Abstract：
:C3H/HeJ mice are homozygous for the Lpsd allele and, as a consequence, are hyporesponsive to all of the biological effects of bacterial lipopolysaccharide (LPS) that have been studied. These mice die in the early phase of infection when inoculated with virulent Salmonella. This susceptibility is also regulated by the Lpsd allele. The mechanism of Lpsd-conferred Salmonella susceptibility was evaluated in these studies. The response of C3H/HeJ mice to S. typhimurium strains of differing virulence was compared in a series of in vivo experiments to the response of: endotoxin-responsive (Lpsn) mice that carry another Salmonella susceptibility gene (Itys) and endotoxin-responsive mice that carry a Salmonella resistance gene (Ityr). The C3H/HeJ mice (genotype Lpsd/Ityr) were more resistant than Lpsn/Itys mice to strains of S. typhimurium of reduced virulence but less resistant than Lpsn/Ityr mice. In addition, C3H/HeJ macrophages cultured in vitro were less able to contain net salmonellae multiplication than were macrophages from Lpsn/Ityr mice. Moreover, histopathological findings revealed that S. typhimurium-infected Lpsn/Ityr animals recruited an abnormally low number of cells into their livers compared to either Lpsn/Ityr mice or Lpsn/Itys mice. These data suggest that the susceptibility of C3H/HeJ mice may be the result of at least two Lpsd-encoded defects: a decreased capacity of macrophages to restrict Salmonella growth and a reduced recruitment of inflammatory cells into liver.
journal_name
Cell Immunoljournal_title
Cellular immunologyauthors
Weinstein DL,Lissner CR,Swanson RN,O'Brien ADdoi
10.1016/0008-8749(86)90326-6subject
Has Abstractpub_date
1986-10-01 00:00:00pages
68-77issue
1eissn
0008-8749issn
1090-2163pii
0008-8749(86)90326-6journal_volume
102pub_type
杂志文章abstract：:The mechanisms of glucocorticoid-induced immunosuppression of human monocytes for the defense of Candida albicans were examined in this in vitro study. Dexamethasone at pharmacological concentrations (10(-7)-10(-5) M) dose-dependently attenuated growth inhibition of C. albicans by resident monocytes. In interferon-gam...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1006/cimm.1994.1230
更新日期：1994-09-01 00:00:00
abstract：:Allergic asthma affects more women than men. It is mediated partially by IL-4/IL-13-driven polarization of monocyte-derived macrophages in the lung. We tested whether sex differences in asthma are due to differential IL-4 responsiveness and/or chemokine receptor expression in monocytes and monocyte-derived macrophages...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/j.cellimm.2020.104252
更新日期：2021-02-01 00:00:00
abstract：:The nuclear receptor Small Heterodimer Partner (SHP) is a transcriptional target and inhibitor of Liver Receptor Homolog 1 (LRH-1), the transcriptional regulator of intestinal glucocorticoid (GC) synthesis. The role of SHP in the regulation of intestinal GC synthesis and its impact on T cell-mediated anti-viral immune...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/j.cellimm.2018.08.009
更新日期：2018-12-01 00:00:00
abstract：:Mice carrying a rearranged TCR Vbeta 8.2 transgene express the Vbeta protein on the vast majority of peripheral T-cells. The bone marrow and peripheral blood, as well as other lymphoid organs of both untreated animals and animals depleted of T-cells by neonatal thymectomy and/or injection from birth of monoclonal anti...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1006/cimm.1997.1168
更新日期：1997-10-10 00:00:00
abstract：:In this paper, we examined the contribution of the lymphokine interleukin-6 (IL-6) to the growth of four virulent strains of Mycobacterium avium and the nature of the binding moieties on the mycobacteria. First, we showed that human or mouse recombinant interleukin-6 are potent growth factors for four strains of virul...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(92)90137-e
更新日期：1992-04-15 00:00:00
abstract：:PD-1 is an immunoregulatory receptor expressed on the surface of activated T cells, B cells, and monocytes. We describe four alternatively spliced PD-1 mRNA transcripts (PD-1Deltaex2, PD-1Deltaex3, PD-1Deltaex2,3, and PD-1Deltaex2,3,4) in addition to the full length isoform. PD-1Deltaex2 and PD-1Deltaex3 are generated...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/j.cellimm.2005.07.007
更新日期：2005-06-01 00:00:00
abstract：:The expression and function of surface immunoglobulin (sIg) receptors was analyzed using antigen-specific monoclonal B cells and T cells. When B cells were incubated with antigen (hapten carrier), hapten-specific sIg receptor expression was greatly reduced. The specific antigen-presentation activity of the B cells was...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(88)90291-2
更新日期：1988-03-01 00:00:00
abstract：:Several studies have demonstrated that addition of soluble anti-CD6 mAbs to 12-O-tetradecanoylphorbol 13-acetate (TPA)-treated naive T cells can induce cell proliferation. We showed in the present study that cell proliferation in TPA-treated T cell cultures can be enhanced several fold when the anti-CD6 mAbs are eithe...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1006/cimm.1995.0006
更新日期：1995-11-01 00:00:00
abstract：:We and other investigators have previously demonstrated that mycoplasmas induce macrophage-mediated lysis of tumor cells, but the mechanism responsible for this process had, thus far, not been clarified. We now report that addition of either viable or heat-killed Mycoplasma orale to murine macrophages induces a cytoly...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(89)90012-9
更新日期：1989-06-01 00:00:00
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journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/j.cellimm.2020.104159
更新日期：2020-09-01 00:00:00
abstract：:Spleen cells from normal, nonautoimmune mice (C3H/HeN) spontaneously produce hemolytic plaques against autologous bromelain-treated red blood cells (BrMRBC). The number of anti-BrMRBC plaques detectable can be increased by including either a 3 M KCl extracted antigen from BrMRBCs or the hapten phosphorylcholine chlori...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(86)90268-6
更新日期：1986-03-01 00:00:00
abstract：:The induction of ornithine decarboxylase (ODC) activity in lymphocytes is associated with activation and the initiation of cellular proliferation. ODC is also an essential component in tumor promotion. Phorbol myristic acetate (PMA) is a mitogen for lymphocytes, but can also promote tumor formation. Tumor promotion is...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(88)90015-9
更新日期：1988-04-15 00:00:00
abstract：:Macrophages in varying states of activation differ in their ability to perform antibody-dependent cellular cytotoxicity (ADCC) and antibody-independent macrophage-mediated tumor cytotoxicity (MTC). To define further the activation requirements for macrophages to perform various cytolytic functions, we stimulated pepto...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(91)90255-a
更新日期：1991-06-01 00:00:00
abstract：:Monocytes and macrophages link the innate and adaptive immune systems and protect the host from the outside world. In inflammatory disorders their activation leads to tissue damage. Galectins have emerged as central regulators of the immune system. However, if they regulate monocyte/macrophage physiology is still unkn...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/j.cellimm.2011.06.003
更新日期：2011-01-01 00:00:00
abstract：:Enteric immunization with schistosome ova results in a diminished granulomatous response. This study explored a mechanism by which enteric immunization may decrease granuloma size. Granulomas from livers of acutely infected mice were dissociated and the dispersed cells were depleted of macrophages. As defined by a dir...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(87)90227-9
更新日期：1987-09-01 00:00:00
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journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(85)90345-4
更新日期：1985-11-01 00:00:00
abstract：:TE44, an H-2b-restricted, self-reactive T-cell line, did not produce autocrine-acting growth factors, neither after antigenic nor after mitogenic activation; they remained for their proliferation completely dependent on exogenously added IL-2. Administration of IL-4, which poorly promotes growth by itself, resulted in...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(90)90163-l
更新日期：1990-10-01 00:00:00
abstract：:Rat IL-2 produced by spleen cells in culture with concanavalin A was purified using gel filtration, hydrophobic chromatography, and ion-exchange chromatography. At least two forms of rat IL-2 were found to be separable by ion-exchange chromatography. These two forms have been designated form I and form II. Form I of r...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(88)90251-1
更新日期：1988-06-01 00:00:00
abstract：:A decapeptide (1182-1191) derived from the bovine interphotoreceptor retinoid-binding protein (IRBP) was found to contain two completely distinct antigenic sites when tested in Lewis rats. One site, localized in sequence 1182-1191, is the core of the immunodominant and highly uveitogenic determinant of IRBP. The secon...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(92)90181-n
更新日期：1992-03-01 00:00:00
abstract：:Macrophages are key cell types of innate immunity and play a central role in inflammation and host defense. Leukocyte-associated Ig-like receptor-1 (LAIR-1) is highly expressed on macrophages and regulates macrophage functions in several conditions. However, whether LAIR-1 is involved in governing macrophage polarizat...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/j.cellimm.2018.05.011
更新日期：2018-09-01 00:00:00
abstract：:Recently, it has been reported that IL-4 production by murine Th2 cell lines is insensitive to inhibition by E-type prostaglandins. In the present study, IL-4 production in vitro by freshly isolated concanavalin A (Con A)-stimulated murine spleen cells was readily suppressed by PGE2 with an I50 of 2 nM. Comparable sup...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(95)80039-l
更新日期：1995-02-01 00:00:00
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journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1006/cimm.1996.0029
更新日期：1996-02-01 00:00:00
abstract：:In this study we assessed the viability of cultured human umbilical vein endothelial cells (HUVE) treated with bacterial lipopolysaccharide (LPS), recombinant human interleukin-1 (rhIL-1), or recombinant human tumor necrosis factor-alpha (rhTNF-alpha) during inhibition of RNA or protein synthesis. Cytotoxicity was det...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(89)90222-0
更新日期：1989-03-01 00:00:00
abstract：:This study addresses the nature of the pathogenic effector T cell in experimental autoimmune uveoretinitis and the effect of different cytokines on these cells in vitro. Lymph node cells of B10.RIII mice immunized with the uveitogenic peptide 161-180 of interphotoreceptor retinoid binding protein were cultured with th...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1006/cimm.1997.1121
更新日期：1997-05-25 00:00:00
abstract：:Our strategy to use saturation mutagenesis to produce an unbiased collection of major histocompatibility class I mutants has resulted in unpredicted mutant phenotypes. First, we have shown data supporting our earlier work of the Dp20(Y27N) mutant. Allorecognition is altered at the clonal level while no variation in ly...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(90)90020-r
更新日期：1990-06-01 00:00:00
abstract：:Mycobacterial antigens including BCG stimulate human peripheral blood mononuclear cells resulting in cellular proliferation and the release of inflammatory cytokines such as TNF-alpha. However, the signal transduction mechanisms responsible for the BCG-induced cell activation are not completely understood. In this stu...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1006/cimm.1996.0185
更新日期：1996-07-10 00:00:00
abstract：:Normal spleen cells cultured in high or low concentrations of interleukin (IL) 2 for 3 days contain Thy-1+ CD4- CD8+ cells that powerfully suppress primary but not ongoing or active lymphocyte responses. The precursors of these cells are Thy-1+ AGM-1- and are absent or present in greatly diminished numbers in athymic ...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(89)90111-1
更新日期：1989-11-01 00:00:00
abstract：:Theiler's murine encephalomyelitis virus-induced demyelinating disease (TMEV-IDD), a model for multiple sclerosis, is a chronic T cell-mediated disease. Development of clinical symptoms in susceptible mouse strains generally correlates with TMEV-specific delayed-type hypersensitivity (DTH) responses. These responses, ...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1006/cimm.1993.1303
更新日期：1993-12-01 00:00:00
abstract：:Enriched human B lymphocytes cocultivated with mouse L cells produced human leukocyte interferon (IFN-alpha) and shortly thereafter transferred antiviral activity to the recipient cells (99% inhibition of expected virus yield). In contrast, cocultivation of enriched T-cell populations with mouse L cells resulted in no...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(84)90035-2
更新日期：1984-09-01 00:00:00
abstract：:A previous report (G. E. Woloschak and D. Senitzer, submitted for publication) has demonstrated that mitogen-stimulated splenocytes fuse at a much higher frequency than untreated splenocytes as measured by the fusion index (a calculation of the number of nuclei in fused cells vs the total number of nuclei). A measurem...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(83)90059-x
更新日期：1983-07-01 00:00:00
