Abstract：
:Expression of glucocorticoid receptor protein in the hippocampus and frontal cortex of male and female rats during the 1st, 2nd, and 3rd weeks of life was studied by Western blot hybridization. In the frontal cortex, the concentration of receptor protein progressively increased from the 1st to the 3rd week of life; in females, expression of 94-kDa protein significantly surpassed that in males during the 1st week of life. In the hippocampus, expression of 94-kDa and 82-kDa proteins during the 1st week of life was higher in males. Moreover, expression of the major glucocorticoid receptor isoform (94 kDa) in this structure remained unchanged in all periods of the study in males, whereas in females it was low over the first 2 weeks of life and increased by the 3rd week. Variations in the expression of glucocorticoid receptors in the hippocampus of male and female rats coincide with changes in plasma corticosterone concentration during the early postnatal ontogeny.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Ordyan NE,Galeeva AY,Pivina SGdoi
10.1007/s10517-008-0248-6subject
Has Abstractpub_date
2008-08-01 00:00:00pages
176-9issue
2eissn
0007-4888issn
1573-8221pii
doijournal_volume
146pub_type
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journal_title：Bulletin of experimental biology and medicine
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