Phenotype and function of tissue-resident unconventional Foxp3-expressing CD4(+) regulatory T cells.

abstract：:CD40--CD40L interactions between resting B cells and activated T cells are essential for germinal center formation. It has been shown that CD40L can induce both Fas expression and susceptibility to Fas-mediated killing in B cells, while anti-Ig can partially rescue B cells from Fas-mediated killing. However, the intra...

journal_title：Cellular immunology

authors： Zhang X,Li L,Choe J,Krajewski S,Reed JC,Thompson C,Choi YS

更新日期：1996-10-10 00:00:00

abstract：:The lineage of lymphokine-activated killer (LAK) cells is poorly understood. To examine the relationship between LAK and natural killer (NK) cells we utilized two congenitally immunodeficient mice, namely severe combined immunodeficient (scid) and athymic (nude) mice that lack T cells but have normal NK cells. LAK act...

journal_title：Cellular immunology

authors： Hasui M,Saikawa Y,Miura M,Takano N,Ueno Y,Yachie A,Miyawaki T,Taniguchi N

更新日期：1989-04-15 00:00:00

abstract：:Histidine-proline-rich glycoprotein (HPRG) is a plasma protein which binds to a specific receptor on T-lymphocytes and represses T-cell activation and proliferation. In the presence of Concanavalin A (Con A), HPRG causes human T-lymphoblastic MOLT-3 cells and a fraction of normal human peripheral blood lymphocytes to ...

journal_title：Cellular immunology

authors： Lamb-Wharton RJ,Morgan WT

更新日期：1993-12-01 00:00:00

abstract：:Our previous studies show that growth hormone overexpression (GHo) upregulates the expression of the IGF-1R and IGF-2R resulting in the protection of the EL4 lymphoma cell line from apoptosis. In this study, we report that GHo also increases TGF-beta1 protein expression measured by luciferase promoter assay, Western a...

journal_title：Cellular immunology

authors： Farmer JT,Weigent DA

更新日期：2006-03-01 00:00:00

abstract：:The fine specificity of anti-Glu60Ala30Tyr10 (GAT) and anti-Glu60Ala40 (GA) proliferating cells was studied. T cells primed with GAT proliferate both to GAT and GA and GA-primed T cells proliferate also to GA and GAT. This cross-reactivity was unexpected given the results previously reported on the fine specificity of...

journal_title：Cellular immunology

authors： Gougeon ML,Bismuth G,Leclercq L,Somme G,Thèze J

更新日期：1983-01-01 00:00:00

abstract：:Mice infected with murine acquired immunodeficiency syndrome (MAIDS) virus developed lymphoadenopathy and profound immunodeficiency. Concomitantly the expression of endogenous mammary tumor virus (MTV) mRNA increased significantly, especially for the 1.7-kb 3' open reading frame (ORF) mRNA encoding MTV superantigen. B...

journal_title：Cellular immunology

authors： Gayama S,Doyon L,Vaupel B,Sekaly RP,Kanagawa O

更新日期：1998-08-01 00:00:00

abstract：:Two signals are required for the in vitro activation of Lyt2+ T suppressor cells (Ts) from mice tolerized with 2,4-dinitrobenzene sulfonate (DNBS) to produce soluble suppressor factors (SSF) which suppress the transfer of contact sensitivity to dinitrofluorobenzene (DNFB). Recognition of DNP/class I MHC (signal one) s...

journal_title：Cellular immunology

authors： Fairchild RL,Moorhead JW

更新日期：1991-03-01 00:00:00

abstract：:T lymphocytes respond to mitogenic stimulation by expressing the receptor for interleukin 2 (Il-2) and secreting Il-2; once the receptor is expressed, Il-2 induces these cells to proliferation. In the present report using mouse T lymphocytes, thymocytes, and the lymphoma cell line EL4, we studied receptor expression a...

journal_title：Cellular immunology

authors： Truneh A,Simon P,Schmitt-Verhulst AM

更新日期：1986-12-01 00:00:00

abstract：:The Lyt phenotype of cytotoxic T cells generated in the primary H-2 response was investigated kinetically. The cytotoxicity generated in the early stage of culture was abolished by treatment with alpha Lyt-1,2,3, and complement (C), whereas that generated in the late stage was only partially eliminated by alpha Lyt-1,...

journal_title：Cellular immunology

authors： Nakayama E,Uenaka A

更新日期：1984-08-01 00:00:00

abstract：:NK and extrathymic T cells are abundant in the decidua of the pregnant uterus. To determine how this unique pattern is induced, overall populations of leukocytes were examined in the blood and other tissues in pregnant women. Time-kinetic studies showed that a basal change of leukocytes during pregnancy was granulocyt...

journal_title：Cellular immunology

authors： Minagawa M,Narita J,Tada T,Maruyama S,Shimizu T,Bannai M,Oya H,Hatakeyama K,Abo T

更新日期：1999-08-25 00:00:00

abstract：:The kinetic and the H-2 requirements for the induction of nucleoside-specific suppression were examined in several strains of mice; specifically, whether adenosine (A)-coupled spleen cells given intravenously suppress the primary response to adenosine-KLH. The adenosine system was chosen because C57Bl/6 mice were orig...

journal_title：Cellular immunology

authors： Giroir BP,Raps EC,Cookson E,Borel Y

更新日期：1983-02-01 00:00:00

abstract：:This paper investigates the presence of HLA class I-restricted and tumor-specific cytotoxic T lymphocytes (CTL) in tumor sites of esophageal cancers. Five CTL lines were established from the metastatic lymph nodes or pleural effusion by incubation with interleukin-2 of tumor-infiltrating lymphocytes: cases 1 and 5, HL...

journal_title：Cellular immunology

authors： Toh U,Yamana H,Nakao M,Imai Y,Seki N,Takasu H,Kaneshige T,Fujita H,Shirouzu K,Itoh K

更新日期：1997-05-01 00:00:00

abstract：:To determine whether human antibody responses to T cell-independent pneumococcal polysaccharide antigens are derived from CD5+ or CD5- B cells, we utilized an ELISPOT assay to detect individual anti-polysaccharide antibody-secreting cells. Human anti-type IV pneumococcal polysaccharide antibody-secreting cells were fo...

journal_title：Cellular immunology

authors： Barrett DJ,Sleasman JW,Schatz DA,Steinitz M

更新日期：1992-08-01 00:00:00

abstract：:In this study we assessed the viability of cultured human umbilical vein endothelial cells (HUVE) treated with bacterial lipopolysaccharide (LPS), recombinant human interleukin-1 (rhIL-1), or recombinant human tumor necrosis factor-alpha (rhTNF-alpha) during inhibition of RNA or protein synthesis. Cytotoxicity was det...

journal_title：Cellular immunology

authors： Pohlman TH,Harlan JM

更新日期：1989-03-01 00:00:00

abstract：:Prevention of ultraviolet radiation- or chemical carcinogen-induced morphologic transformation and inhibition of tumor-producing transformed cell growth by lymphotoxin and by normal spleen leukocytes were quantitatively compared to define the antineoplastic activity spectra of these natural immune mediators. When Syri...

journal_title：Cellular immunology

authors： Evans CH,Heinbaugh JA,DiPaolo JA

更新日期：1983-03-01 00:00:00

abstract：:The expression of HLA Class II antigens by resting and phytohemagglutinin (PHA)-activated T cells and their functional properties in autologous mixed-lymphocyte reactions (MLR) were investigated in patients with chronic active hepatitis, with alcoholic cirrhosis, and with primary biliary cirrhosis. In all groups of pa...

journal_title：Cellular immunology

authors： Scudeletti M,Indiveri F,Pierri I,Picciotto A,Ferrone S

更新日期：1986-10-01 00:00:00

abstract：:The knowledge of mechanisms of regulation of IL-10 production by B cells remains still very limited. We show here that highly purified mouse B cells stimulated with LPS produce significant levels of IL-10, but Bregs in our model do not express detectable level of either Foxp3 or GATA-3. Nevertheless, IL-10 production ...

journal_title：Cellular immunology

authors： Bohacova P,Kossl J,Hajkova M,Hermankova B,Javorkova E,Zajicova A,Krulova M,Holan V

更新日期：2020-01-01 00:00:00

abstract：:We investigated the regulation of IL6 biological activity, de novo synthesis, and mRNA levels in adult vascular endothelial cells (EC) by bacterial endotoxin or inflammatory cytokines. Cells incubated without stimulus released scant IL6 activity. IFN gamma, IL2, or PDGF did not augment IL6 release from EC. LPS, lipid ...

journal_title：Cellular immunology

authors： Loppnow H,Libby P

更新日期：1989-09-01 00:00:00

abstract：:It is still a matter of debate, whether tolerance toward self-non-MHC antigens is due to intrathymic deletion or to regulatory processes in the periphery. To further pursue this question, responsiveness toward TNP and an anti-TNP monoclonal antibody (Sp6) carrying a recurrent idiotype was evaluated in prenatally trini...

journal_title：Cellular immunology

authors： Zöller M

更新日期：1990-03-01 00:00:00

abstract：:Murine histocompatibility antigens were solubilized from the spleens and lungs of C57BL/6 (H-2b) animals with hypertonic salt (3 M KC1). Aggregate-free soluble antigens were incubated with nonadherent lymph node cells from BALB/c (H-2d) mice for 18 hr prior to their use as responder cells in the mixed-lymphocyte react...

journal_title：Cellular immunology

authors： Long PM,Sommer CV,Kong YM

更新日期：1983-06-01 00:00:00

abstract：:The activities of the enzymes involved in purine nucleoside metabolism, adenosine deaminase (ADA), adenosine kinase (AK), purine nucleoside phosphorylase (PNP) and deoxycytidine kinase (deoxyCRK), were determined in mouse thymocytes at various stages of differentiation and maturation, and compared with those in other ...

journal_title：Cellular immunology

authors： Kizaki H,Habu S,Ohsaka F,Sakurada T

更新日期：1983-12-01 00:00:00

abstract：:Blockade of the immune cell checkpoint inhibitors programmed death 1 (PD-1) and programmed death-ligand 1 (PD-L1) has become a powerful tool in cancer treatment, which is effective across various solid cancer types and hematologic malignancies. Our previous studies showed that by reducing immune tolerance, clustered r...

journal_title：Cellular immunology

authors： Shao J,Xu Q,Su S,Meng F,Zou Z,Chen F,Du J,Qian X,Liu B

更新日期：2017-10-01 00:00:00

abstract：:Normal spleen cells cultured in high or low concentrations of interleukin (IL) 2 for 3 days contain Thy-1+ CD4- CD8+ cells that powerfully suppress primary but not ongoing or active lymphocyte responses. The precursors of these cells are Thy-1+ AGM-1- and are absent or present in greatly diminished numbers in athymic ...

journal_title：Cellular immunology

authors： Torre-Amione G,Tuetken R,Rowley DA

更新日期：1989-11-01 00:00:00

abstract：:We tested the contribution of four staphylococcal components - PSM-α, PSM-β, δ-toxin, and PVL - in triggering macrophage secretion of tumor necrosis factor (TNF) and interleukins 6 (IL-6) and 12 (IL-12) by two prominent, circulating strains of community-associated, methicillin-resistant Staphylococcus aureus (CA-MRSA)...

journal_title：Cellular immunology

authors： Spentzas T,Kudumula R,Acuna C,Talati AJ,Ingram KC,Savorgnan F,Meals EA,English BK

更新日期：2011-01-01 00:00:00

abstract：:The mechanism of polyclonal B cell activation in autoimmune diseases was investigated by using an autoreactive B cell clone established by somatic hybridization with B cells derived from NZB X NZW (B/W) F1 mice. Briefly, splenic B cells from B/W F1 mice were fused with M12.4.1, a mutant of a B cell line, in the presen...

journal_title：Cellular immunology

authors： Iwasaki T,Hamano T,Hase K,Murata Y,Yamasaki T,Kakishita E

更新日期：1992-02-01 00:00:00

abstract：OBJECTIVES:Piperine, a main component of Piper species, is a plant alkaloid with a long history of medical use in a variety of inflammatory disorders like rheumatoid arthritis. Due to side effects in current treatment modalities of rheumatoid arthritis, the interest in alternative, well tolerated anti-inflammatory reme...

journal_title：Cellular immunology

authors： Umar S,Golam Sarwar AH,Umar K,Ahmad N,Sajad M,Ahmad S,Katiyar CK,Khan HA

更新日期：2013-07-01 00:00:00

abstract：:Cytokines are soluble proteins that mediate immune reactions and are responsible for communication among immune cells. CD4(+) T cells are the principle sources of cytokines of adaptive immunity. Cytokines play critical roles in the differentiation and effector function of CD4(+) T cells. They also play key roles in di...

journal_title：Cellular immunology

authors： Guo X,Zhang Y,Wang P,Li T,Fu W,Mo X,Shi T,Zhang Z,Chen Y,Ma D,Han W

更新日期：2012-07-01 00:00:00

abstract：:T-Cell hybridomas were constructed by fusing BW5147, an AKR lymphoma, with concanavalin A-stimulated murine splenic lymphocytes. The hybrids which were formed were studied for their ability to produce a lymphokine which inhibits tumor cell migration (TMIF) as well as macrophage migration (MIF) using in vitro assays. C...

journal_title：Cellular immunology

authors： Cohen MC,Lazarus M

更新日期：1985-07-01 00:00:00

abstract：:Eighty-seven murine monoclonal antibodies (MAb) produced against human tumors of various origins and representing six different immunoglobulin classes were tested for antitumor reactivity in antibody-dependent cell-mediated cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC) assays. Mouse splenocytes, thio...

journal_title：Cellular immunology

authors： Herlyn D,Herlyn M,Steplewski Z,Koprowski H

更新日期：1985-04-15 00:00:00

abstract：:We have examined noninduced cytotoxicity of mouse gut associated and peripheral lymphoid tissues for a wide variety of syngeneic as well as allogeneic cell lines and lymphoblasts. Lymphoid cells from Peyer's patches were found to lyse these targets in a 3-hr chromium release assay whereas lymphoid cells from intestina...

journal_title：Cellular immunology

authors： Gautam SC,Beckman K,Battisto JR

更新日期：1986-09-01 00:00:00