Role of JAK/STAT3 Signaling in Functional Stimulation of Mesenchymal Progenitor Cells with Alkaloid Songorine.

Abstract:

:JAK/STAT signaling pathway was examined comparatively during realization of growth potential of mesenchymal progenitor cells stimulated with diterpene alkaloid songorine or fibroblast growth factor. The stimulating role of JAKs and STAT3 on the mitotic activity and differentiation of progenitor cells cultured with songorine was revealed. Under these conditions, the study demonstrated suppression of fibroblast colony formation against the background of reduced number of actively proliferating CFU-fibroblasts and a drop of differentiation index of progenitor cells induced by pan-JAKs and STAT3 inhibitors. The observed changes were in almost complete agreement with the character of functional reactions of the progenitor elements in response to blockade of JAKs and STAT3 with fibroblast growth factor. In addition, blockade of JAKs with this factor enhanced the differentiation rate of the progenitor cells.

journal_name

Bull Exp Biol Med

authors

Zyuz'kov GN,Udut EV,Miroshnichenko LA,Polyakova TY,Simanina EV,Stavrova LA,Prosekin GA,Zhdanov VV,Udut VV

doi

10.1007/s10517-018-4237-0

subject

Has Abstract

pub_date

2018-09-01 00:00:00

pages

665-668

issue

5

eissn

0007-4888

issn

1573-8221

pii

10.1007/s10517-018-4237-0

journal_volume

165

pub_type

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