Abstract:
:We studied the dynamics of indexes for the system of endogenous regulation of NO bioavailability. The content of NO synthase inhibitors (monomethylarginine and asymmetric dimethylarginine) in the blood of mice was measured after intraperitoneal injections of a nonionic surfactant poloxamer 407 for 2 and 14 weeks. The concentrations of both methylarginines in animals with atherosclerosis due to 14-week administration of poloxamer were much higher than in control specimens. The amount of arginine and symmetric dimethylarginine practically did not differ from the control. Poloxamer-induced model of atherosclerosis is characterized by increased content of NO synthase inhibitors. These changes contribute to the development of endothelial dysfunction and atherosclerosis.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Gilinsky MA,Sukhovershin RA,Cherkanova MSdoi
10.1007/s10517-015-3086-3subject
Has Abstractpub_date
2015-11-01 00:00:00pages
13-6issue
1eissn
0007-4888issn
1573-8221pii
10.1007/s10517-015-3086-3journal_volume
160pub_type
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