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Human Vγ9/Vδ2 T cells: Innate adaptors of the immune system.

Abstract：

:Unconventional T cells are gaining center stage as important effector and regulatory cells that orchestrate innate and adaptive immune responses. Human Vγ9/Vδ2 T cells are amongst the best understood unconventional T cells, as they are easily accessible in peripheral blood, can readily be expanded and manipulated in vitro, respond to microbial infections in vivo and can be exploited for novel tumor immunotherapies. We here review findings that suggest that Vγ9/Vδ2 T cells, and possibly other unconventional human T cells, play an important role in bridging innate and adaptive immunity by promoting the activation and differentiation of various types of antigen-presenting cells (APCs) and even turning into APCs themselves, and thereby pave the way for antigen-specific effector responses and long-term immunological memory. Although the direct physiological relevance for most of these mechanisms still needs to be demonstrated in vivo, these findings may have implications for novel therapies, diagnostic tests and vaccines.

journal_name

Cell Immunol

journal_title

Cellular immunology

authors

Tyler CJ,Doherty DG,Moser B,Eberl M

doi

10.1016/j.cellimm.2015.01.008

subject

Has Abstract

pub_date

2015-07-01 00:00:00

pages

10-21

issue

1

eissn

0008-8749

issn

1090-2163

pii

S0008-8749(15)00009-X

journal_volume

296

pub_type

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