Age-related peculiarities of adrenergic regulation of cardiac chronotropic action after I f blockage.

Abstract:

:The effects of norepinephrine on the heart rate were studied in 1-, 3-, 6-, and 20-week-old rats before and after blockade of hyperpolarization-activated currents (I f , I h ). In animals with mature sympathetic regulation of cardiac activity (6- and 20-week-old animals), I f blockage decreased the severity of norepinephrine-induced tachycardia. In newborn rats lacking sympathetic innervation of the heart, norepinephrine only slightly affected heart rate before and after I f blockage. In 3-week-old animals, I f blockage after norepinephrine pretreatment increased tachycardia.

journal_name

Bull Exp Biol Med

authors

Ziyatdinova NI,Dement'eva RE,Khisamieva LI,Zefirov TL

doi

10.1007/s10517-013-2262-6

subject

Has Abstract

pub_date

2013-11-01 00:00:00

pages

1-3

issue

1

eissn

0007-4888

issn

1573-8221

journal_volume

156

pub_type

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