Abstract:
:The combined cytostatic effect of doxorubicin and gestagens progesterone, medroxyprogesterone acetate, mecigestone, and butagest on doxorubicin-resistant and doxorubicin-sensitive human breast cancer MCF-7 cells was studied by the MTT assay. On the 6th day of incubation progesterone, medroxyprogesterone acetate, mecigestone, and butagest in high concentrations (10(-5) M) potentiated the cytostatic action of doxorubicin in sensitive and resistant cells by 30-50%. Potentiation of the cytostatic effect produced by doxorubicin in sensitive cells is related to intrinsic cytotoxic activity of gestagens. In resistant cells these changes are associated with potentiation of the effect of doxorubicin.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Sergeev PV,Semeikin AV,Fedotcheva TA,Samoilikov RV,Kamernitskii AV,Levina IS,Rzheznikov VM,Grinenko GS,Korystov YN,Ermakova NV,Shaposhnikova VV,Shimanovskii NLdoi
10.1023/b:bebm.0000017093.04390.a3subject
Has Abstractpub_date
2003-11-01 00:00:00pages
460-3issue
5eissn
0007-4888issn
1573-8221journal_volume
136pub_type
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