Abstract:
:Two-year experiments were performed to evaluate the neurotrophic effect of hypoxia-inducible factors (vascular endothelial growth factor and angiogenin) expressed in recombinant human adenoviruses in amyotrophic lateral sclerosis. Randomized placebo-controlled trial demonstrated safety and good tolerability of the recombinant antiviral drugs. The life span of patients under conditions of hypoxia increased after treatment with the test drug, which was probably related to improved resistance of motoneurons. The presence of virus-neutralizing antibodies decreases the effectiveness of adenoviral vectors, which necessitates differential approach to the selection of patients and continuous monitoring of gene therapy.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Zavalishin IA,Bochkov NP,Suslina ZA,Zakharova MN,Tarantul VZ,Naroditskiy BS,Suponeva NA,Illarioshkin SN,Shmarov MM,Logunov DY,Tutyhina IL,Verkhovskaya LV,Sedova ES,Vasiliev AV,Brylev LV,Ginzburg ALdoi
10.1007/s10517-008-0124-4subject
Has Abstractpub_date
2008-04-01 00:00:00pages
483-6issue
4eissn
0007-4888issn
1573-8221pii
doijournal_volume
145pub_type
杂志文章,随机对照试验abstract::The degree of oxygen consumption in rats was determined after intraperitoneal injection of morphine in a single dose of 5 mg/kg. Some animals were injected with morphine and perorally received morphine or antibodies to mu-opiate receptors in ultralow doses obtained by the technology of potentiation. Potentiated substa...
journal_title:Bulletin of experimental biology and medicine
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