Mouse homolog of Saccharomyces cerevisiae spo11 is induced in normal mu(+)B-cells by stimuli that cause germline C(H) transcription and subsequent class switch recombination.

abstract：:The primary function of the thymus is to develop immature T-cells into cells that further in the periphery will be able to carry out immune functions. The Literature has shown that thymus can be a target for many pathogens and severe structural alterations take place in this organ during infectious diseases. Here, we ...

journal_title：Cellular immunology

authors： Andrade CF,Gameiro J,Nagib PR,Carvalho BO,Talaisys RL,Costa FT,Verinaud L

更新日期：2008-05-01 00:00:00

abstract：:The cellular requirements for stimulating primed alloreactive T cells have been investigated. In vitro-primed secondary alloreactive cells, long-term lines, and Ly 1+2- noncytolytic clones which reacted with allo-H-2K, D, or Mls (M locus) antigens were tested. The data indicated that a specialized antigen-presenting c...

journal_title：Cellular immunology

authors： Sunshine GH,Mitchell TJ,Czitrom AA,Edwards S,Glasebrook AL,Kelso A,MacDonald HR

更新日期：1985-03-01 00:00:00

abstract：:Human mononuclear cells stimulated with soluble IgG aggregates generated chemiluminescence, a response attributable to monocytes. Some requirements of this reaction were examined by preincubation of the cells with a variety of inhibitors. The protease antagonists TPCK and TLCK, the phospholipase inhibitors quinacrine ...

journal_title：Cellular immunology

authors： Rush DN,Keown PA

更新日期：1984-08-01 00:00:00

abstract：:Although it is known that IGF-1 increases T lymphocyte proliferation, the regulation of its receptor expression during the process has not been defined. Consequently the regulation of IGF-1R expression by IGF-1 and the activation events in human blood T lymphocytes and the Jurkat T cell line were now investigated. IGF...

journal_title：Cellular immunology

authors： Schillaci R,Brocardo MG,Galeano A,Roldán A

更新日期：1998-02-01 00:00:00

abstract：:Several studies have demonstrated that addition of soluble anti-CD6 mAbs to 12-O-tetradecanoylphorbol 13-acetate (TPA)-treated naive T cells can induce cell proliferation. We showed in the present study that cell proliferation in TPA-treated T cell cultures can be enhanced several fold when the anti-CD6 mAbs are eithe...

journal_title：Cellular immunology

authors： Osorio LM,Ordonez C,Garcia CA,Jondal M,Chow SC

更新日期：1995-11-01 00:00:00

abstract：:Although it is well known that the CD3/T-cell receptor (TCR) complex modulates from the surface of T cells upon exposure to monoclonal antibodies (mAb) directed against it, the fate of bound mAb has not been yet elucidated. We therefore perform direct binding experiments of 125I-labeled mAb against CD3 or TCR to inves...

journal_title：Cellular immunology

authors： Schaffar L,Dallanegra A,Breittmayer JP,Carrel S,Fehlmann M

更新日期：1988-10-01 00:00:00

abstract：:The role of macrophages (M phi) in the in vitro primary antibody response of murine lymphocytes to sheep erythrocytes was investigated. Peritoneal M phi were activated to express Ia antigens either in vitro or in vivo. Nonactivated Ia- M phi were also examined. We observed that only Ia- M phi but also Ia+ M phi failed...

journal_title：Cellular immunology

authors： Komatsubara S,Hirayama Y,Inaba K,Naito K,Yoshida K,Kawai J,Muramatsu S

更新日期：1985-10-15 00:00:00

abstract：:G proteins are membrane-bound molecules involved in coupling of surface receptors with signal transduction effector systems in multiple cell types including T lymphocytes. Given that mature T cells which lack antigen receptors (CDl-Ti) are refractory to stimulation through CD2 or other accessory molecules, T cell rece...

journal_title：Cellular immunology

authors： Moingeon P,Jin YJ,Stebbins CC,Lopez PA,Alcover A,Reinherz EL

更新日期：1990-07-01 00:00:00

abstract：:B-1a cells represent a distinct B cell population with unique phenotype, self-renewing capacity and restricted Igμ repertoire. They primarily locate in body cavity and also exist in spleen. The different subpopulations of B-1a cells are heavily affected by local environment. Our previous studies revealed that MARVEL-d...

journal_title：Cellular immunology

authors： Liu Z,Liu Y,Li T,Wang P,Mo X,Lv P,Ma D,Han W

更新日期：2020-06-01 00:00:00

abstract：:Al adjuvants are used in vaccines to increase the immune response. NTPDase and AChE play a pivotal role and act in the regulation of the immune system. The effect of Al exposure in vitro and in vivo on NTPDase and AChE activities in the lymphocytes of rats was determined. In vitro, ATP hydrolysis was decreased by 20.4...

journal_title：Cellular immunology

authors： Kaizer RR,Gutierres JM,Schmatz R,Spanevello RM,Morsch VM,Schetinger MR,Rocha JB

更新日期：2010-01-01 00:00:00

abstract：:The mechanism of suppression of experimental allergic encephalomyelitis (EAE) induced in Lewis rats by pretreatment with myelin basic protein (MBP) coupled to syngeneic spleen leukocytes (SL) was examined. Studies on the kinetics of the tolerance induction showed that pretreatment with MBP-SL suppressed EAE if given 7...

journal_title：Cellular immunology

authors： McKenna RM,Carter BG,Sehon AH

更新日期：1984-10-15 00:00:00

abstract：:This study addresses the nature of the pathogenic effector T cell in experimental autoimmune uveoretinitis and the effect of different cytokines on these cells in vitro. Lymph node cells of B10.RIII mice immunized with the uveitogenic peptide 161-180 of interphotoreceptor retinoid binding protein were cultured with th...

journal_title：Cellular immunology

authors： Xu H,Rizzo LV,Silver PB,Caspi RR

更新日期：1997-05-25 00:00:00

abstract：:The mechanism of human peripheral blood monocyte-mediated cytotoxicity was investigated using the HT-29 human colon adenocarcinoma line, A673 human rhabdomyosarcoma line, and A375 human melanoma line as target cells. Pretreatment of these target cells with 100 U/ml of recombinant human interferon (IFN)-gamma for 48 hr...

journal_title：Cellular immunology

authors： Feinman R,Siegel DS,Le JM,Vilcek J

更新日期：1986-04-15 00:00:00

abstract：:A radioautographic immunolabeling technique has been developed to detect pre-B cells bearing cytoplasmic mu chains among populations of bone marrow lymphoid cells identified by conventional hematologic stains. 125I-Anti-mu antibody was applied either to fixed marrow smears, labeling total mu chains both in the cytopla...

journal_title：Cellular immunology

authors： Rahal MD,Osmond DG

更新日期：1984-09-01 00:00:00

abstract：:Neuroendocrine hormones such as growth hormone (GH) and prolactin (PRL) have been demonstrated to accelerate the recovery of the immune response after chemotherapy and bone marrow transplantation and to enhance the restoration of immunity in individuals infected with HIV and in normal individuals with compromised immu...

journal_title：Cellular immunology

authors： Redelman D,Welniak LA,Taub D,Murphy WJ

更新日期：2008-03-01 00:00:00

abstract：:The hematopoietically restricted member of the NF-kappaB/Rel family, c-Rel, is essential for B cell survival and proliferation. Here we demonstrate that the production of the interleukins 6, 10, and 15 (IL-6, IL-10, and IL-15) are diminished in c-Rel(-/-) B lymphocytes. In a manner similar to that seen in IL-6(-/-) B ...

journal_title：Cellular immunology

authors： Tumang JR,Hsia CY,Tian W,Bromberg JF,Liou HC

更新日期：2002-05-01 00:00:00

abstract：:The cytokine interleukin 6 (IL-6) has been shown to have multiple biological activities against many cellular targets. The present studies were designed to determine whether these activities extended to the neutrophil (PMN). Initially, we investigated the ability of IL-6 to modulate PMN-mediated antibody-dependent cel...

journal_title：Cellular immunology

authors： Borish L,Rosenbaum R,Albury L,Clark S

更新日期：1989-07-01 00:00:00

abstract：:Patients treated with monoclonal antibodies and cytokines for cancer receive often co-medication, which may influence treatment efficacy. Therefore, we investigated with a flowcytometric cytotoxicity assay the effect of several immunomodulatory drugs on antibody dependent cellular cytotoxicity (ADCC), interleukin-2 (I...

journal_title：Cellular immunology

authors： Flieger D,Varvenne M,Kleinschmidt R,Schmidt-Wolf IG

更新日期：2007-03-01 00:00:00

abstract：:The 4F2 antigenic complex is expressed on most human cell lines in culture, on monocytes and activated lymphocytes, but not on resting T and B lymphocytes. Monoclonal antibody (mAb) CB43 recognizes an epitope of the 4F2 heterodimer either located on the light chain or dependent on the conformation of the molecule. The...

journal_title：Cellular immunology

authors： Spagnoli GC,Ausiello C,Palma C,Bellone G,Ippoliti G,Letarte M,Malavasi F

更新日期：1991-08-01 00:00:00

abstract：:Tiazofurin treatment of K562 leukemia cells in vitro depletes the metabolites of the guanylate biosynthetic pathway, inducing erythroid differentiation, that, in turn, alters the phenotypic profile. As a consequence, K562 cells possibly modify their interaction with immune cells. Here we describe the binding and killi...

journal_title：Cellular immunology

authors： Zamai L,Zauli G,Bavelloni A,Marmiroli S,Cataldi A,Weber G,Vitale M

更新日期：1995-08-01 00:00:00

abstract：:Although pulmonary inflammation is a serious, sometimes life-threatening, consequence of respiratory syncytial virus (RSV) infection, the mechanisms involved are not well understood. Since the process of inflammation is initiated by a complex series of events including the activation of specific adhesion molecules on ...

journal_title：Cellular immunology

authors： Chang CH,Huang Y,Anderson R

更新日期：2003-01-01 00:00:00

abstract：:MHC class II-restricted antigen presentation requires trafficking of newly synthesized class II-invariant chain complexes from the trans-Golgi network to endosomal, peptide-loading compartments. This transport is mediated by dileucine-like motifs within the cytosolic tail of the invariant chain. Although these signals...

journal_title：Cellular immunology

authors： Sevilla LM,Richter SS,Miller J

更新日期：2001-06-15 00:00:00

abstract：:Five thiol compounds including 2-mercaptoethanol (2-ME) were examined for their augmenting effects on in vitro antibody response to sheep erythrocytes. Three compounds were effective with the following order of activity; 2-ME greater than dithiothreitol greater than cysteamine. Glutathione and thioglycollate failed to...

journal_title：Cellular immunology

authors： Ohmori H,Yamamoto I

更新日期：1983-07-01 00:00:00

abstract：:In this study we have examined the cellular and molecular specificity of lymphocyte interaction with fibroblasts. Using mitogen-activated T-cells, we found that attachment to fibroblasts was highly sensitive to protease treatment, and to an antibody raised against the purified lymphocyte plasma membrane, but it was no...

journal_title：Cellular immunology

authors： Abraham D,Bou-Gharios G,Muir H,Olsen I

更新日期：1989-08-01 00:00:00

abstract：:CD48, the murine homolog of human CD58, binds to CD2 in rats and mice. Whereas inhibition of CD2 signaling leads to profound immunosuppression, no information is available on CD48-targeted therapy in the rat. We could show that anti-CD2 treatment (OX34) efficiently inhibited TCR-driven as well as CD2-mediated prolifer...

journal_title：Cellular immunology

authors： Sido B,Otto G,Zimmermann R,Müller P,Meuer SC,Dengler TJ

更新日期：1997-11-25 00:00:00

abstract：:This report compares the ability of cyclosporin A and FK-506 to inhibit human T cell activation triggered via cell surface molecules that utilize different intracellular processes. We stimulated highly purified peripheral blood T lymphocytes with mitogens (Con A and PHA), ionomycin + PMA, or monoclonal antibodies spec...

journal_title：Cellular immunology

authors： Lin CS,Boltz RC,Siekierka JJ,Sigal NH

更新日期：1991-04-01 00:00:00

abstract：:Although CD4(+)CD25(+) regulatory T cells are pivotal in the suppression of autoimmunity, little is known about the effect of antigen-specific regulatory T cells on the formation of atheromatous plaques. Here, we describe the induction of heat-shock protein 60 (HSP60)-specific CD4(+)CD25(high) T cells by rapamycin (RP...

journal_title：Cellular immunology

authors： Yang K,Li D,Luo M,Hu Y

更新日期：2006-10-01 00:00:00

abstract：:The activation by concanavalin A (Con A) of murine lymphocytes derived from aged animals is impaired, as demonstrated by lower IL-2 synthesis, display of fewer IL-2 receptors, and less [3H]thymidine incorporation relative to similarly treated cells from young animals. The ability of the phorbol ester, phorbol 12-myris...

journal_title：Cellular immunology

authors： Thoman ML,Weigle WO

更新日期：1988-06-01 00:00:00

abstract：:A majority (42/62) of TCR2+ interleukin 2-dependent human T lymphocyte clones was found concordantly to express not only the CD28 co-receptor structure at the cell surface but also its ligand B7. Interactions between CD28 and B7 can have important consequences for T cell activation, particularly in providing "signal 2...

journal_title：Cellular immunology

authors： Friccius H,Siegels-Hübenthal P,Rehbein A,Schlotz E,Pawelec G

更新日期：1993-10-15 00:00:00

abstract：:We investigated the role of HLA-DR molecules in T cell stimulation by staphylococcal enterotoxin A (SEA). Previous results with immobilized purified HLA-DR preincubated with peptide showed that peptide-specific T cell clones were able to bind to and proliferate in response to purified HLA-DR/peptide complexes in the a...

journal_title：Cellular immunology

authors： Rust CJ,Koning F,van Schooten WC

更新日期：1993-10-15 00:00:00