Abstract:
:Effect of the dipeptidyl peptidase-4 inhibitor linagliptin on structural manifestations of diabetic nephropathy was studied in BKS.Cg-Dock7m+/+Leprdb/J mice (experimental model of type 2 diabetes mellitus). Linagliptin (10 mg/kg per day) or vehicle was administered by gavage over 8 weeks. Mesangial expansion, thickening of the basement membrane in glomerular capillaries and proximal tubules, and retraction of cytopodia were less pronounced in mice receiving linagliptin. The protective effect of linagliptin on the kidney structure was not associated with its hypoglycemic action.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Gavrilova YS,Bgatova NP,Klimontov VV,Ischenko IY,Michurina SV,Myakina NE,Zavyalov ELdoi
10.1007/s10517-016-3447-6subject
Has Abstractpub_date
2016-08-01 00:00:00pages
501-4issue
4eissn
0007-4888issn
1573-8221pii
10.1007/s10517-016-3447-6journal_volume
161pub_type
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