Burn injury suppresses human dermal dendritic cell and Langerhans cell function.


:Human skin contains epidermal Langerhans cells (LCs) and dermal dendritic cells (DCs) that are key players in induction of adaptive immunity upon infection. After major burn injury, suppressed adaptive immunity has been observed in patients. Here we demonstrate that burn injury affects adaptive immunity by altering both epidermal LC and dermal DC functions. We developed a human ex vivo burn injury model to study the function of DCs in thermally injured skin. No differences were observed in the capacity of both LCs and dermal DCs to migrate out of burned skin compared to unburned skin. Similarly, expression levels of co-stimulatory molecules were unaltered. Notably, we observed a strong reduction of T cell activation induced by antigen presenting cell (APC) subsets that migrated from burned skin through soluble burn factors. Further analyses demonstrated that both epidermal LCs and dermal DCs have a decreased T cell stimulatory capacity after burn injury. Restoring the T cell stimulatory capacity of DC subsets might improve tissue regeneration in patients with burn wounds.


Cell Immunol


Cellular immunology


van den Berg LM,de Jong MA,Witte Ld,Ulrich MM,Geijtenbeek TB




Has Abstract


2011-01-01 00:00:00














  • Severe and prolonged inflammatory response to localized cowpox virus infection in footpads of C5-deficient mice: investigation of the role of host complement in poxvirus pathogenesis.

    abstract::Poxviruses are a large, complex group of highly successful pathogens that cause disease in humans and other animals. They encode several proteins postulated to be involved in the evasion of host immunity and therefore serve as excellent models for understanding virus-host interaction during the early stages of viral i...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Miller CG,Justus DE,Jayaraman S,Kotwal GJ

    更新日期:1995-05-01 00:00:00

  • Rejection of allogeneic tumor is not determined by host responses to MHC class I molecules and is mediated by CD4-CD8+ T lymphocytes that are not lytic for the tumor.

    abstract::In previous studies, the murine SaI (A/J derived, KkDd) sarcoma was transfected with the allogeneic MHC class I H-2Kb gene, and expressed high levels of H-2Kb antigen. Contrary to expectations, the tumor cells expressing the alloantigen (SKB3.1M tumor cells) were not rejected by autologous A/J mice. Because these resu...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Cole GA,Ostrand-Rosenberg S

    更新日期:1991-05-01 00:00:00

  • Endogenous activation of apoptosis in bursal lymphocytes: inhibition by phorbol esters and protein synthesis inhibitors.

    abstract::The bursa of Fabricius represents the primary immune organ where immature B cells undergo maturational changes in avian species. Isolation of bursal lymphocytes for analysis in cell culture results in the rapid endogenous activation of apoptosis. After 2 h of incubation, over 45% of the lymphocytes were shown to be un...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Compton MM,Waldrip HM

    更新日期:1998-03-15 00:00:00

  • Anti-CD3-induced anergy in cloned human Th0, Th1, and Th2 cells.

    abstract::In the mouse, activation of T cells by T cell receptor (TCR) crosslinking with anti-CD3 antibodies in the absence of a costimulatory signal induces Th1 but not Th2 cell anergy. Furthermore, anti-CD3 induces anergy of Th1- but not Th2-type lymphokine secretion in Th0 cells. This study was designed to determine whether ...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Nguyen DD,Beck L,Spiegelberg HL

    更新日期:1995-10-01 00:00:00

  • Natural killer cell activity in murine muscular dystrophy. III. NK-sensitive myoblast cells and lack of NK activity in beige/dystrophic hybrid mice.

    abstract::The NK-susceptibility of dystrophic mouse myoblast cells was investigated. Spleen cells from 8- to 10-week-old normal (+/+) and dystrophic (dy2J/dy2J) male C57BL/6J mice were fractionated on Percoll density gradients and the cells at each density interface were incubated with either 51Cr-labeled YAC-1 or myoblast cell...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Semple JW,Szewczuk MR

    更新日期:1986-06-01 00:00:00

  • Mouse embryonic cells become susceptible to CTL lysis after midgestation.

    abstract::The susceptibility of murine embryonic cells to CTL lysis has been assessed. Zona-free blastocysts were not lysed during 6 hr incubation with CTL sensitized against the embryonic genotype and remained capable of implantation and normal development in vivo as well as outgrowth in vitro. Freshly dissociated cells from p...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Croy BA,Rossant J

    更新日期:1987-02-01 00:00:00

  • Cross-linking staphylococcal enterotoxin A bound to major histocompatibility complex class I is required for TNF-alpha secretion.

    abstract::The mechanism of how superantigens function to activate cells has been linked to their ability to bind and cross-link the major histocompatibility complex class II (MHCII) molecule. Cells that lack the MHCII molecule also respond to superantigens, however, with much less efficiency. Therefore, the purpose of this stud...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Wright AD,Chapes SK

    更新日期:1999-11-01 00:00:00

  • Characterization of a low molecular weight suppressor of lymphocyte proliferation from guinea pig L2C leukemia cells.

    abstract::Conditioned medium (CM) from 24-hr culture of guinea pig L2C B lymphoblastic leukemia cells contained an inhibitor(s) of mitogen- and antigen-stimulated proliferation of syngeneic (strain 2 guinea pigs), allogeneic (Hartley guinea pigs), and xenogeneic (Balb/c mouse, NZW rabbit) lymphocytes. The proliferation of sever...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Collins DP,Cook DJ,Ricardo MJ Jr

    更新日期:1987-04-01 00:00:00

  • Characterization of calcium-activated, phospholipid-dependent protein kinase from rat serosal mast cells and RBL-1 cells.

    abstract::Evidence is presented that rat serosal mast cells and cells of the rat basophilic leukemia line, RBL-1, each contain a calcium-activated, phospholipid-dependent protein kinase. The enzymes are very similar in their activation requirements to the calcium-dependent enzymes termed protein kinase Cs in brain. The enzyme i...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Kurosawa M,Parker CW

    更新日期:1986-12-01 00:00:00

  • Lifelong exposure to dietary fish oil alters macrophage responses in Walker 256 tumor-bearing rats.

    abstract::Supplementation of the diet with fish oil (FO) decreases growth of the Walker 256 tumor and decreases the cachexia associated with tumor-bearing. The mechanisms by which FO inhibits tumor growth and cachexia are unknown. Macrophages are very important in host defence against tumors since they produce several anti-tumo...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Bonatto SJ,Folador A,Aikawa J,Yamazaki RK,Pizatto N,Oliveira HH,Vecchi R,Curi R,Calder PC,Fernandes LC

    更新日期:2004-09-01 00:00:00

  • DosR antigen Rv1737c induces activation of macrophages dependent on the TLR2 pathway.

    abstract::Latent Mycobacterium tuberculosis (Mtb) infection (LTBI) is the main clinical manifestation after Mtb exposure. During the latent phase, Mtb retards the attempts of eradication by the host immune system. The dormancy survival regulator (DosR) is held as essential for Mtb persistence. Rv1737c is predominantly expressed...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Gao X,Wu C,He W,Wang X,Li Y,Wang Y,Jia Y,Yuan R,Li H,Zhang B

    更新日期:2019-10-01 00:00:00

  • Mouse homolog of Saccharomyces cerevisiae spo11 is induced in normal mu(+)B-cells by stimuli that cause germline C(H) transcription and subsequent class switch recombination.

    abstract::The first step of Ig heavy chain class switch recombination (CSR) is considered to be DNA double strand break (DSB) formation in the two switch (S) regions (S(mu) and downstream S(H)), although the underlying mechanism is unknown. Recently, it has been demonstrated that at least Spo11, a homolog of the novel type II t...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Tokuyama H,Tokuyama Y

    更新日期:2000-05-25 00:00:00

  • Monoclonal anti-actin antibody recognizes a surface molecule on normal and transformed human B lymphocytes: expression varies with phase of cell cycle.

    abstract::A monoclonal anti-actin antibody, 2C9, was used to study the distribution of an actin-like cell-surface antigen (hereafter termed actin) on a lymphoblastoid cell line LA350 and on human peripheral blood lymphocytes. It was determined that 8-40% of LA350 cells and 3-15% of peripheral blood lymphocytes from healthy dono...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Bach MA,Lewis DE,McClure JE,Parikh N,Rosenblatt HM,Shearer WT

    更新日期:1986-04-01 00:00:00

  • Accelerated progression of Hodgkin's-like lymphomas in golli deficient SJL mice.

    abstract::Spontaneously occurring lymphomas in SJL mice have many pathological features similar to Hodgkin's lymphoma in humans. The malignant growth of the tumor cells is dependent on the support of host FoxP3(+)CD4(+) regulatory T cells (Tregs). In this study, we report that the ablation of golli protein, a negative regulator...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Ouyang S,Han G,Wu X,Jiang Z,Feng JM

    更新日期:2016-04-01 00:00:00

  • T lymphocytes and neutrophil granulocytes differ in regulatory signaling and migratory dynamics with regard to spontaneous locomotion and chemotaxis.

    abstract::Chemotactic migration of T lymphocytes and neutrophil granulocytes within a three-dimensional collagen matrix is distinct from spontaneous, matrix-induced migration concerning dynamic parameters and regulatory intracellular signaling. Both spontaneous T lymphocyte locomotion and stromal-cell-derived factor-1 (SDF-1)-i...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Entschladen F,Gunzer M,Scheuffele CM,Niggemann B,Zänker KS

    更新日期:2000-02-01 00:00:00

  • The choriocarcinoma cell line JEG-3 upregulates regulatory T cell phenotypes and modulates pro-inflammatory cytokines through HLA-G.

    abstract::An understanding of the interactions between immune cells and trophoblast cells, as well as choriocarcinoma cells, are of extreme importance in reproductive immunology and cancer immunology. In this study, we found that the human HLA-G-positive choriocarcinoma cell line JEG-3 upregulates CD4+CD25hiCD127lo T cells, inc...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Melsted WN,Matzen SH,Andersen MH,Hviid TVF

    更新日期:2018-02-01 00:00:00

  • In situ effector pathways of allograft destruction. 1. Generation of the "cellular" effector response in the graft and the graft recipient.

    abstract::Inflammatory leukocytes of DA-to-WF rat renal allografts displayed significant cytolytic activity to natural killer (NK) target cells on Day 2 after transplantation. The NK activity, which was associated with large granular lymphocytes in discontinuous Percoll gradients, peaked on Day 4 and disappeared rapidly thereaf...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Nemlander A,Soots A,Häyry P

    更新日期:1984-12-01 00:00:00

  • Correlations of programmed death 1 expression and serum IL-6 level with exhaustion of cytomegalovirus-specific T cells after allogeneic hematopoietic stem cell transplantation.

    abstract::The effect of programmed death 1 (PD-1) on cytomegalovirus (CMV)-specific T cells has not been thoroughly examined. We evaluated the involvement of exhausted CMV-specific T cells in persistent CMV infection after allogeneic hematopoietic stem cell transplantation (HSCT). CMV-specific CD8+ T cells obtained from an HLA-...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Kato T,Nishida T,Ito Y,Murase M,Murata M,Naoe T

    更新日期:2014-03-01 00:00:00

  • Immature CD4- CD8+ murine thymocytes.

    abstract::Mature thymocytes are usually defined and separated from other less mature thymocytes on the basis of their mutually exclusive expression of either CD4 or CD8. However, such murine "single positives" include a subpopulation of immature cells with properties resembling CD4- CD8- thymocytes or CD4+ CD8+ cortical blasts....

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Shortman K,Wilson A,Egerton M,Pearse M,Scollay R

    更新日期:1988-05-01 00:00:00

  • In vivo treatment with anti-ICAM-1 and anti-LFA-1 antibodies inhibits contact sensitization-induced migration of epidermal Langerhans cells to regional lymph nodes.

    abstract::Development of contact hypersensitivity in mice depends on the migration of Langerhans cells from the epidermis to regional lymph nodes. Since ICAM-1 and LFA-1 play important roles in leukocyte migration, we sought to determine whether in vivo administration of anti-ICAM-1 and anti-LFA-1 antibodies would inhibit conta...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Ma J,Wang JH,Guo YJ,Sy MS,Bigby M

    更新日期:1994-10-15 00:00:00

  • Evaluation of specificity and effects of monoclonal antibodies submitted to the Eighth Human Leucocyte Differentiation Antigen Workshop on rotavirus-cell attachment and entry.

    abstract::Rotavirus infection of permissive cells is a multi-step process that requires interaction with several cell surface receptors. Integrins alpha2beta1, alpha4beta1, alphaXbeta2, and alphavbeta3 are involved in the attachment and entry into permissive cells for many rotavirus strains. However, possible roles of known par...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Halasz P,Fleming FE,Coulson BS

    更新日期:2005-07-01 00:00:00

  • CTLA-4 and autoimmune thyroid disease: lack of influence of the A49G signal peptide polymorphism on functional recombinant human CTLA-4.

    abstract::A single nucleotide A49G polymorphism (SNP) of CTLA-4 has been linked and associated with the autoimmune thyroid diseases (AITD) and thyroid autoantibody secretion. We have explored the functional mechanisms of CTLA-4 by means of recombinant human CTLA-4 expressed on transfected Jurkat T cells. Analysis of CTLA-4 tran...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Xu Y,Graves PN,Tomer Y,Davies TF

    更新日期:2002-02-01 00:00:00

  • Beta2-integrin, LFA-1, and TCR/CD3 synergistically induce tyrosine phosphorylation of focal adhesion kinase (pp125(FAK)) in PHA-activated T cells.

    abstract::Complete T cell activation requires not only a first signal via TCR/CD3 engagement but also a costimulatory signal through accessory receptors such as CD2, CD28, or integrins. Focal adhesion kinase, pp125(FAK) (FAK), was previously shown to be localized in focal adhesions in fibroblasts and to be involved in integrin-...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Tabassam FH,Umehara H,Huang JY,Gouda S,Kono T,Okazaki T,van Seventer JM,Domae N

    更新日期:1999-05-01 00:00:00

  • γδ T cell activation by bispecific antibodies.

    abstract::Bispecific antibodies have been successfully introduced into clinical application. γδ T cells are of special interest for tumor immunotherapy, due to their recognition of pyrophosphates that are overproduced by many tumor cells resulting in HLA-nonrestricted tumor cell killing. Here we describe in detail a [(Her2)2 × ...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Oberg HH,Kellner C,Gonnermann D,Peipp M,Peters C,Sebens S,Kabelitz D,Wesch D

    更新日期:2015-07-01 00:00:00

  • Induction of unresponsiveness to Heymann's nephritis: inhibited by monoclonal antibody to CD4 but not to CD8.

    abstract::The effects of mAb therapy to CD4 or CD8 on induction of unresponsiveness to Heymann's nephritis by preimmunization with renal tubular antigen in IFA. Anti-CD4 mAbs (MRC Ox35) given for 2 weeks after RTA/IFA completely prevented the induction of resistance to HN, all rats developing proteinuria as well as high titers ...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Quiza CG,Leenaerts PL,Hall BM

    更新日期:1991-04-01 00:00:00

  • Accessory cell function in a Con A response: role of Ia and interleukin 1.

    abstract::Accessory cell (A-cell) function in a Con A response was analyzed. Irradiated P388D1 cells efficiently induced a proliferative response to Con A of T cells purified from spleen cells, whereas paraformaldehyde-fixed P388D1 cells failed to serve as A cells. Although IL-1 containing culture supernatant (SN) of a macropha...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Kohno K,Kakiuchi T,Takeuchi M,Taira S,Nariuchi H

    更新日期:1987-05-01 00:00:00

  • Costimulation by extracellular matrix proteins determines the response to TCR ligation.

    abstract::Although ligation of the T-cell antigen receptor (TCR) is central to the responsiveness and antigen specificity of T-cells, it is insufficient to elicit a response. To determine whether the need for costimulation reflects inadequate strength of signal transduction through the TCR or an absolute block of signaling in t...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Adler B,Ashkar S,Cantor H,Weber GF

    更新日期:2001-05-25 00:00:00

  • T-cell receptor gamma delta diversity and specificity of intestinal intraepithelial lymphocytes: analysis of IEL-derived hybridomas.

    abstract::The phenotype, T-cell antigen receptor (TCR) usage and specificity of intestinal intraepithelial lymphocytes (IEL), and hybridomas derived from IEL have been examined. In young conventionally reared mice, approximately 50% of the IEL express TCR alpha beta and 50% express TCR gamma delta, although there is considerabl...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Sydora BC,Mixter PF,Houlden B,Hershberg R,Levy R,Comay M,Bluestone J,Kronenberg M

    更新日期:1993-12-01 00:00:00

  • Gain-of-function mutations in CARD11 promote enhanced aggregation and idiosyncratic signalosome assembly.

    abstract::BENTA (B cell Expansion with NF-κB and T cell Anergy) is a novel lymphoproliferative disorder caused by germline, gain-of-function (GOF) mutations in the lymphocyte-restricted scaffolding protein CARD11. Similar somatic CARD11 mutations are found in lymphoid malignancies such as diffuse large B cell lymphoma (DLBCL). ...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Stinson JR,Dorjbal B,McDaniel DP,David L,Wu H,Snow AL

    更新日期:2020-07-01 00:00:00

  • Immunoregulation by natural killer cells.

    abstract::Polyinosinic-polycytidilic acid (poly (I:C], a synthetic analog of viral double-stranded RNA (dsRNA), activates natural killer (NK) cells and inhibits induction or promotes termination of the primary IgM response in vivo. Suppression of responses was reproduced in vivo by interferons (IFN) which activate NK cells and ...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Abruzzo LV,Mullen CA,Rowley DA

    更新日期:1986-04-01 00:00:00