Abstract:
:The effects of phosphatidylcholine-based phospholipid nanoparticles containing fullerene C60 on Danio rerio fish embryos were studied. Exposure of the embryos with the nanoparticles for 48 h did not lead to appreciable changes in the number of protein bands in SDS-PAGE in comparison with the control (exposure in medium with phosphatidylcholine). Mass spectrometric identification of proteins showed differences in the proteomic profiles of the samples. The content of vitellogenins changed after exposure with phosphatidylcholine-based nanoparticles with C60 fullerenes. This could indicate low toxicity of the nanoparticles towards D. rerio embryos under experimental conditions.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Kuznetsova GP,Larina OV,Petushkova NA,Kisrieva YS,Samenkova NF,Trifonova OP,Karuzina II,Ipatova OM,Zolotaryov KV,Romashova YA,Lisitsa AVdoi
10.1007/s10517-014-2427-ysubject
Has Abstractpub_date
2014-03-01 00:00:00pages
694-8issue
5eissn
0007-4888issn
1573-8221journal_volume
156pub_type
杂志文章abstract::We studied the structure of rhythms of BP, HR (by telemetric monitoring), electrolyte excretion (by capillary electrophoresis), and products of epiphyseal melatonin (by the urinary concentration of 6-sulfatoxymelatonin measured by ELISA) in normotensive Wistar-Kyoto rats and spontaneously hypertensive SHR rats maintai...
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