Tiazofurin induces a down-modulation of ICAM-1 expression on K562 target cells impairing NK adhesion and killing.

abstract：:Murine 4-1BB is an approximately 30-kDa glycoprotein expressed on activated T cells and plays a role in T-cell-mediated proliferative response. To date the majority of work on 4-1BB has been conducted in the mouse. To assess the role of 4-1BB in humans, mAbs were made against the recombinant human (rh) 4-1BB protein. ...

journal_title：Cellular immunology

authors： Garni-Wagner BA,Lee ZH,Kim YJ,Wilde C,Kang CY,Kwon BS

更新日期：1996-04-10 00:00:00

abstract：:It is becoming increasingly clear that regulatory T cells (Treg cells) in specific tissues are important parts of immune system. Tissue-resident Treg cells, which are largely Foxp3-expressing CD4(+) Treg cells, are distinct from one another and conventional Treg cells, and have tissue-specific phenotype and function. ...

journal_title：Cellular immunology

authors： Lu J,Meng H,Zhang A,Yang J,Zhang X

更新日期：2015-09-01 00:00:00

abstract：:In mammals, macrophages (MF) are present in virtually all tissues where they serve many different functions linked primarily to the maintenance of homeostasis, innate defense against pathogens, tissue repair and metabolism. Although some of these functions appear common to all tissues, others are specific to the homin...

journal_title：Cellular immunology

authors： Wagner C,Bonnardel J,Da Silva C,Martens L,Gorvel JP,Lelouard H

更新日期：2018-08-01 00:00:00

abstract：:We compared TLR responsiveness in PBMC from HIV-1-infected and uninfected individuals using the TLR agonists: TLR7 (3M-001), TLR8 (3M-002), and TLR7/8 (3M-011). Activation and maturation of plasmacytoid dendritic cells (pDC) were measured by evaluating CD86, CD40, and CD83 expression and myeloid dendritic cell (mDC) a...

journal_title：Cellular immunology

authors： Martinson JA,Roman-Gonzalez A,Tenorio AR,Montoya CJ,Gichinga CN,Rugeles MT,Tomai M,Krieg AM,Ghanekar S,Baum LL,Landay AL

更新日期：2007-11-01 00:00:00

abstract：:Spleen cells from normal, nonautoimmune mice (C3H/HeN) spontaneously produce hemolytic plaques against autologous bromelain-treated red blood cells (BrMRBC). The number of anti-BrMRBC plaques detectable can be increased by including either a 3 M KCl extracted antigen from BrMRBCs or the hapten phosphorylcholine chlori...

journal_title：Cellular immunology

authors： Wieties KM,Moticka EJ

更新日期：1986-03-01 00:00:00

abstract：:We examined the effects of the inhibitors of C1q or collagen biosynthesis, 2,2'-dipyridyl (DP), and 3,4-dehydro-DL-proline (DHP) on murine macrophage (M phi) FcR subclass-mediated antibody-dependent cellular cytotoxicity (ADCC) and phagocytosis of sheep erythrocyte targets. Oil-elicited peritoneal M phi from C3HeB/FeJ...

journal_title：Cellular immunology

authors： Mocharla R,Mocharla H,Leu RW

更新日期：1987-03-01 00:00:00

abstract：:Our strategy to use saturation mutagenesis to produce an unbiased collection of major histocompatibility class I mutants has resulted in unpredicted mutant phenotypes. First, we have shown data supporting our earlier work of the Dp20(Y27N) mutant. Allorecognition is altered at the clonal level while no variation in ly...

journal_title：Cellular immunology

authors： Murray R,Katoh K,Alexander J,Muller D,Pederson K,Frelinger JA

更新日期：1990-06-01 00:00:00

abstract：:Interleukin-1 (IL-1) and tumor necrosis factor-alpha (TNF-alpha) are major proinflammatory cytokines inducing the synthesis and release of many inflammatory mediators. They are involved in immune regulation, autoimmune diseases, and inflammation. Acanthoic acid, (-)-pimara-9(11),15-dien-19-oic acid, is a pimaradiene d...

journal_title：Cellular immunology

authors： Kang HS,Kim YH,Lee CS,Lee JJ,Choi I,Pyun KH

更新日期：1996-06-15 00:00:00

abstract：:Vitamin D regulates homeostasis, anti-microbial response, and inflammation. The vitamin D receptors are expressed in the macrophages and other immune cells, regulating the transcription of many different genes, including those coding the anti-microbial peptides. One of the most severe complications of the SARS-CoV-2 i...

journal_title：Cellular immunology

authors： Kloc M,Ghobrial RM,Lipińska-Opałka A,Wawrzyniak A,Zdanowski R,Kalicki B,Kubiak JZ

更新日期：2021-02-01 00:00:00

abstract：:To investigate the process of tolerance induction we have developed an in vivo model using TCR beta-chain transgenic mice tolerized with the superantigen staphylococcal enterotoxin B. We have previously demonstrated that tolerized peripheral T cells were anergic when stimulated in vitro with immunogenic peptides, supe...

journal_title：Cellular immunology

authors： Perkins DL,Listman JA,Wang Y,Ho SS,Finn PW,Rimm IJ

更新日期：1994-07-01 00:00:00

abstract：:Tolerant and nontolerant murine Th1 and Th2 clones, specific for human gamma-globulin (HGG), were compared for their ability to promote cell cycle entry and progression by B cells in vitro. When stimulated with HGG, nontolerant Th1 and Th2 clones induced similar increases in B cell membrane MHC class II levels--a phen...

journal_title：Cellular immunology

authors： Gilbert KM,Rothermel AL,Ernst DN,Hobbs MV,Weigle WO

更新日期：1992-06-01 00:00:00

abstract：:Several lines of evidence suggest that nitric oxide (NO), generated through nitric oxide synthase (NOS) by cleavage of terminal guanidino nitrogen from L-arginine, mediates tumor cell killing by mononuclear phagocytes. Natural killer (NK) cells are cytotoxic effector cells that lyse a variety of tumor and virus-infect...

journal_title：Cellular immunology

authors： Cifone MG,Festuccia C,Cironi L,Cavallo G,Chessa MA,Pensa V,Tubaro E,Santoni A

更新日期：1994-08-01 00:00:00

abstract：:With old age (∼2y old), mice show substantial differences in B cell composition within the lymphoid tissues. In particular, a novel subset of IgM+ CD21/35lo/- CD23- mature B cells, the age-associated B cells or ABC, increases numerically and proportionately. This occurs at the expense of other B cell subsets, includin...

journal_title：Cellular immunology

authors： Riley RL,Khomtchouk K,Blomberg BB

更新日期：2017-11-01 00:00:00

abstract：:In view of the eminently important role of interleukin-2 (IL-2) in T-cell responses, and in view of reports about immune stimulatory effects of PGE2, we reinvestigated the question whether PGE2 inhibits IL-2 production. It was found that PGE2 does not inhibit IL-2 production in murine spleen cell cultures after optima...

journal_title：Cellular immunology

authors： Wolf M,Falk W,Männel D,Dröge W

更新日期：1985-01-01 00:00:00

abstract：:The role of macrophages (M phi) and that of splenic dendritic cells (DC) in the allogeneic mixed leukocyte reaction (MLR) in the mouse have been investigated. In contrast with the high stimulatory capacity of DC, we obtained no evidence in favor of the competence of M phi, whether Ia + or Ia-, as an autonomous stimula...

journal_title：Cellular immunology

authors： Naito K,Komatsubara S,Kawai J,Mori K,Muramatsu S

更新日期：1984-10-15 00:00:00

abstract：:We have analyzed the effect of cyclosporin-A (CsA) on the proliferative and cytotoxic responses induced by mixed-lymphocyte cultures (MLC-s) on low and high density T lymphocytes. Allogeneic stimulation had a different impact on the two subsets. Proliferative and cytotoxic responses were inversely correlated; i.e., hi...

journal_title：Cellular immunology

authors： Bejarano MT,Masucci MG,Klein E

更新日期：1986-12-01 00:00:00

abstract：:The immediate effects and mechanisms of desensitization of contact sensitivity to 2,4-dinitro-1-fluorobenzene (DNFB) were investigated. Mice were sensitized with DNFB, desensitized with antigen 2 weeks later, and challenged 1 day after desensitization. Significant inhibition (approximately 50%) of contact sensitivity ...

journal_title：Cellular immunology

authors： Mekori YA,Claman HN

更新日期：1984-11-01 00:00:00

abstract：:Chemokine receptors CCR5 and CXCR4 are of major importance in the pathogenesis of HIV-1 infection because they are co-receptors for human immunodeficiency virus (HIV) entry. We examined the frequency of CD3-CD56+CCR5+ and CD3-CD56+CXCR4+ in HIV-infected long-term slow progressors (SPs), HIV typical progressors (TPs) w...

journal_title：Cellular immunology

authors： Jiang Y,Zhang Z,Diao Y,Jin X,Shi W,Geng W,Dai D,Zhang M,Han X,Liu J,Wang Y,Shang H

更新日期：2008-01-01 00:00:00

abstract：:Varying the concentration of anti-CD3 immobilized on Sepharose beads allowed us to study both the inhibitory and the stimulatory effects of IL-4 on purified T cells and contrast IL-4 versus IL-2-driven T-cell proliferative responses. In the presence of low density immobilized anti-CD3, IL-4 was unable to stimulate pur...

journal_title：Cellular immunology

authors： Jones-Tiffany LA,Mehrotra PT,Horohov DW,Siegel J,Kozak RW

更新日期：1993-04-01 00:00:00

abstract：:Activated macrophages synthesize and release numerous tumoricidal soluble factors that can be divided into receptor- or nonreceptor-dependent agents. Tumor necrosis factor (TNF) would be an example of the former. In our experimental model the killing of EL4 thymoma cells by syngeneic activated macrophages involves, bu...

journal_title：Cellular immunology

authors： Fishman M,Essani N,Costlow M

更新日期：1990-04-15 00:00:00

abstract：:We studied the effect of vasoactive intestinal peptide (VIP), somatostatin (SOM), and substance P (SP) on IL-4-stimulated human IgE and IgG subclass production. VIP and SOM, but not SP, inhibited IgE production without affecting IgM or IgA production by mononuclear cells (MNC) from nonatopic donors from 10 pM to 10 nM...

journal_title：Cellular immunology

authors： Kimata H,Yoshida A,Ishioka C,Mikawa H

更新日期：1992-10-15 00:00:00

abstract：:Human peripheral blood cells enriched for B lymphocytes were stimulated to focal proliferation in semisolid cultures with lymphocyte-conditioned media, Protein A (Prot A), lipopolysaccharide (LPS) and 2-mercaptoethanol (2-ME). After 6-8 days of incubation, two morphologically distinct colony types were observed. Type ...

journal_title：Cellular immunology

authors： Peschel C,Gattringer C,Konwalinka G,Geissler D,Boyd J,Huber H,Braunsteiner H

更新日期：1984-10-01 00:00:00

abstract：:Cultures of gradient-purified human peripheral blood mononuclear cells (PBMC) have been employed to examine the effects of three bacteria-derived human leukocyte interferon subtypes on certain aspects of in vitro immune responses. The addition of highly purified IFN-alpha 1, -alpha 2, -alpha 2/alpha 1 to PMBC cultures...

journal_title：Cellular immunology

authors： Shalaby MR,Weck PK

更新日期：1983-12-01 00:00:00

abstract：:In this study, skin-infiltrating cells were prepared from guinea pig delayed-type hypersensitivity reaction sites, and their phenotypic properties and cytokine production were examined. Our cell preparations contained around 45% nonspecific esterase-positive cells and a few skin-derived cells. Skin-infiltrating cells ...

journal_title：Cellular immunology

authors： Higashi N,Yoshizuka N,Kobayashi Y

更新日期：1995-08-01 00:00:00

abstract：:We investigated the regulation of IL6 biological activity, de novo synthesis, and mRNA levels in adult vascular endothelial cells (EC) by bacterial endotoxin or inflammatory cytokines. Cells incubated without stimulus released scant IL6 activity. IFN gamma, IL2, or PDGF did not augment IL6 release from EC. LPS, lipid ...

journal_title：Cellular immunology

authors： Loppnow H,Libby P

更新日期：1989-09-01 00:00:00

abstract：:We have recently demonstrated that estrogen has differential immunomodulatory properties in mice because it stimulates antibody responses but inhibits T cell-mediated inflammation. In the present study we have examined the influence of estrogen on T cell-independent inflammatory responses. A local inflammation was ind...

journal_title：Cellular immunology

authors： Josefsson E,Tarkowski A,Carlsten H

更新日期：1992-06-01 00:00:00

abstract：:Experimental autoimmune thyroiditis is induced in mice by immunization with thyroglobulin emulsified in Freund's complete adjuvant. The disease is characterized both by thyroid infiltration with mononuclear cells and by circulating thyroglobulin antibodies. The magnitude of the thyroid infiltration and the titer of th...

journal_title：Cellular immunology

authors： Vladutiu AO,Steinman L

更新日期：1987-10-01 00:00:00

abstract：:Within lymphopenic recipients, naïve T cells undergo proliferation that is induced by homeostatic mechanisms. Earlier studies have demonstrated that commensal antigens play a key role in inducing the proliferation. However, a relative contribution of endogenous self antigens in this process has not been formally inves...

journal_title：Cellular immunology

authors： Do JS,Foucras G,Kamada N,Schenk AF,Shaw M,Nuñez G,Paul WE,Min B

更新日期：2012-01-01 00:00:00

abstract：:The allogeneic mixed lymphocyte reaction (MLR) is regarded as an effective model for examining the events which occur during an allospecific immune response. Numerous studies have delineated the role of adherence molecule interactions during the MLR response. In the present study we have identified VCAM-1 as having a ...

journal_title：Cellular immunology

authors： Lukacs NW,Strieter RM,Evanoff HL,Burdick MD,Kunkel SL

更新日期：1994-03-01 00:00:00

abstract：:IgA nephropathy (IgAN) is a tonsil-related disease. We previously showed that oligodeoxynucleotides with CpG (CpG-ODN) and B-cell activation factor (BAFF) are involved in hyperproduction of IgA from tonsillar mononuclear cells of patients with IgAN (IgAN-TMCs). In this study, we focused on a proliferation-inducing lig...

journal_title：Cellular immunology

authors： Takahara M,Nagato T,Nozaki Y,Kumai T,Katada A,Hayashi T,Harabuchi Y

更新日期：2019-07-01 00:00:00