Abstract：
:In acute experiments on cats neural inotropic and lusitropic reactions of the heart to enhancement of pre- and afterload were assessed by changes in contractility and relaxation indices, which were preliminary chosen for their maximum specificity and sensitivity. The control cardiac responses to increased pre- and afterload were measured after treatment with ganglionic blocker arfonad. The myogenic component of these responses assessed under the action of arfonad was highly pronounced, therefore the neural inotropic and lusitropic reactions were measured as the difference between load-induced changes of indices in experiments with and without arfonad. Increased preload produced similar negative inotropic and lusitropic effects, while increased afterload produced a more pronounced negative inotropic effect, which indicated independent regulation of contractility and diastolic relaxation of the heart.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Alipov NN,Sokolov AV,Trubetskaya LV,Kuznetsova TEdoi
10.1023/a:1024644310907subject
Has Abstractpub_date
2003-04-01 00:00:00pages
330-3issue
4eissn
0007-4888issn
1573-8221journal_volume
135pub_type
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