Abstract：
:Rat liver was examined by transmission electron microscopy after a single intravenous injection of nanosized magnetite suspension (0.1 g (Fe(3)O(4))/kg body weight). Magnetite particles were found in Kupffer's cells and hepatocytes. Accumulation of the particles by these two cell types was different. Morphometry of magnetite-containing granules in Kupffer's cells and nanoparticle agglomerations in hepatocytes was carried out. The ultrastructure of Kupffer's cell granules was described and the mechanism of penetration of nanosized magnetite particles into the cells was suggested. Nanosized magnetite particles were not completely eliminated over 40 days after a single injection.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Mil'to IV,Sukhodolo IV,Miller AAdoi
10.1007/s10517-012-1756-ysubject
Has Abstractpub_date
2012-08-01 00:00:00pages
519-22issue
4eissn
0007-4888issn
1573-8221journal_volume
153pub_type
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