当前位置： SCI文献检索 > CELLULAR IMMUNOLOGY期刊下所有文献 > Signaling through the B cell antigen receptor regulates discrete steps in the antigen processing pathway.

Signaling through the B cell antigen receptor regulates discrete steps in the antigen processing pathway.

Abstract：

:Antigen processing in B cells is initiated by antigen binding to the surface B cell antigen receptor (BCR). The BCR is a signaling receptor which also functions to endocytose bound antigen for subsequent intracellular processing and presentation with class II molecules. Previously, using subcellular fractionation, we showed that although the surface BCR constitutively traffics from the cell surface to the class II peptide-loading compartment (IIPLC), cross-linking the BCR regulates trafficking, resulting in a more rapid movement of the BCR to the IIPLC (Song et al., 1995, J. Immunol. 155, 4255). The rate of degradation of both the BCR and the bound antigen was also accelerated following BCR cross-linking. Here we provide evidence that the effect of cross-linking the BCR on antigen processing is in part dependent on signal cascades initiated by the BCR. We show that the protein kinase inhibitors Genistein and Chelerythrine, which block BCR signaling, reduce BCR-enhanced antigen processing in a dose-dependent manner. The kinase inhibitors have a small effect on the rate of internalization of the BCR and antigen following BCR cross-linking and significantly decrease the accelerated trafficking to the IIPLC. The increased rate of degradation of the BCR and antigen induced by BCR cross-linking is also decreased by the kinase inhibitors. BCR signaling does not appear to have a global effect on intracellular membrane trafficking as cross-linking the BCR did not alter the rate of trafficking of newly synthesized class II molecules to the IIPLC. Thus, the signaling function of the BCR appears to play a significant role in regulating discrete steps in the intracellular antigen processing pathway.

journal_name

Cell Immunol

journal_title

Cellular immunology

authors

Wagle NM,Kim JH,Pierce SK

doi

10.1006/cimm.1998.1264

subject

Has Abstract

pub_date

1998-02-25 00:00:00

pages

1-11

issue

1

eissn

0008-8749

issn

1090-2163

pii

S0008-8749(98)91264-3

journal_volume

184

pub_type

杂志文章

相关文献

CELLULAR IMMUNOLOGY文献大全
  • The effects of an induced adenosine deaminase deficiency on T-cell differentiation in the rat.

    abstract：:Inherited deficiency of the enzyme adenosine deaminase (ADA) has been found in a significant proportion of patients with severe combined immunodeficiency disease and inherited defect generally characterized by a deficiency of both B and T cells. Two questions are central to understanding the pathophysiology of this di...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(85)90317-x

    authors： Barton RW

    更新日期：1985-10-15 00:00:00

  • Role of lymphokines in regulation of macrophage differentiation.

    abstract：:The regulatory mechanism of guinea pig lymphokines was investigated in regard to differentiation of myeloid cells to macrophages. The Ml-cell line, established from a myeloid leukemia of an SL-strain mouse, was induced to differentiate in vitro into mature macrophages possessing Fc receptors and the ability to phagocy...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(83)90355-6

    authors： Onozaki K,Akagawa KS,Haga S,Miura K,Hashimoto T,Tokunaga T

    更新日期：1983-02-15 00:00:00

  • Studies on the mechanism of suppression of experimental allergic encephalomyelitis induced by myelin basic protein-cell conjugates.

    abstract：:The mechanism of suppression of experimental allergic encephalomyelitis (EAE) induced in Lewis rats by pretreatment with myelin basic protein (MBP) coupled to syngeneic spleen leukocytes (SL) was examined. Studies on the kinetics of the tolerance induction showed that pretreatment with MBP-SL suppressed EAE if given 7...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(84)90159-x

    authors： McKenna RM,Carter BG,Sehon AH

    更新日期：1984-10-15 00:00:00

  • Induction of CD8+ suppressor T cells by treatment with DMBA and TPA in vitro.

    abstract：:Antigen-nonspecific CD8+ T suppressor cells, which suppressed delayed-type hypersensitivity (DTH) against sheep red blood cells in BALB/c mice, were induced by incubating spleen cells from mice treated with 7,12-dimethylbenz[a]anthracene (DMBA), a tumor initiator, with 12-O-tetradecanoylphorbol 13-acetate (TPA), a tum...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(91)90167-a

    authors： Negoro T,Iinuma F,Watanabe M

    更新日期：1991-12-01 00:00:00

  • The role of PIM kinases in human and mouse CD4+ T cell activation and inflammatory bowel disease.

    abstract：:PIM kinases are a family of three serine/threonine kinases expressed following T cell activation. Using potent selective small molecule antagonists of PIM-1/3 kinases, we demonstrate a potential role for these enzymes in naïve and effector CD4+ T cell activation. PIM-1/3 inhibition prevented CD4+ T cell proliferation ...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/j.cellimm.2011.10.011

    authors： Jackson LJ,Pheneger JA,Pheneger TJ,Davis G,Wright AD,Robinson JE,Allen S,Munson MC,Carter LL

    更新日期：2012-01-01 00:00:00

  • Veto activity of activated bone marrow does not require perforin and Fas ligand.

    abstract：:Veto cells suppress generation of CD8(+) T cell immune responses in an antigen-specific manner, with specificity dictated by antigens on the veto cell surface. Activated bone marrow (ABM) veto cells belong to the NK cell type lineage and veto by clonally deleting antigen-specific precursor cytotoxic T cell lymphocyte ...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1006/cimm.2001.1771

    authors： Chrobak P,Gress RE

    更新日期：2001-03-15 00:00:00

  • Burn injury suppresses human dermal dendritic cell and Langerhans cell function.

    abstract：:Human skin contains epidermal Langerhans cells (LCs) and dermal dendritic cells (DCs) that are key players in induction of adaptive immunity upon infection. After major burn injury, suppressed adaptive immunity has been observed in patients. Here we demonstrate that burn injury affects adaptive immunity by altering bo...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/j.cellimm.2011.01.007

    authors： van den Berg LM,de Jong MA,Witte Ld,Ulrich MM,Geijtenbeek TB

    更新日期：2011-01-01 00:00:00

  • Requirement for CD4+ T cells in the gammadelta T cell proliferative response to Daudi Burkitt's lymphoma.

    abstract：:Daudi Burkitt's lymphoma cells stimulate the proliferation of Vgamma2 Vdelta2 T cells in human peripheral blood mononuclear cells (PBMC). Transfection studies have established that the gammadelta T cell receptor is sufficient for recognition of a ligand associated with Daudi cells. Since other studies have demonstrate...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1006/cimm.1996.0289

    authors： Burns J,Lobo S,Bartholomew B

    更新日期：1996-11-25 00:00:00

  • Ability of T cell subsets and their soluble mediators to modulate the replication of Mycobacterium bovis in bovine macrophages.

    abstract：:Peripheral blood mononuclear cells (PBMCs) from cattle vaccinated with Bacillus Calmette-Guerin (BCG) were obtained and expanded in vitro by incubation with purified protein derivative. The ability of these cells to modulate the replication of virulent Mycobacterium bovis in autologous-infected macrophages was compare...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/j.cellimm.2005.01.003

    authors： Denis M,Wedlock DN,Buddle BM

    更新日期：2004-11-01 00:00:00

  • DC-expressed MHC class I single-chain trimer-based vaccines prime cytotoxic T lymphocytes against exogenous but not endogenous antigens.

    abstract：:The poor immunogenicity of many tumors can be partly explained by the inefficiency of the MHC class I peptide presentation pathway. MHC-I-based single-chain trimers (SCT) represent a new class of molecules with the potential to overcome this limitation. We here evaluated the ability of SCT presenting a melanoma antige...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/j.cellimm.2010.02.006

    authors： Ordaz ML,Larmonier N,Lybarger L

    更新日期：2010-01-01 00:00:00

  • Unique human neutrophil populations are defined by monoclonal antibody ED12F8C10.

    abstract：:A mouse IgG1 monoclonal antibody ED12F8C10 (C10) binds a constant percentage of peripheral blood neutrophils in the same individual when studied over time, defining a distinct subset of neutrophils in all normal individuals studied to date. Bone marrow studies confirm that the heterogeneity is present to the same degr...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(91)90010-9

    authors： Brown CC,Malech HL,Jacobson RJ,Shrimpton CF,Beverly PC,Segal AW,Gallin JI

    更新日期：1991-01-01 00:00:00

  • MFG-E8 inhibits Aβ-induced microglial production of cathelicidin-related antimicrobial peptide: A suitable target against Alzheimer's disease.

    abstract：:Neuroinflammation plays a pivotal role in the incidence and progression of Alzheimer's disease (AD). Cathelicidin-related antimicrobial peptide (CRAMP) is critically involved in the innate neuronal responses of chronic neuroinflammation in AD and thus plays a key role in the disease. Here, we show that Aβ42 induced mi...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/j.cellimm.2018.05.008

    authors： Xu X,Cai X,Zhu Y,He W,Wu Q,Shi X,Fang Y,Pei Z

    更新日期：2018-09-01 00:00:00

  • Cytolytic activity of murine anti-dog lymphoma monoclonal antibodies with canine effector cells and complement.

    abstract：:Peripheral blood leukocytes (PBL), nonadherent lymphocytes, and adherent monocytes separated from freshly isolated blood of 15 dogs were analyzed for their ability to mediate antibody-dependent cell-mediated cytotoxicity (ADCC) in combination with murine anti-tumor monoclonal antibodies (MAbs). Canine monocytes isolat...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(88)90194-3

    authors： Rosales C,Jeglum KA,Obrocka M,Steplewski Z

    更新日期：1988-09-01 00:00:00

  • Induction of class II MHC antigen expression on the murine placenta by 5-azacytidine correlates with fetal abortion.

    abstract：:During the gestational cycle the placental tissue does not express class II MHC antigens and whether this phenomenon is important to fetal survival has not yet been evoked. It has been reported that class II antigen expression precedes renal and cardiac graft rejection, which may also be the case in fetal abortion. In...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(90)90039-t

    authors： Athanassakis-Vassiliadis I,Galanopoulos VK,Grigoriou M,Papamatheakis J

    更新日期：1990-07-01 00:00:00

  • Sex differences and estrogen regulation of miRNAs in lupus, a prototypical autoimmune disease.

    abstract：:Unique dysregulated expression patterns of microRNAs (miRNAs) have been reported in many disease conditions including autoimmune diseases such as systemic lupus erythematosus (SLE). We have recently reported that miRNAs are differentially expressed not only between autoimmune and control mice, but also between male an...

    journal_title：Cellular immunology

    pub_type： 杂志文章,评审

    doi：10.1016/j.cellimm.2015.01.004

    authors： Khan D,Dai R,Ansar Ahmed S

    更新日期：2015-04-01 00:00:00

  • Hormonal regulation of soluble immune response suppressor (SIRS): a possible role of SIRS in the maintenance of pregnancy.

    abstract：:This study was conducted to investigate the effects of sex hormones upon the nature of soluble immune response suppressor (SIRS) produced by concanavalin A-stimulated Lyt-2+ T cells. Conventional SIRS affected IgM PFC only. However, SIRS made with progesterone (20-400 ng/ml or Prog-SIRS) suppressed IgM PFC, one-way ML...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(90)90164-m

    authors： Kita E,Hamuro A,Oku D,Nishikawa F,Yasui K,Emoto M,Katsui N,Kashiba S

    更新日期：1990-10-01 00:00:00

  • Elimination of both CD4+ and CD8+ T cells but not B cells eliminates inflammation and prolongs the survival of TGFbeta1-deficient mice.

    abstract：:Transforming growth factor beta1 (TGFbeta1) is a potent negative immunoregulatory molecule. We have previously shown that the autoimmune-mediated weaning-age lethality of Tgfb1-/- mice is reversed upon genetic combination with Scid or Rag null alleles. Here, we show that elimination of T but not B cells is sufficient ...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/j.cellimm.2005.02.004

    authors： Bommireddy R,Engle SJ,Ormsby I,Boivin GP,Babcock GF,Doetschman T

    更新日期：2004-11-01 00:00:00

  • An autoreactive T hybridoma expressing nonspecific helper activity.

    abstract：:Two functional T hybridomas were prepared by fusing BW5147 with ovalbumin (OVA)-primed splenic T blast cells. One was OVA specific for helper function requiring concanavalin A supernatant (CAS) for activity while the other, termed autoreactive, was nonspecific for helper-augmenting activity. Both required H-2d present...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(84)90371-x

    authors： Folks TM,Sell KW

    更新日期：1984-06-01 00:00:00

  • Delayed-type hypersensitivity to Babesia microti-infected erythrocytes in mice.

    abstract：:Strong delayed-type hypersensitivity (DTH) to Babesia microti was elicited when intraerythrocytic parasites (IEP) were inoculated subcutaneously into the flank of normal mice 6 to 14 days before challenge in the ipsilateral footpad with 10(8) IEP. Intraperitoneal or intravenous administration of antigen did not sensit...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(86)90289-3

    authors： Ruebush MJ,Troutman EH,Kennedy DA

    更新日期：1986-04-01 00:00:00

  • Characterisation of monoclonal antibodies to the TNF and TNF receptor families.

    abstract：:Tumour necrosis factor (TNF) family ligands and their corresponding receptors play important roles in the immune system and are involved in immune regulation such as lymphoid development, cell proliferation, differentiation, activation and death. Antibodies against these ligands and receptors together with Fc-fusion p...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/j.cellimm.2005.08.010

    authors： Ch'en PF,Xu XG,Liu XS,Liu Y,Song CJ,Screaton GR,Jin BQ,Xu XN

    更新日期：2005-07-01 00:00:00

  • FK-506 and cyclosporin A inhibit highly similar signal transduction pathways in human T lymphocytes.

    abstract：:This report compares the ability of cyclosporin A and FK-506 to inhibit human T cell activation triggered via cell surface molecules that utilize different intracellular processes. We stimulated highly purified peripheral blood T lymphocytes with mitogens (Con A and PHA), ionomycin + PMA, or monoclonal antibodies spec...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(91)90103-i

    authors： Lin CS,Boltz RC,Siekierka JJ,Sigal NH

    更新日期：1991-04-01 00:00:00

  • New disease old vaccine: Is recombinant BCG vaccine an answer for COVID-19?

    abstract：:Mycobacterium bovis BCG, a live attenuated tuberculosis vaccine offers protection against disseminated TB in children. BCG exhibits heterologous protective effects against unrelated infections and reduces infant mortality due to non-mycobacterial infections. Recent reports have suggested that BCG vaccination might hav...

    journal_title：Cellular immunology

    pub_type： 杂志文章,评审

    doi：10.1016/j.cellimm.2020.104187

    authors： Gupta PK

    更新日期：2020-10-01 00:00:00

  • Comparison of the capacity of murine and human class I MHC molecules to stimulate T cell activation.

    abstract：:The mechanism underlying the apparent differences in the capacity of murine and human class I MHC molecules to function as signal transducing structures in T cells was examined. Cross-linking murine class I MHC molecules on splenic T cells did not stimulate an increase in intracellular calcium ([Ca2+]i) and failed to ...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(92)90254-m

    authors： Gur H,Wacholtz MC,Lie WR,Lipsky PE,Geppert TD

    更新日期：1992-10-15 00:00:00

  • Up-regulation of Bcl-xL expression protects CD40-activated human B cells from Fas-mediated apoptosis.

    abstract：:CD40--CD40L interactions between resting B cells and activated T cells are essential for germinal center formation. It has been shown that CD40L can induce both Fas expression and susceptibility to Fas-mediated killing in B cells, while anti-Ig can partially rescue B cells from Fas-mediated killing. However, the intra...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1006/cimm.1996.0260

    authors： Zhang X,Li L,Choe J,Krajewski S,Reed JC,Thompson C,Choi YS

    更新日期：1996-10-10 00:00:00

  • A comparison of lysis mediated by Lyt 2+ TNP-specific cytotoxic-T-lymphocyte (CTL) lines with that mediated by rapidly internalized lymphotoxin-containing supernatant fluids: evidence for a role of soluble mediators in CTL-mediated killing.

    abstract：:A series of Lyt 2+, trinitrophenyl (TNP)-specific T-cell lines are shown to lyse 51Cr-labeled target cells in an antigen-specific, H-2-restricted fashion in a 4-hr assay. These cells also produce lymphotoxin, in addition to other factors, upon stimulation with TNP-haptenated syngeneic splenocytes. A technique for intr...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(85)90389-2

    authors： Schmid DS,Powell MB,Mahoney KA,Ruddle NH

    更新日期：1985-06-01 00:00:00

  • Expression of chemokine receptors on natural killer cells in HIV-infected individuals.

    abstract：:Chemokine receptors CCR5 and CXCR4 are of major importance in the pathogenesis of HIV-1 infection because they are co-receptors for human immunodeficiency virus (HIV) entry. We examined the frequency of CD3-CD56+CCR5+ and CD3-CD56+CXCR4+ in HIV-infected long-term slow progressors (SPs), HIV typical progressors (TPs) w...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/j.cellimm.2008.01.010

    authors： Jiang Y,Zhang Z,Diao Y,Jin X,Shi W,Geng W,Dai D,Zhang M,Han X,Liu J,Wang Y,Shang H

    更新日期：2008-01-01 00:00:00

  • Promoter anchored interaction landscape of THP-1 macrophages captures early immune response processes.

    abstract：:Macrophages are highly plastic immune cells with temporally distinct transcriptome changes upon lipopolysaccride (LPS) activation. However, to what extent transcriptome reprogramming is mediated via spatial chromatin looping is not well studied. We generated high resolution chromatin interaction maps for LPS-stimulate...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/j.cellimm.2020.104148

    authors： Pradhananga S,Spalinskas R,Poujade FA,Eriksson P,Sahlén P

    更新日期：2020-09-01 00:00:00

  • CTLA-4 and autoimmune thyroid disease: lack of influence of the A49G signal peptide polymorphism on functional recombinant human CTLA-4.

    abstract：:A single nucleotide A49G polymorphism (SNP) of CTLA-4 has been linked and associated with the autoimmune thyroid diseases (AITD) and thyroid autoantibody secretion. We have explored the functional mechanisms of CTLA-4 by means of recombinant human CTLA-4 expressed on transfected Jurkat T cells. Analysis of CTLA-4 tran...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/s0008-8749(02)00018-7

    authors： Xu Y,Graves PN,Tomer Y,Davies TF

    更新日期：2002-02-01 00:00:00

  • Characterization of human leucocytes bearing the IL-3 receptor.

    abstract：:Human leucocytes from peripheral blood and tonsil were examined for the presence of the IL-3 receptor using monoclonal antibodies directed to epitopes of the alpha and beta chains of the receptor. We found that the beta chain, common to IL-3, IL-5, and GM-CSF, was either present at low levels or not detected on the ma...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1006/cimm.1996.0049

    authors： Macardle PJ,Chen Z,Shih CY,Huang CM,Weedon H,Sun Q,Lopez AF,Zola H

    更新日期：1996-02-25 00:00:00

  • Evidence for a defective accumulation of protective T cells in old mice infected with Mycobacterium tuberculosis.

    abstract：:Mice infected with virulent Mycobacterium tuberculosis exhibit an age-related increase in susceptibility to disease. The basis of this susceptibility has previously been shown to reflect an inability of the aged host to generate protective CD4 T cells during the early course of the infection. The results of the presen...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1006/cimm.1993.1062

    authors： Orme IM,Griffin JP,Roberts AD,Ernst DN

    更新日期：1993-03-01 00:00:00