Effects of fullerene C60 on proteomic profile of Danio rerio fish embryos.

Abstract:

:The effects of phosphatidylcholine-based phospholipid nanoparticles containing fullerene C60 on Danio rerio fish embryos were studied. Exposure of the embryos with the nanoparticles for 48 h did not lead to appreciable changes in the number of protein bands in SDS-PAGE in comparison with the control (exposure in medium with phosphatidylcholine). Mass spectrometric identification of proteins showed differences in the proteomic profiles of the samples. The content of vitellogenins changed after exposure with phosphatidylcholine-based nanoparticles with C60 fullerenes. This could indicate low toxicity of the nanoparticles towards D. rerio embryos under experimental conditions.

journal_name

Bull Exp Biol Med

authors

Kuznetsova GP,Larina OV,Petushkova NA,Kisrieva YS,Samenkova NF,Trifonova OP,Karuzina II,Ipatova OM,Zolotaryov KV,Romashova YA,Lisitsa AV

doi

10.1007/s10517-014-2427-y

subject

Has Abstract

pub_date

2014-03-01 00:00:00

pages

694-8

issue

5

eissn

0007-4888

issn

1573-8221

journal_volume

156

pub_type

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