Abstract:
:The effects of norepinephrine on the heart rate were studied in 1-, 3-, 6-, and 20-week-old rats before and after blockade of hyperpolarization-activated currents (I f , I h ). In animals with mature sympathetic regulation of cardiac activity (6- and 20-week-old animals), I f blockage decreased the severity of norepinephrine-induced tachycardia. In newborn rats lacking sympathetic innervation of the heart, norepinephrine only slightly affected heart rate before and after I f blockage. In 3-week-old animals, I f blockage after norepinephrine pretreatment increased tachycardia.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Ziyatdinova NI,Dement'eva RE,Khisamieva LI,Zefirov TLdoi
10.1007/s10517-013-2262-6subject
Has Abstractpub_date
2013-11-01 00:00:00pages
1-3issue
1eissn
0007-4888issn
1573-8221journal_volume
156pub_type
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