Local synthesis of immunosuppressive glucocorticoids in the intestinal epithelium regulates anti-viral immune responses.

abstract：:To understand the role of cAMP during macrophage activation, we investigated the effects of various cAMP analogues in the induction of nitric oxide (NO) synthesis in murine peritoneal macrophages. Intracellular cAMP modulators such as N6,O2'-dibutyryl cyclic AMP (DB-cAMP), 8-bromo-cAMP, or 8-chloro-cAMP had no effect ...

journal_title：Cellular immunology

authors： Park YC,Park SJ,Jun CD,Kim GE,Park KI,Kim HD,Park RK,Chung HT

更新日期：1997-07-10 00:00:00

abstract：:Previous results have shown that in addition to their ability to kill tumor cell lines, peripheral blood leukocytes (PBL) expanded in interleukin 2 (IL-2) can also destroy normal PBL targets. Cold target competition results show that PBL and tumor cells can be destroyed by the same population of IL-2-expanded leukocyt...

journal_title：Cellular immunology

authors： Chen BP,Malkovsky M,Hank JA,Sondel PM

更新日期：1987-12-01 00:00:00

abstract：:As fascinating a molecule as it can potentially get, nuclear factor-κB (NF-κB), a regulatory transcription factor, is as intriguing. NF-κB is a dimeric complex that controls the transcription of essential genes. NF-κB is involved in a variety of responses that play a pivotal role in regulating the immune response to i...

journal_title：Cellular immunology

authors： Haddad JJ,Abdel-Karim NE

更新日期：2011-01-01 00:00:00

abstract：:The expression of HLA Class II antigens by resting and phytohemagglutinin (PHA)-activated T cells and their functional properties in autologous mixed-lymphocyte reactions (MLR) were investigated in patients with chronic active hepatitis, with alcoholic cirrhosis, and with primary biliary cirrhosis. In all groups of pa...

journal_title：Cellular immunology

authors： Scudeletti M,Indiveri F,Pierri I,Picciotto A,Ferrone S

更新日期：1986-10-01 00:00:00

abstract：:Mycobacterial antigens including BCG stimulate human peripheral blood mononuclear cells resulting in cellular proliferation and the release of inflammatory cytokines such as TNF-alpha. However, the signal transduction mechanisms responsible for the BCG-induced cell activation are not completely understood. In this stu...

journal_title：Cellular immunology

authors： Méndez-Samperio P,Hernandez-Garay M,Vazquez AN

更新日期：1996-07-10 00:00:00

abstract：:Autoimmune regulator (Aire) is a transcriptional activator that regulates the ectopic expression of many tissue-restricted antigens in medullary thymic epithelial cells, and that has an important role in the negative selection of autoreactive T cells. However, the roles of Aire expression in peripheral lymphoid tissue...

journal_title：Cellular immunology

authors： Zhu W,Yang W,He Z,Liao X,Wu J,Sun J,Yang Y,Li Y

更新日期：2011-01-01 00:00:00

abstract：:Transforming growth factor beta1 (TGFbeta1) is a potent negative immunoregulatory molecule. We have previously shown that the autoimmune-mediated weaning-age lethality of Tgfb1-/- mice is reversed upon genetic combination with Scid or Rag null alleles. Here, we show that elimination of T but not B cells is sufficient ...

journal_title：Cellular immunology

authors： Bommireddy R,Engle SJ,Ormsby I,Boivin GP,Babcock GF,Doetschman T

更新日期：2004-11-01 00:00:00

abstract：:Receptors for the Fc domain of IgG mediate target recognition, signal transduction, and effector functions including antibody-dependent cytolysis, phagocytosis, and phagolysosome formation. To better understand FcR-mediated functions and to identify potential therapeutic strategies, we employed cell-penetrating ("Troj...

journal_title：Cellular immunology

authors： Clark AJ,Petty HR

更新日期：2010-01-01 00:00:00

abstract：:Short-term culture of murine lymphocytes in interleukin 2 (IL-2), in the absence of any priming antigen, has been shown to result in the differentiation of an activated killer cell population capable of potent cytotoxic activity against tumor cells. The progenitor and lineage of these lymphokine activated killer cells...

journal_title：Cellular immunology

authors： Owen-Schaub LB,Abraham SR,Hemstreet GP 3rd

更新日期：1986-12-01 00:00:00

abstract：:We evaluated the role of molecules of the major histocompatibility complex (MHC) involved in the cellular interactions of two T-cell clones by testing the effect of monoclonal antibodies on the responses of the clones in vitro. The two T-cell clones used in the study are specific for minor histocompatibility antigens ...

journal_title：Cellular immunology

authors： Brückner T,Di Pauli R

更新日期：1986-04-15 00:00:00

abstract：:Neuroendocrine hormones such as growth hormone (GH) and prolactin (PRL) have been demonstrated to accelerate the recovery of the immune response after chemotherapy and bone marrow transplantation and to enhance the restoration of immunity in individuals infected with HIV and in normal individuals with compromised immu...

journal_title：Cellular immunology

authors： Redelman D,Welniak LA,Taub D,Murphy WJ

更新日期：2008-03-01 00:00:00

abstract：:Previous investigations have demonstrated a strain-associated differential susceptibility to herpes simplex virus-1 (HSV-1) infection in mice; C57BL/6 mice are more resistant to infection than BALB/c mice. Despite considerable research dealing with the immune response to HSV-1, relatively little attention has been pai...

journal_title：Cellular immunology

authors： Brenner GJ,Cohen N,Moynihan JA

更新日期：1994-09-01 00:00:00

abstract：:The first step of Ig heavy chain class switch recombination (CSR) is considered to be DNA double strand break (DSB) formation in the two switch (S) regions (S(mu) and downstream S(H)), although the underlying mechanism is unknown. Recently, it has been demonstrated that at least Spo11, a homolog of the novel type II t...

journal_title：Cellular immunology

authors： Tokuyama H,Tokuyama Y

更新日期：2000-05-25 00:00:00

abstract：:Murine peritoneal macrophages (M phi), activated in vivo or in vitro, remarkably inhibited the uptake of thymidine by a lens epithelial cell line, while resident M phi, or M phi induced by thioglycollate, exhibited much lower or no cytostatic capacity. The target cells were partially protected from the cytostatic acti...

journal_title：Cellular immunology

authors： Mochizuki M,Zigler JS Jr,Russell P,Gery I

更新日期：1984-01-01 00:00:00

abstract：:Poxviruses are a large, complex group of highly successful pathogens that cause disease in humans and other animals. They encode several proteins postulated to be involved in the evasion of host immunity and therefore serve as excellent models for understanding virus-host interaction during the early stages of viral i...

journal_title：Cellular immunology

authors： Miller CG,Justus DE,Jayaraman S,Kotwal GJ

更新日期：1995-05-01 00:00:00

abstract：:During ultrastructural studies of the early kinetics of anaphylactic degranulation and early and late recovery intervals from these release reactions induced in isolated, partially purified, cultured human lung mast cells stimulated to release histamine and granules by exposure to anti-IgE, we noted the ability of mas...

journal_title：Cellular immunology

authors： Dvorak AM,Schleimer RP,Lichtenstein LM

更新日期：1987-03-01 00:00:00

abstract：:Polyunsaturated fatty acid [omega-3 polyunsaturated fatty acids (omega-3PUFAs)] incorporation into cell membranes has been shown to have potent anti-inflammatory activity, though the mechanisms involved are only partially characterized. Here, we show that PUFA enrichment of T cell membranes decreased the overall expre...

journal_title：Cellular immunology

authors： Leid JG,Jutila MA

更新日期：2004-04-01 00:00:00

abstract：:The CD2 (T11) molecule belongs to a family of cell-surface glycoproteins that function as adhesion molecules in the immune system. Human CD2 is found exclusively on cells of the T lineage: peripheral T lymphocytes, NK cells, and thymocytes. CD2 binds specifically to the surface glycoprotein LFA-3. CD2/LFA-3 adhesion i...

journal_title：Cellular immunology

authors： Rabin EM,Gordon K,Knoppers MH,Luther MA,Neidhardt EA,Flynn JF,Sardonini CA,Sampo TM,Concino MF,Recny MA

更新日期：1993-06-01 00:00:00

abstract：:This study was designed to investigate the regulatory role of soluble interleukin-6 receptor (sIL-6R) and interleukin-6 (IL-6) fusion protein (Hyper-IL-6) in the differentiation of human myeloid and erythroid progenitors by a serum-free liquid suspension culture system, using the human cord blood-derived CD34(+)CD38(-...

journal_title：Cellular immunology

authors： Yu Z,Liu W,Liu D,Fan L

更新日期：2006-05-01 00:00:00

abstract：:BST2 is a type II transmembrane protein that had been initially identified as a surface molecule expressed on terminally differentiated B cells. Here, we characterize the expression of BST2 in human endothelial cells, HUVECs. IFN-γ, among various inflammatory stimuli, dramatically upregulates BST2 expression in HUVECs...

journal_title：Cellular immunology

authors： Yoo H,Park SH,Ye SK,Kim M

更新日期：2011-01-01 00:00:00

abstract：:The effects of LTs are mediated by GPCRs: cysLTs interact with CYSLTR1, CYSLTR2, or GPR17, and LTB4 acts via BLT1R or BLT2R. Data relating to the presence of these receptors in mature tissue mast cells are not entirely known. By confocal microscopy with image analyses and flow cytometry, we established that native rat...

journal_title：Cellular immunology

authors： Agier J,Różalska S,Wódz K,Brzezińska-Błaszczyk E

更新日期：2017-07-01 00:00:00

abstract：:A series of anti-DNA antibody-producing hybridomas were obtained by fusing spleen cells from 6-month-old MRL/lpr, autoimmune prone, mice with P3X63-Ag8 myeloma cells. Rabbit anti-idiotype (id) antibodies specific for several of the hybridoma proteins were prepared. It was shown that the anti-id antibody inhibited immu...

journal_title：Cellular immunology

authors： Kim YT,Puntillo E,DeBlasio T,Weksler ME,Siskind GW

更新日期：1987-03-01 00:00:00

abstract：:The antimicrobial peptide LL-37 is known to have a potent LPS-neutralizing activity in monocytes and macrophages. Recently, LL-37 in gingival crevicular fluids is suggested to be the major protective factor preventing infection of periodontogenic pathogens. In this study, we tried to address the effect of LL-37 on pro...

journal_title：Cellular immunology

authors： Into T,Inomata M,Shibata K,Murakami Y

更新日期：2010-01-01 00:00:00

abstract：:We investigated the time course of the 17 beta-estradiol effect on mouse natural killer (NK) activity and the number of splenic large granular lymphocytes (LGL), a cell population recently associated with natural cytotoxicity and enriched in low density fractions of Percoll discontinuous density gradients. After 7 day...

journal_title：Cellular immunology

authors： Screpanti I,Santoni A,Gulino A,Herberman RB,Frati L

更新日期：1987-05-01 00:00:00

abstract：:The in vitro effect of single or combined doses of zidovudine (AZT) and dideoxycytidine (ddC) on the production and utilization of interleukin-2 (IL-2) by normal human peripheral blood mononuclear cells (PBMC) was evaluated by measuring IL-2 concentrations in supernatants from PHA-stimulated PBMC cultures. Drugs were ...

journal_title：Cellular immunology

authors： Viora M,Camponeschi B

更新日期：1995-07-01 00:00:00

abstract：:Dipeptidyl peptidase IV (DP IV, CD26), known as an activation marker of T lymphocytes, is a proline-specific protease thought to be involved in the regulation of the immune response. The physiological role of dipeptidyl peptidase IV in the immune system and the molecular events of lymphocyte activation mediated by thi...

journal_title：Cellular immunology

authors： Kähne T,Kröning H,Thiel U,Ulmer AJ,Flad HD,Ansorge S

更新日期：1996-05-25 00:00:00

abstract：:Although ligation of the T-cell antigen receptor (TCR) is central to the responsiveness and antigen specificity of T-cells, it is insufficient to elicit a response. To determine whether the need for costimulation reflects inadequate strength of signal transduction through the TCR or an absolute block of signaling in t...

journal_title：Cellular immunology

authors： Adler B,Ashkar S,Cantor H,Weber GF

更新日期：2001-05-25 00:00:00

abstract：:We have compared the interaction of Mycobacterium tuberculosis with the human macrophage-like cell line THP-1 and with human monocyte-derived macrophages (MDM). The association of M. tuberculosis with THP-1 and MDM was comparable in both the presence and the absence of serum. For both cells, serum-mediated binding was...

journal_title：Cellular immunology

authors： Stokes RW,Doxsee D

更新日期：1999-10-10 00:00:00

abstract：:Strong delayed-type hypersensitivity (DTH) to Babesia microti was elicited when intraerythrocytic parasites (IEP) were inoculated subcutaneously into the flank of normal mice 6 to 14 days before challenge in the ipsilateral footpad with 10(8) IEP. Intraperitoneal or intravenous administration of antigen did not sensit...

journal_title：Cellular immunology

authors： Ruebush MJ,Troutman EH,Kennedy DA

更新日期：1986-04-01 00:00:00

abstract：:Possible causes were examined for the inability of heat-inactivated lymphocytes to induce proliferative responses in mixed-lymphocyte cultures (MLC). Cells heated at 45 degrees C for 60 min lost greater than 90% of their capacity to stimulate in primary (1 degree) or secondary (2 degrees) MLC. This was not due to acce...

journal_title：Cellular immunology

authors： Boyer CM,Kostyu DD,Brissette CS,Amos DB

更新日期：1986-09-01 00:00:00