Burn injury suppresses human dermal dendritic cell and Langerhans cell function.


:Human skin contains epidermal Langerhans cells (LCs) and dermal dendritic cells (DCs) that are key players in induction of adaptive immunity upon infection. After major burn injury, suppressed adaptive immunity has been observed in patients. Here we demonstrate that burn injury affects adaptive immunity by altering both epidermal LC and dermal DC functions. We developed a human ex vivo burn injury model to study the function of DCs in thermally injured skin. No differences were observed in the capacity of both LCs and dermal DCs to migrate out of burned skin compared to unburned skin. Similarly, expression levels of co-stimulatory molecules were unaltered. Notably, we observed a strong reduction of T cell activation induced by antigen presenting cell (APC) subsets that migrated from burned skin through soluble burn factors. Further analyses demonstrated that both epidermal LCs and dermal DCs have a decreased T cell stimulatory capacity after burn injury. Restoring the T cell stimulatory capacity of DC subsets might improve tissue regeneration in patients with burn wounds.


Cell Immunol


Cellular immunology


van den Berg LM,de Jong MA,Witte Ld,Ulrich MM,Geijtenbeek TB




Has Abstract


2011-01-01 00:00:00














  • IgD receptor-mediated signal transduction in T cells.

    abstract::Upregulation of immunoglobulin D-specific receptors (IgD-R) on CD4+ T cells may facilitate their interaction with specific carbohydrate moieties uniquely associated with membrane IgD on B cells. Previous studies have shown that upregulation of IgD-R facilitates cognate T-B cell interactions by mediating bidirectional ...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Lakshmi Tamma SM,Wu Y,Toporovsky I,Lima V,Coico RF

    更新日期:2001-02-01 00:00:00

  • Immature T lymphocytes in human neonatal blood.

    abstract::Thirty-two cord blood samples taken after caesarean section or vaginal delivery and concurrent venous blood samples obtained from normal adult controls were evaluated using monoclonal antibodies. The percentage of circulating pan-T-cell+ lymphocytes was significantly lower in cord blood (46%) compared with adult contr...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Solinger AM

    更新日期:1985-04-15 00:00:00

  • The conventional CD4+ T cell response to staphylococcal enterotoxin B is modified by its superantigenic activity.

    abstract::Because of the massive cytokine response elicited by superantigen exposure, it has been suggested that superantigens may act as adjuvants to boost conventional antigen responses. However, most previous studies have shown that in vivo exposure to superantigen suppressed subsequent T cell responses. Here we analyzed the...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Wen R,Surman S,Blackman MA,Woodland DL

    更新日期:1997-03-15 00:00:00

  • Characterization of natural killer cells induced in the peritoneal exudates of mice infected with Listeria monocytogenes: a study of their tumor target specificity and their expression of murine differentiation antigens and human NK-associated antigens.

    abstract::That M1/70, a monoclonal anti-murine macrophage antibody, recognizes murine natural killer cells (NK) and that there is an increase in NK following intraperitoneal infection with live Listeria monocytogenes (LM) was previously reported. Here, LM-induced NK cells were further characterized with respect to tumor target ...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Holmberg LA,Ault KA

    更新日期:1984-11-01 00:00:00

  • Macrophage I-A/I-E expression and macrophage-stimulating lymphokines in murine lupus.

    abstract::Seeking common abnormalities in mice genetically predisposed to lupus-like autoimmune disease, we investigated (1) the ontogeny of Ia antigens (I-A/I-E) on the surfaces of resident peritoneal macrophages (rpM phi) of lupus and normal mice, (2) spontaneous and lectin-induced in vitro production of M phi-stimulating fac...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Kofler R,Schreiber RD,Dixon FJ,Theofilopoulos AN

    更新日期:1984-08-01 00:00:00

  • Analysis of T-T lymphocytes and T-accessory cell interactions using cloned T cells: MHC I restricted cloned T cells activate MHC II restricted T helper cells.

    abstract::We evaluated the role of molecules of the major histocompatibility complex (MHC) involved in the cellular interactions of two T-cell clones by testing the effect of monoclonal antibodies on the responses of the clones in vitro. The two T-cell clones used in the study are specific for minor histocompatibility antigens ...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Brückner T,Di Pauli R

    更新日期:1986-04-15 00:00:00

  • Wip 1 inhibits intestinal inflammation in inflammatory bowel disease.

    abstract::Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn's disease (CD), is a chronically intestinal autoimmune disease, the pathological mechanisms of which are not very clear. Wild type p-53 induced phosphatase 1 (Wip1), a serine/threonine protein phosphatase, has been reported to negatively reg...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Zhang Q,Zhang C,Chang F,Liang K,Yin X,Li X,Zhao K,Niu Q,Tian Z

    更新日期:2016-12-01 00:00:00

  • Ability of tolerized Th1 and Th2 clones to stimulate B cell activation and cell cycle progression.

    abstract::Tolerant and nontolerant murine Th1 and Th2 clones, specific for human gamma-globulin (HGG), were compared for their ability to promote cell cycle entry and progression by B cells in vitro. When stimulated with HGG, nontolerant Th1 and Th2 clones induced similar increases in B cell membrane MHC class II levels--a phen...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Gilbert KM,Rothermel AL,Ernst DN,Hobbs MV,Weigle WO

    更新日期:1992-06-01 00:00:00

  • Involvement of inflammatory cytokines in a delayed-type hypersensitivity reaction.

    abstract::We previously reported the amino acid sequence of the human macrophage chemotactic factor with a molecular weight of 1000 (MCF-1) was WLGREDGSE. In this study we examined the roles of MCF-1 and tumor necrosis factor (TNF) in a guinea pig delayed-type hypersensitivity (DTH) reaction. When macrophage chemotactic activit...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Higashi N,Yoshizuka N,Ohuchi A,Osawa T,Kobayashi Y

    更新日期:1995-04-01 00:00:00

  • Exposure to chemokines during maturation modulates antigen presenting cell function of mature macrophages.

    abstract::Macrophages generated with macrophage-colony stimulating factor (M-CSF) are defective in antigen presenting cell (APC) function, although they do express major histocompatibility (MHC) class II molecules, numerous accessory molecules, and intercellular adhesion molecules. In the present study, we show evidence that th...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Lee JK,Kim JK,Lee YR,Kim HS,Im SA,Kim K,Lee CK

    更新日期:2005-03-01 00:00:00

  • Evaluation of macrophage plasticity in brown and white adipose tissue.

    abstract::There are still questions about whether macrophage differentiation is predetermined or is induced in response to tissue microenvironments. C2D macrophage cells reside early in the macrophage lineage in vitro, but differentiate to a more mature phenotype after adoptive transfer to the peritoneal cavity (PEC-C2D). Since...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Ortega MT,Xie L,Mora S,Chapes SK

    更新日期:2011-01-01 00:00:00

  • Antigenic phenotype of TdT-positive cells in human peripheral blood.

    abstract::Double immunofluorescence studies for terminal deoxynucleotidyl transferase (TdT) and leucocyte surface membrane antigens have been used to characterize the small subpopulation of TdT-positive cells in human peripheral blood. The predominant antigens demonstrated were those coded for by the major histocompatibility co...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Bradstock KF,Kerr A,Bollum FJ

    更新日期:1985-02-01 00:00:00

  • Encephalitogenic T cells in the B10.PL model of experimental allergic encephalomyelitis (EAE) are of the Th-1 lymphokine subtype.

    abstract::T helper cells reactive to myelin basic protein are clearly implicated in the pathogenesis of murine EAE. We have developed a T cell line, BML-1 that (1) is reactive to the encephalitogenic amino terminal nonapeptide (1-9NAC) of MBP, (2) is I-Au restricted, and (3) induces relapsing EAE in B10.PL (H-2u) mice. Measurem...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Ando DG,Clayton J,Kono D,Urban JL,Sercarz EE

    更新日期:1989-11-01 00:00:00

  • Psychological stress is associated with altered levels of myeloid-derived suppressor cells in breast cancer patients.

    abstract::Our group has shown in a randomized clinical trial that psychological intervention to reduce stress in patients with stages II and III breast cancer led to enhanced immune function, fewer recurrences and improved overall survival. We hypothesized that patients with high levels of stress would have alterations in myelo...

    journal_title:Cellular immunology

    pub_type: 杂志文章,随机对照试验


    authors: Mundy-Bosse BL,Thornton LM,Yang HC,Andersen BL,Carson WE

    更新日期:2011-01-01 00:00:00

  • Human autologous rosette-forming cells. III. Binding of erythrocytes from different species to the T-cell receptors for autologous red blood cells.

    abstract::Spontaneous rosette formation in humans is restricted to a subpopulation of the circulating T cells. We have previously shown that the interaction between lymphocytes and autologous red blood cells (auto-RBC) is not mediated by a self-recognition mechanism, since allogeneic (allo-) RBC bind to T cells through the same...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Nalet V,Fournier C

    更新日期:1985-11-01 00:00:00

  • The role of antigen in the activation of regulatory T cells by immune B cells.

    abstract::The transfer of B cells from mice immunized with Type III pneumococcal polysaccharide (SSS-III) results in the activation of suppressor and amplifier T cells that control the magnitude of the antibody response in recipient mice, immunized subsequently with SSS-III. Prior treatment of transferred B cells with an excess...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Baker PJ,Taylor C,Fauntleroy MB,Stashak PW,Prescott B

    更新日期:1985-12-01 00:00:00

  • Evaluation of metabolic and immunological changes in streptozotocin-nicotinamide induced diabetic rats.

    abstract::Type 2 diabetes is a chronic disease with growing public health concern globally. Finding remedies to assist this health issue requires recruiting appropriate animal model for experimental studies. This study was designated to evaluate metabolic and immunologic changes in streptozotocin-nicotinamide induced diabetic r...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Mojani MS,Sarmadi VH,Vellasamy S,Sandrasaigaran P,Rahmat A,Peng LS,Ramasamy R

    更新日期:2014-05-01 00:00:00

  • Suppressive effects of soluble histocompatibility antigens on the in vitro generation of cytotoxic T cells to D-end alloantigens.

    abstract::Murine histocompatibility antigens were solubilized from the spleens and lungs of C57BL/6 (H-2b) animals with hypertonic salt (3 M KC1). Aggregate-free soluble antigens were incubated with nonadherent lymph node cells from BALB/c (H-2d) mice for 18 hr prior to their use as responder cells in the mixed-lymphocyte react...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Long PM,Sommer CV,Kong YM

    更新日期:1983-06-01 00:00:00

  • Igh-6b expression in BALB.nude mice.

    abstract::Mice that differ at Igh loci and the reagents that permit resolution of such distinctions are powerful genetic tools for studying B cell heterogeneity. In this report, IgM-allotype-specific ELISA revealed that two of three sources of mice designated as BALB.nude express the Igh-6b (IgMb) allotype characteristic of C57...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Riggs JE

    更新日期:1993-05-01 00:00:00

  • Implications of a rise in cytosolic free calcium in the activation of RAW-264 macrophages for tumor cell killing.

    abstract::The concentration of cytosolic-free calcium (Ca2+i) was determined with aequorin in RAW-264 macrophage-like cells activated in vitro for tumor cell killing with lymphokine (LK) and lipopolysaccharide (LPS). Treatments of these cells with optimal doses of stimulants, which evoked the development of cytolytic activity, ...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Gorecka-Tisera AM,Snowdowne KW,Borle AB

    更新日期:1986-07-01 00:00:00

  • FK506 and cyclosporin A each inhibit antigen-specific signaling in the T cell line 171 in the absence of a calcium signal.

    abstract::Antigen-specific signal transduction leading to IL2 induction and secretion in the T cell line 171 is augmented by association of p56lck with CD4. Although no change in cytoplasmic calcium level ([Ca2+]i) was detectable during antigen-specific signal transduction of 171-CD4+ cells, IL2 induction was inhibited by FK506...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Metcalfe S,Alexander D,Turner J

    更新日期:1994-10-01 00:00:00

  • Comparison of lymphokine secretion and responsiveness of human T cell clones isolated in IL-4 and in IL-2.

    abstract::Interleukin (IL)-4 has been shown to be secreted simultaneously with IL-2 and interferon (IFN)-gamma by the majority of CD4+ human T cell clones isolated and cultured using IL-2 as a growth factor. Moreover, IL-4 was found to be as efficient as IL-2 to promote the outgrowth of human T cell clones. In this study we hav...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Paliard X,de Vries JE,Spits H

    更新日期:1991-07-01 00:00:00

  • The appearance of eosinophil-directed chemotactic inhibitory factor in the serum of complete Freund's adjuvant-treated guinea pigs.

    abstract::When guinea pigs were treated by complete Freund's adjuvant (CFA), eosinophil-directed chemotactic inhibitory factor (ECIF) appeared in the serum of the treated animals. The inhibition of the response of eosinophils by ECIF was selective for the T cell-derived chemotactic factor, which has been isolated from DNP-ascar...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Hirashima M,Tashiro K,Hayashi H

    更新日期:1984-11-01 00:00:00

  • T cell receptor germline gene segments and HLA haplotypes control the length of the CDR3 of human T cell receptor beta chains.

    abstract::The third complementarity determining region (CDR3) is the most variable part of alpha beta T cell receptors (TCR) and represents the putative antigen contacting site. To identify parameters determining the structural diversity of the CDR3 region, the CDR3 length distributions of 66 BV-J combinations in peripheral CD4...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Kayser C,Waase I,Weyand CM,Goronzy JJ

    更新日期:1996-03-15 00:00:00

  • Whither T-suppressors: if they didn't exist would we have to invent them?

    abstract::Arriving at an understanding of the role of suppressor T-cells (regulatory T-cells, CD4(+)CD25+) depends on whether their functional repertoire is somatically selected to be anti-Self or anti-Nonself. Immunologists are ambivalent; often publications espousing opposite views share an author. Here the arguments are deta...

    journal_title:Cellular immunology

    pub_type: 杂志文章,评审


    authors: Cohn M

    更新日期:2004-02-01 00:00:00

  • The acute inflammatory process in murine lymphocytic choriomeningitis is dependent on Lyt-2+ immune T cells.

    abstract::Virus-immune spleen cells induce fatal immunopathology following adoptive transfer into adult C57B1/6J mice that have been infected with lymphocytic choriomeningitis virus (LCMV) and immunosuppressed with cyclophosphamide. This is accompanied by the development of potent cytotoxic T-lymphocyte (CTL) activity of donor ...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Dixon JE,Allan JE,Doherty PC

    更新日期:1987-06-01 00:00:00

  • Leukocyte complement: interleukin-like properties of factor Bb.

    abstract::It has been previously shown that the activated form of Factor B (Factor Bb) of the alternative pathway of complement activation stimulates monocyte spreading and killing of xenogenic erythrocytes and staphylococci. Factor Bb also stimulates lymphocyte blastogenesis in vitro, and native (uncleaved) Factor B is a major...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Hirani S,Fair DS,Papin RA,Sundsmo JS

    更新日期:1985-05-01 00:00:00

  • Enhanced engraftment of human peripheral blood lymphocytes into anti-murine interferon-gamma monoclonal antibody-treated C.B.-17-scid mice.

    abstract::To improve the engraftment of human peripheral blood lymphocytes (PBL) to severe combined immunodeficient (SCID) mice, and to elucidate the factors which prevent the PBL's survival, we treated SCID mice with mAb, which neutralizes murine IFN-gamma's ability to activate cell-mediated immunity. Compared with untreated m...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Shibata S,Asano T,Noguchi A,Kimura H,Ogura A,Naiki M,Doi K

    更新日期:1998-01-10 00:00:00

  • Cyclophosphamide-induced tolerance in fully allogeneic heart transplantation in mice.

    abstract::We have established a long-lasting heart allograft tolerance in H-2-incompatible combinations by intravenous injection of 10(8) allogeneic spleen cells followed by the administration of 200 mg/kg of cyclophosphamide (CP). When C57BL/10 mice (B10, H-2b) were primed iv with 1 x 10(8) viable spleen cells from naive BALB/...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Matsuura A,Katsuno M,Suzuki Y,Ito T,Yasuura K,Abe T,Yoshikai Y

    更新日期:1994-05-01 00:00:00

  • CCR5 has an expanded ligand-binding repertoire and is the primary receptor used by MCP-2 on activated T cells.

    abstract::CCR5 is a chemokine receptor expressed by T cells and macrophages, which also functions as the principal coreceptor for macrophage (M)-tropic HIV-1 strains to enter the host cells. In this study, we aim to better understand the ligand-binding profiles of CCR5 and the chemokine-receptor usage on leukocyte cells. We fou...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Ruffing N,Sullivan N,Sharmeen L,Sodroski J,Wu L

    更新日期:1998-11-01 00:00:00