Abstract：
:We studied the role of carbon monoxide (CO) in the effect of P2X and P2Y receptor agonist ATP on the tone of rat aorta segments with intact endothelium. ATP (1-1000 μM) and P2X receptor agonist α,β-MeATP (100 μM) relaxed segments precontracted with phenylephrine (10 μM), while UTP (100-1000 μM) increased the amplitude of phenylephrine-induced contraction. The relaxing effect of ATP was enhanced by CORM II (100 μM), NO synthase inhibitor L-NAME, and guanylate cyclase inhibitor ODQ and attenuated by ZnPP IX (100 μM). The constrictive effect of UTP was weakened by CORM II (100 μM), but was not changed by ZnPP IX (100 μM). ZnPP IX (100 μM) weakened the relaxation response to α,β-MeATP. Thus, ATP involves the CO-dependent signaling cascade through P2X receptors.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Smagliy LV,Yartseva YO,Rydchenko VS,Birulina YG,Gusakova SV,Kovalev IV,Petrova IV,Nosarev AVdoi
10.1007/s10517-019-04527-8subject
Has Abstractpub_date
2019-07-01 00:00:00pages
363-366issue
3eissn
0007-4888issn
1573-8221pii
10.1007/s10517-019-04527-8journal_volume
167pub_type
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