Abstract：
:We studied the effect of Ladasten (30 mg/kg intraperitoneally for 5 days) on the subpopulation composition of T cells in immunocompetent organs of male C57Bl/6 mice during modeling of an anxious-depressive state (chronic zoosocial stress). Stress exposure of animals for 30 days was followed by a decrease in the relative weight of the thymus, increase in the weight of the spleen, reduction of the percentage of T cell populations, and shift in the CD4(+)/CD8(+) ratio toward cytotoxic T cells. Administration of Ladasten had a normalizing effect on the relative weights of study organs and subpopulation composition of T cells in immunocompetent organs, which returned to the control level.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Tallerova AV,Kovalenko LP,Kuznetsova OS,Durnev AD,Seredenin SBdoi
10.1007/s10517-014-2343-1subject
Has Abstractpub_date
2014-01-01 00:00:00pages
335-7issue
3eissn
0007-4888issn
1573-8221journal_volume
156pub_type
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