-01 00:00:00

abstract：:Spontaneous and stimulated reaction of lymphocyte proliferation and blood levels of CD25- and CD120-expressing lymphocytes were studied in patients with autoimmune thyroiditis and diffuse toxic goiter. Activation of CD25- and CD120-presenting function of blood lymphocytes was revealed. The findings indicate that the c...

journal_title：Bulletin of experimental biology and medicine

authors： Urazova OI,Kravets EB,Nedosekova YV,Rogaleva AV,Kuznecova VN,Rumpel OA

更新日期：2008-09-01 00:00:00

abstract：:Intranigral administration of glutamate to rats with parkinsonian syndrome induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine augmented the development of parkinsonian symptoms (oligokinesia and muscular rigidity), but did not affect motor activity of intact animals. Memantine administered intraperitoneally in pa...

journal_title：Bulletin of experimental biology and medicine

authors： Kucheryanu VG,Kryzhanovskii GN

更新日期：2000-07-01 00:00:00

abstract：:Integral activity of neutral deoxyribonucleases in the plasma and urine or donors, patients with benign prostatic hyperplasia, and patients with stomach and prostatic cancer was studied by IFA based on hydrolysis of DNA fragment modified with haptene molecules. In donors plasma deoxyribonuclease activity was 0.16+/-0....

journal_title：Bulletin of experimental biology and medicine

authors： Tamkovich SN,Cherepanova AV,Bryzgunova OE,Kolesnikova EV,Permyakova VI,Vlassov VV,Laktionov PP

更新日期：2008-07-01 00:00:00

abstract：:Developed form of metabolic syndrome was revealed in 64.3% men with grade 1 obesity and in 81.8% men with grade 2-3 obesity (patients of the therapeutic clinic). The major components were dyslipidemia, fatty hepatosis, arterial hypertension, and hyperinsulinemia. In patients with excess body weight, changes in some bi...

journal_title：Bulletin of experimental biology and medicine

authors： Kogai MA,Lutov UV,Selyatitskaya VG

更新日期：2008-12-01 00:00:00

abstract：:The gene expression profiles of MDA-MB-231 cell line of breast cancer and xenografts derived from this tumor in murine model were analyzed using GeneChip Human Transcriptome array 2.0 platform (Affymetrix). A more than 1000-fold increase in the MIR1973 gene expression was observed in the xenografts compared to the ori...

journal_title：Bulletin of experimental biology and medicine

authors： Fomicheva KA,Knyazev EN,Mal'tseva DV

更新日期：2017-09-01 00:00:00

abstract：:Presentation of visual and acoustic stimuli at a rate of 2-30 Hz modulated variability of the heart rhythm in volunteers. Potentation of vagal influences and a decrease in the contribution of ergotropic systems to the regulation of the heart rate were noted after 10 sessions of audiovisual stimulation. These changes w...

journal_title：Bulletin of experimental biology and medicine

authors： Zagulova DV,Podkopaeva TI,Vasil'ev VN,Medvedev MA

更新日期：2001-03-01 00:00:00

abstract：:The development of experimental type II diabetes mellitus in rats was accompanied by dysfunction of inhibitory and stimulatory heterotrimeric G-proteins, components of hormone-sensitive adenylate cyclase signal system. The function of inhibitory G-proteins decreased most significantly under these conditions, which is ...

journal_title：Bulletin of experimental biology and medicine

authors： Shpakov AO,Kuznetsova LA,Plesneva SA,Bondareva VM,Guryanov IA,Vlasov GP,Pertseva MN

更新日期：2006-12-01 00:00:00

abstract：:We performed comparative analysis of hemodynamic in the periodontal microcirculatory bed in adolescents with arterial hypertension (AH) and morphological changes in the periodontal tissues of in hypertensive ISIAH rats of comparable biological age. In the periodontal tissues of adolescents with hypertension, the blood...

journal_title：Bulletin of experimental biology and medicine

authors： Kolesnikova LR,Darenskaya MA,Kolesnikova LI,Grebenkina LA,Korytov LI,Batoroev YK,Belinskaya EI,Mikhalevich IM,Kolesnikov SI

更新日期：2020-10-01 00:00:00

abstract：:We studied the effect of allotransplantation of bone marrow mononuclear cells on postinfarction remodeling of the heart in rats. The cells were transplanted into the periinfarction zone of the heart. The transplantation was performed on day 9 after coronary occlusion. It was found that on day 45 after coronary occlusi...

journal_title：Bulletin of experimental biology and medicine

authors： Maslov LN,Shakhov VP,Krylatov AV,Platonov AA

更新日期：2008-01-01 00:00:00

abstract：:A new universal method for measuring activity of the serum complement system in humans, laboratory, domestic, agricultural animals, birds and amphibians is based on automated evaluation of the mortality of ciliate Tetrahymena pyriformis under the effect of the complement system. In contrast to the hemolytic method, me...

journal_title：Bulletin of experimental biology and medicine

authors： Kuleshina ON,Kozlov LV,Cheremnykh EG

更新日期：2014-06-01 00:00:00

abstract：:Mice lacking dynein arms in the cilia were examined; the strain was obtained by inactivation of dynein heavy chain gene in chromosome 7. The cilia of these mice were examined by electron microscopy and compared to the cilia of random-bred mice. No statistically significant differences or typical disorders in the outer...

journal_title：Bulletin of experimental biology and medicine

authors： Ebsen M,Morgenroth K,Neesen J

更新日期：2004-06-01 00:00:00