Burn injury suppresses human dermal dendritic cell and Langerhans cell function.

abstract：:Peripheral blood lymphocytes (PBL) isolated from BALB/c mice bearing a B-cell leukemia (BCL1) showed a marked proliferative response upon two days culturing with poly(L-lysine) (PLL) of various molecular weights. An inverse relationship was noted between the molecular weight of the PLL and the dose required for optima...

journal_title：Cellular immunology

authors： Morecki S,Flechner Y,Slavin S

更新日期：1985-02-01 00:00:00

abstract：:We investigated whether sn-1,2-dioctanoylglycerol (diC8) activates highly purified human T cells. diC8's signaling activity was also compared with that of 12-O-tetradecanoylphorbol-13-acetate (TPA). diC8 and ionomycin were synergistic in promoting T-cell proliferation. The proliferative response was dependent upon an ...

journal_title：Cellular immunology

authors： Subramaniam A,Sehajpal P,Murthi VK,Stenzel KH,Suthanthiran M

更新日期：1988-10-15 00:00:00

abstract：:The effect of programmed death 1 (PD-1) on cytomegalovirus (CMV)-specific T cells has not been thoroughly examined. We evaluated the involvement of exhausted CMV-specific T cells in persistent CMV infection after allogeneic hematopoietic stem cell transplantation (HSCT). CMV-specific CD8+ T cells obtained from an HLA-...

journal_title：Cellular immunology

authors： Kato T,Nishida T,Ito Y,Murase M,Murata M,Naoe T

更新日期：2014-03-01 00:00:00

abstract：:Experimental autoimmune encephalomyelitis was induced in a Lewis rat by sensitization with synthetic peptide GP68-86, representing the 68-86 sequence of guinea pig myelin basic protein (GPMBP). To delineate T cell determinants of GP68-86, lymph node cells from this rat were activated in culture with GP68-86 and were f...

journal_title：Cellular immunology

authors： Mannie MD,Paterson PY,U'Prichard DC,Thomas DW

更新日期：1989-09-01 00:00:00

abstract：:It is suggested that autologous mixed lymphocyte reaction (AMLR) may play an important role in generating suppressor inducer signals and in down-regulating the immune response following self-major histocompatibility recognition. In the present study, monoclonal antibodies directed at cell surface structures on T4+ cel...

journal_title：Cellular immunology

authors： Takeuchi T,Schlossman SF,Morimoto C

更新日期：1987-06-01 00:00:00

abstract：:Fibroblast activation protein α (FAPα) is expressed in cancer-associated fibroblasts (CAFs), which are the main type of cells in the tumor microenvironment. CAFs exert immunosuppressive activity, which can weaken the effects of cancer immunotherapy and mainly account for poor outcomes with therapeutic vaccines. To bet...

journal_title：Cellular immunology

authors： Xia Q,Zhang FF,Geng F,Liu CL,Wang YQ,Xu P,Lu ZZ,Xie Y,Wu H,Chen Y,Zhang Y,Kong W,Yu XH,Zhang HH

更新日期：2016-12-01 00:00:00

abstract：:The systemic adoptive transfer of activated T cells, derived from tumor-draining lymph nodes (LNs), mediates the regression of established tumors. In this study, the requirement of cell adhesion molecules, CD11a/CD18 (LFA-1), CD54 (ICAM-1), CD49d/CD29 (VLA-4), and CD106 (VCAM-1), for T cell infiltration into tumors an...

journal_title：Cellular immunology

authors： Mukai S,Kagamu H,Shu S,Plautz GE

更新日期：1999-03-15 00:00:00

abstract：:The nuclear receptor Small Heterodimer Partner (SHP) is a transcriptional target and inhibitor of Liver Receptor Homolog 1 (LRH-1), the transcriptional regulator of intestinal glucocorticoid (GC) synthesis. The role of SHP in the regulation of intestinal GC synthesis and its impact on T cell-mediated anti-viral immune...

journal_title：Cellular immunology

authors： Huang J,Jia R,Brunner T

更新日期：2018-12-01 00:00:00

abstract：:Lung cancer cells harboring multiple mutations as a consequence of long-term damage by different etiologic factors are responsible for high immunogenicity. Immune checkpoint inhibitors significantly improve treatment results in non-small cell lung cancer (NSCLC). Unfortunately, the role of T-lymphocytes in early NSCLC...

journal_title：Cellular immunology

authors： Rutkowski J,Cyman M,Ślebioda T,Bemben K,Rutkowska A,Gruchała M,Kmieć Z,Pliszka A,Zaucha R

更新日期：2017-12-01 00:00:00

abstract：:Sensitized T lymphocytes can mediate potent antitumor effects when transferred to tumor-bearing animals. Employing the MCA 105 and MCA 106 sarcomas, we were able to generate antitumor effector cells by immunization of syngeneic mice with tumor cells admixed with Corynebacterium parvum. These immune splenocytes could b...

journal_title：Cellular immunology

authors： Chang AE,Perry-Lalley DM,Shu S

更新日期：1989-05-01 00:00:00

abstract：:This study examines cytotoxic mechanisms used by channel catfish peripheral blood-derived effector cells. Transmission electron microscopy (TEM), coupled with [(3)H]thymidine DNA fragmentation (JAM) and terminal deoxynucleotidyl nick-end labeling (TUNEL) assays, provided the first evidence that catfish peripheral bloo...

journal_title：Cellular immunology

authors： Hogan RJ,Taylor WR,Cuchens MA,Naftel JP,Clem LW,Miller NW,Chinchar VG

更新日期：1999-08-01 00:00:00

abstract：:Possible causes were examined for the inability of heat-inactivated lymphocytes to induce proliferative responses in mixed-lymphocyte cultures (MLC). Cells heated at 45 degrees C for 60 min lost greater than 90% of their capacity to stimulate in primary (1 degree) or secondary (2 degrees) MLC. This was not due to acce...

journal_title：Cellular immunology

authors： Boyer CM,Kostyu DD,Brissette CS,Amos DB

更新日期：1986-09-01 00:00:00

abstract：:We have previously used human Epstein Barr virus (EBV)-transformed B lymphoblastoid cell lines for the identification and purification of a novel cytokine, natural killer cell stimulatory factor (NKSF/IL-12), that has pleiotropic effects on human lymphocytes. B cell lines are also routinely employed as feeder cells fo...

journal_title：Cellular immunology

authors： Valiante NM,Rengaraju M,Trinchieri G

更新日期：1992-11-01 00:00:00

abstract：:Recombinant IL-4 inhibits IL-2-induced lymphokine-activated killer (LAK) cell development of PBMC. We evaluated the effect of various cytokines in reversing IL-4-mediated LAK inhibition. PBMC were cultured in IL-2 (10-1000 u/ml) with or without IL-4 (2-100 u/ml) and tested for cytotoxicity against the NK-sensitive K56...

journal_title：Cellular immunology

authors： Swisher SG,Economou JS,Holmes EC,Golub SH

更新日期：1990-07-01 00:00:00

abstract：:Two monoclonal antibodies specific for different rat T-cell subpopulations, the anti-helper-T-cell antibody, W3/25, and the OX8 suppressor cell antibody were used to investigate lectin-stimulated T-lymphocyte differentiation of F-344 rat bone marrow cells in culture. Cytofluorometric analysis of freshly isolated lymph...

journal_title：Cellular immunology

authors： Pfeifer RW,Stillman WS,Irons RD

更新日期：1983-12-01 00:00:00

abstract：:Exposure to pathogens induces dendritic cells to release inflammatory cytokines and chemokines. The inflammatory response is controlled by endogenous agents such as anti-inflammatory cytokines, glucocorticoids, anti-inflammatory neuropeptides, and lipid mediators. This study is the first report on the inhibition by pr...

journal_title：Cellular immunology

authors： Vassiliou E,Jing H,Ganea D

更新日期：2003-06-01 00:00:00

abstract：:Previous studies have shown that the anti-CD4 mAb W3/25 strongly enhances T cell APC (T-APC) activity. In this study, single positive CD4+ and double negative (DN) (CD4-CD8-) T-helper cells specific for the 55-69 or 72-86 sequence of guinea pig (GP) myelin basic protein (GPMBP) were used to study CD4 regulation of T-A...

journal_title：Cellular immunology

authors： Mannie MD,White GA,Nardella JP,Davidian DK,Arnold PY

更新日期：1998-06-15 00:00:00

abstract：:Activated natural killer T (NKT) cells produce a broad range of cytokines, including IL-4 and IFN-gamma, that determine immunomodulatory functions in various animal models. In this report, we show that a well-known proinflammatory cytokine, IL-17 is also produced by a distinct population of NKT cells upon TCR stimulat...

journal_title：Cellular immunology

authors： Lee KA,Kang MH,Lee YS,Kim YJ,Kim DH,Ko HJ,Kang CY

更新日期：2008-01-01 00:00:00

abstract：:Toll-like receptors are a family of pattern-recognition receptors that contribute to the innate immune response. Toll-like receptor 3 (TLR3) signals in response to foreign, endogenous and synthetic ligands including viral dsRNA, bacterial RNA, mitochondrial RNA, endogenous necrotic cell mRNA and the synthetic dsRNA an...

journal_title：Cellular immunology

authors： Duffy KE,Lamb RJ,San Mateo LR,Jordan JL,Canziani G,Brigham-Burke M,Korteweg J,Cunningham M,Beck HS,Carton J,Giles-Komar J,Duchala C,Sarisky RT,Mbow ML

更新日期：2007-08-01 00:00:00

abstract：:Many studies have shown that tumor necrosis factor (TNF) is a potent soluble mediator of immunoregulation and inflammation. Neuropeptide substance P (SP) has been known to exert significant influence on production of certain inflammatory cytokine by immune cells. Immunopathogenic mechanism underlying the effect of neu...

journal_title：Cellular immunology

authors： Nair MP,Schwartz SA

更新日期：1995-12-01 00:00:00

abstract：:Observational studies in multiple sclerosis (MS) demonstrated altered expression of chemokine receptors (CkRs) on comparable populations of mononuclear cells (e.g. CD4(+)/CD45RO(+) T-cells) in brain sections compared with blood. These findings raised questions about the regulation of CkRs on trafficking cells. Regulat...

journal_title：Cellular immunology

authors： Ubogu EE,Callahan MK,Tucky BH,Ransohoff RM

更新日期：2006-09-01 00:00:00

abstract：:Immunosuppression is a well-established risk factor for Visceral Leishmaniasis. Post-immunosuppression leishmaniasis is characterized by an increase of parasite burden, hematopoietic disorders and unusual clinical manifestations. Although there are many reports on bone marrow findings in VL, less is known about the re...

journal_title：Cellular immunology

authors： Carvalho-Gontijo R,Moreira DR,Resende M,Costa-Silva MF,Peruhype-Magalhães V,Ribeiro CMF,Ribeiro DD,Silvestre R,Cordeiro-da-Silva A,Martins-Filho OA,Teixeira-Carvalho A

更新日期：2018-04-01 00:00:00

abstract：:Supplementation of the diet with fish oil (FO) decreases growth of the Walker 256 tumor and decreases the cachexia associated with tumor-bearing. The mechanisms by which FO inhibits tumor growth and cachexia are unknown. Macrophages are very important in host defence against tumors since they produce several anti-tumo...

journal_title：Cellular immunology

authors： Bonatto SJ,Folador A,Aikawa J,Yamazaki RK,Pizatto N,Oliveira HH,Vecchi R,Curi R,Calder PC,Fernandes LC

更新日期：2004-09-01 00:00:00

abstract：:C3H/HeJ mice are homozygous for the Lpsd allele and, as a consequence, are hyporesponsive to all of the biological effects of bacterial lipopolysaccharide (LPS) that have been studied. These mice die in the early phase of infection when inoculated with virulent Salmonella. This susceptibility is also regulated by the ...

journal_title：Cellular immunology

authors： Weinstein DL,Lissner CR,Swanson RN,O'Brien AD

更新日期：1986-10-01 00:00:00

abstract：:It has been reported that granulocyte/macrophage colony-stimulating factor (GM-CSF), one of the hemopoietic growth factors which regulates the function of phagocytic cells, is a potent activator of cultured macrophages and induces antimicrobial activities as well as differentiation of precursor cells. In this study, w...

journal_title：Cellular immunology

authors： Yamamoto Y,Klein TW,Tomioka M,Friedman H

更新日期：1997-02-25 00:00:00

abstract：:In the present study, we characterized in monocytes the rise in [Ca(2+)](i) evoked by monoclonal antibodies (mAbs) to aminopeptidase N (APN)/CD13, showing a two-phase calcium increase with a small-belled [Ca(2+)](i) rise due to the release of calcium from intracellular stores and a more sustained plateau due to the in...

journal_title：Cellular immunology

authors： Santos AN,Langner J,Herrmann M,Riemann D

更新日期：2000-04-10 00:00:00

abstract：:In this study we investigated whether T cells expressing high or low levels of CD62L were differentially susceptible to the T cell chemokine lymphotactin. We found that lymphotactin induced preferential migration of antigen-specific (CD62L(lo)) T cells over the nonspecific (CD62L(hi)) T cells in vitro and in vivo. The...

journal_title：Cellular immunology

authors： Kurt RA,Bauck M,Harma S,McCulloch K,Baher A,Urba WJ

更新日期：2001-05-01 00:00:00

abstract：:Adhesion of hematopoietic cells to extracellular matrix components is important for blood cell development. However, little is known regarding the potential influence of IL-3 on this process for precursor B cells and Flt3-ligand has not yet been implicated in induction of adhesion of any blood cell types to extracellu...

journal_title：Cellular immunology

authors： Shibayama H,Anzai N,Ritchie A,Zhang S,Mantel C,Broxmeyer HE

更新日期：1998-07-10 00:00:00

abstract：:Cyclosporin A (CsA) was tested for its modulatory effects on the mIgM-mediated signaling of G0*-associated increases in class II MHC expression, G1-related RNA synthesis, and S phase-related DNA synthesis in human B cells. While CsA at concentrations as low as 10-100 ng/ml could completely ablate anti-IgM-induced DNA ...

journal_title：Cellular immunology

authors： Mongini PK,Blessinger CA,Dalton JP,Seki T

更新日期：1992-04-01 00:00:00

abstract：:The precise role of the granular enzyme A (granzyme A), a serine protease, in the lytic process of cytotoxic T lymphocytes (CTL) is not clear. We have recently constructed a CTL line transfected with the antisense gene of granzyme A (a-GrA). These a-GrA CTL had lower GrA activity as well as decreased lytic activities,...

journal_title：Cellular immunology

authors： Koo GC,Luk Y,Talento A,Wu J,Sirotina A,Fischer PA,Blake JT,Nguyen MP,Parsons W,Poe M

更新日期：1996-12-15 00:00:00